212010 Expression and significance of caveolin-1 in breast carcinoma

/Gao Xue(高雪，Dept Pathol，1 st Affil Hosp Dalian Med Univ，Dalian 116011)…∥Chin J Gen Surg.-2011，26(11).-928 ～931

ObjectiveTo investigate the expression and significance of caveolin-1 in breast carcinoma.MethodsU-sing immunohistochemical method the protein expression of caveolin-1 were analyzed in 105 cases of breast carcinoma and 50 cases of non-cancerous breast tissues.The relationship between caveolin-1 expression and CK5/6，EGFR，and E-cadherin expression was investigated.Clinical data of 105 cases of breast carcinoma were retrospectively analyzed.ResultsAmong 105 cases of breast carcinoma，there were 20 cases of basal-like subtype，22 cases of luminal subtype A，23 cases of luminal subtype B，23 cases of HER2 over-expressing subtype，17 cases of normal breast-like subtype.Positive rate of caveolin-1 was significantly lower in breast carcinoma than in noncancerous breast tissues(24.8%vs.88.0%，P ＜0.05).Positive rate of caveolin-1(75.0%)was higher in breast carcinoma than in luminal subtype A(4.8%)，luminal subtype B(17.4%)，HER2 over-expressing subtype(17.4%)or normal breast-like subtype(11.8%)，all P＜ 0.05.Caveolin-1 expression was associated with expression of CK5/6 and EGFR(P ＜0.01).In univariate analysis，positive caveolin-1 was associated with higher lymph node metastasis rate(18/26，69.2%)than negative(37/79，46.8%)，P=0.047，and shorter 5-year-disease-free survival(38.46%vs.74.68%，P=0.0004)，but in multivariate analysis caveolin-1 was not an independent predictor of 5-year-disease-free survival(P ＞0.05).ConclusionCaveolin-1 can be seen as a screening mark of basal-like breast carcinoma，it may promote the invasiveness of breast cancer cells，but it is not an independent prognostic predictor of breast cancer patients.9 refs，6 figs，3 tabs.