腹腔鏡手術聯合促性腺激素釋放激素激動劑治療卵巢內異囊腫的臨床研究

[摘要] 目的 探討腹腔鏡手術聯合促性腺激素釋放激素激動劑治療卵巢內異囊腫的臨床效果。方法 隨機選擇自2014年1—12月期間，該院收治的60例卵巢內異囊腫的患者為研究對象。采用隨機數表法將患者分2組，觀察組（n=30）和對照組（n=30）。兩組患者均接受常規腹腔鏡手術治療，觀察組患者在術后加用促性腺激素釋放激素激動劑治療。患者的B超和臨床癥狀作為療效觀察指標。結果 觀察組患者的治療有效率為86.67%，對照組患者治療有效率為63.33%，兩組間差異有統計學意義（P < 0.05）。觀察組的血清相關性激素水平改善顯著優于對照組（P < 0.05）。術后隨訪一年，觀察組出現1例復發；對照組出現3例復發，組間差異有統計學意義（P < 0.05）。觀察組不孕要求生育者15例，其中5例受孕；對照組不孕要求生育者16例，其中1例受孕，組間差異有統計學意義（P < 0.05）。結論 腹腔鏡手術聯合促性腺激素釋放激素激動劑治療卵巢內異囊腫的臨床效果好，復發率低，受孕率高，值得推廣應用。

[關鍵詞] 腹腔鏡手術；促性腺激素；釋放激素激動劑；卵巢內異囊腫；臨床研究

[中圖分類號] R713.6 [文獻標識碼] A [文章編號] 1674-0742（2016）10（b）-0072-03

[Abstract] Objective To investigate the clinical effect of laparoscopic surgery combined with gonadotropin releasing hormone agonist in the treatment of ovarian endometriosis cyst. Methods Random selection from January 2014 to December 2014， 60 cases of ovarian endometriosis cyst in our hospital patients as the research object. Using a random number table method were divided into 2 groups， observation group （n = 30） and the control group （n = 30）. Two groups were treated with conventional laparoscopic surgery， patients in the observation group were added with gonadotropin-releasing hormone agonist treatment. Clinical symptoms and type-B ultrasonic were therapeutic effect index. Results The effective rate of the observation group was 86.67%， control group patients effective rate was 63.33%， there were significant differences between the two groups （P < 0.05）. The correlation between the serum hormone level in the observation group improved significantly better than the control group （P < 0.05）. One year follow-up， 1 cases of recurrence in observation group； the control group had 3 cases of recurrence， there were significant differences between the groups （P < 0.05）. Observation group infertility fertility requirements in 15 cases， including 5 cases of pregnancy； control group infertility fertility requirements in 16 cases， which 1 cases of pregnancy， between groups exist significant difference （P < 0.05）. Conclusion Laparoscopic surgery combined with promoting gonadal hormone releasing hormone excited agent in the treatment of ovarian endometriosis cyst of good clinical effect， low recurrence rate， pregnancy rate is high， it is worth popularization and application.

[Key words] Laparoscopic surgery； Gonadotropin releasing hormone； Agonist； Ovarian endometriosis cyst； Clinical research

卵巢子宮內膜異位囊腫是婦科常見病，好發于育齡婦女，發病率為1%～7%，可以導致婦女不孕不育[1]。近年，腹腔鏡微創手術的發展，逐漸代替了傳統的開腹手術，但是手術治療卵巢內異囊腫仍容易復發[2]。研究指出，術后繼續采用激素類藥物輔助治療可以減少該病的復發率，臨床常用的有孕激素、孕激素受體拮抗劑和促性腺激素釋放激素激動劑（GnRH-α）等。……