211272 Protective effects of sodium ferulate in vascular endothelial function during cardiopulmonary bypass

/Liao Jianyi(廖健毅，Soochow Univ Affil Childen’s Hosp，Suzhou 215003)…∥Chin J Thorac Cardiovasc Surg.-2011，27(4).-221～223

ObjectiveCardiopulmonary bypass(CPB)and its related ischemia reperfusion injury may cause endothelial cell injury.To study the protective effects of sodium ferulate in vascular endothelial function during CPB by testing the changes of vascular endothelial cell(CEC)，nitric oxide(NO)and endothelin-1(ET-1)in children with congenital heart disease.MethodsSixty patients with congenital heart disease，including 28 males and 32 females were studied.The mean age was(19.7 ± 10.4)months and body weight(10.5 ±6.1)kg.There were 37 VSD，8 ASD，7 TOF，5 TAPVC and 3 CAVC，among them 26 patients had pulmonary hypertension.They were randomly divided into two groups:sodium ferulate group(group S，n=30)，and control group(group C，n=30).Sodium ferulate(8 mg/kg)was given intravenously before CPB.Blood samples were taken from the arterial line at following time points:before CPB(TO)，bypass 30 min(Tl)，the termination of CPB(T2)，2h after operation(T3)and 6h after operation(T4)，respectively for determination the concentration of vascular endothelial cell(CEC)in the blood，the concentration of nitric oxide(NO)and endothelin-1(ET-1)in the plasma.ResultsThere were no significant difference for the two groups regarding above parameters at TO(P ＞0.05).The level of CEC was significantly elevated after CPB in both groups(P ＜0.05).CEC were lower at T2in group S than in group C(P ＜0.05).NO was decreased in both groups，but was higher in group S at T2，T3 and T4(P ＜0.05).The concentration of plasma ET-1 was not significantly different before CPB，but there was a slight decrease at T1，and then it was significantly increased in both groups(P ＜0.05).But it was lower in group S than in group C at T1，T2，T3 and T4(P ＜0.05 orP ＜ 0.01).ConclusionThere was severe endothelial cell damage during CPB.Sodium Ferulate can effectively antagonize the secretion of ET-1 to promote the formation of NO.Therefore，it reduces CPB-induced endothelial cell damage and protects vascular endothelial function during CPB.20 refs，1 tab.