

[摘要] 目的 分析美托洛爾聯合曲美他嗪治療冠心病心力衰竭臨床療效。方法 整群選取從2015年1月—2016年1月該院收治的156例冠心病心力衰竭患者,隨機分為對照組(80)與治療組(76),對照組采取常規藥物治療,治療組在對照組基礎上采用美托洛爾聯合曲美他嗪治療,對比兩組療效。結果 治療后,治療組LVEF(51.56±2.74)、LVESD(30.75±3.64)、LVEDD(51.27±4.28)、SBP(120.08±6.32)、DBP(80.74±5.35)、HR(77.65±7.12)指標改善優于對照組LVEF(44.08±3.57)、LVESD(37.08±3.52)、LVEDD(58.23±5.31)、SBP(131.34±8.45)、DBP(88.17±6.48)、HR(86.34±6.24)(P<0.05)。對照組總有效率為75.00%,治療組為92.11%,治療組明顯高于對照組(P<0.05)。對照組不良反應發生率為12.50%,治療組為10.52%,兩組差異無統計學意義(P>0.05)。 結論 對冠心病心力衰竭采用美托洛爾聯合曲美他嗪治療,安全有效,具有臨床應用價值。
[關鍵詞] 冠心病;心力衰竭;美托洛爾;曲美他嗪;療效
[中圖分類號] R5 [文獻標識碼] A [文章編號] 1674-0742(2016)10(b)-0118-03
[Abstract] Objective To analyze the metoprolol combined with trimetazidine of trimetazidine in patients with coronary heart disease and heart failure clinical curative effect. Methods Group selection a total of from January 2015 — January 2016 156 cases of coronary heart disease patients with heart failure, were randomly assigned to control group (n = 80) and treatment group (76), the control group take routine treatment, treatment group in the control group based on the use of metoprolol combined with trimetazidine treatment, the curative effects were compared between two groups. Results After treatment, treatment group LVEF(51.56±2.74)、LVESD(30.75±3.64)、LVEDD(51.27±4.28)、SBP(120.08±6.32)、DBP(80.74±5.35)、HR(77.65±7.12)indicators better than control group LVEF(44.08±3.57)、LVESD(37.08±3.52)、LVEDD(58.23±5.31)、SBP(131.34±8.45)、DBP(88.17±6.48)、HR(86.34±6.24)(P<0.05). In control group, the total effective rate was 75.00%. The treatment group was 92.11%, the treatment group was significantly higher than that of control group(P<0.05). In the control group, the incidence rate of adverse reaction was 12.50%, the treatment group was 10.52%, two groups no significant difference(P>0.05). Conclusion On coronary heart disease and heart failure with metoprolol combined with trimetazidine treatment, safe and effective, has the value of clinical application.
[Key words] Coronary heart disease; Heart failure; Metoprolol M; Sibutramine trimetazidine; Curative effect
臨床中,冠心病屬于慢性心血管疾病,老年群體較為多發,冠心病終末期易出現心力衰竭。最近幾年以來,隨著冠心病心力衰竭發病率提高,對于該疾病防治有著重要作用。通常情況下,多采用血管緊張素轉換酶抑制劑、強心劑、利尿劑等多種藥物聯合治療,治療冠心病心力衰竭藥物較多,但療效并不理想[1-3]。該文主要分析美托洛爾聯合曲美他嗪治療該院從2015年1月—2016年1月收治的156例冠心病心力衰竭患者臨床療效,效果顯著,現報道如下。
1 資料與方法
1.1 一般資料
整群選取從2015年1月—2016年1月收治的156例冠心病心力衰竭患者,隨機分為對照組(80)與治療組(76)。均符合2007年《中國慢性心力衰竭診斷治療指南》[4]相關診斷標準,通過影像學診斷確診。將對美托洛爾、曲美他嗪藥物過敏、心肝功能不全患者排除。……