復方丹參注射液和50%硫酸鎂溶液濕敷在新生兒輸液外滲中的效果對比

袁玉環+劉二瑛+麥惠瓊

[摘要]目的 觀察比較復方丹參注射液和50%硫酸鎂溶液濕敷治療新生兒輸液外滲的臨床效果。方法 選取2015年3月～2016年3月于我院行靜脈輸液的新生兒共131例，均有輸液外滲癥狀，隨機分為對照組65例和觀察組66例，對照組濕敷50%硫酸鎂溶液治療，觀察組濕敷復方丹參注射液治療，對比兩組消腫時間、顯效時間、治療效果及不良反應。結果 觀察組的開始消腫、完全消腫、顯效時間分別為（2.78±0.57）、（9.12±1.13）、（5.73±0.63）d，而對照組分別為（5.61±1.49）、（16.32±1.43）、（10.54±1.05）d，觀察組均短于對照組，差異有統計學意義（P<0.01）；觀察組患者治療總有效率為98.48%，與對照組的73.85%比較，差異有統計學意義（P<0.01）；觀察組患者不良反應發生率為0，與對照組的12.3%比較，差異有統計學意義（P<0.05）。結論 對臨床中出現輸液外滲的新生兒應用復方丹參注射液濕敷，起效快，效果好，安全性高，值得推廣。

[關鍵詞]輸液外滲；新生兒；復方丹參注射液；50%硫酸鎂溶液；濕敷

[中圖分類號] R556.6+3 [文獻標識碼] A [文章編號] 1674-4721（2017）03（a）-0176-04

[Abstract]Objective To observe the clinical effects of compound Danshen Injection and 50% Magnesium Sulfate Solution wet deposition in treating neonatal transfusion extravasation.Methods 131 neonatal were accepted intravenous infusion from March 2015 to March 2016 of our hospital were selected.All neonatal had the symptoms of transfusion extravasation.Neonatal were randomly divided into control group （65 cases） and observation group （66 cases）.Neonatal in control group were used 50% Magnesium Sulfate Solution wet deposition，and neonatal in observation group were used compound Danshen Injection.Swelling time，effective time，treatment effects and adverse effects in two groups were compared.Results The beginning swelling time， totally swelling time and effective time in observation group were respectively（2.78±0.57），（9.12±1.13），（5.73±0.63）h，and the control group was respectively（5.61±1.49），（16.32±1.43），（10.54±1.05）h in control group，those time of the observation group was shorter than the control group，and the differences were significant （P<0.01）.The effective time in observation group was 98.48%， which was 73.85% in control group，and the difference was significant（P<0.01）.The incidence rate of adverse effects in observation group was 0，which was 12.3% in control group，and the difference was significant（P<0.05）.Conclusion Using compound Danshen Injection wet deposition for neonatal with transfusion extravasation in clinical，which has the advantages of rapid onset，good effects and high safety，and it is worth to popularize.

[Key words]Transfusion extravasation；Neonatal；Compound Danshen Injection；50% Magnesium Sulfate Solution；Wet deposition

靜脈輸液是臨床常規的給藥方式，廣泛應用于各種人群臨床治療中。但新生兒多易哭鬧，不能按需要制動，加上其血管細、充盈度差等原因，患兒在輸液過程中易出現輸液外滲等癥狀，嚴重者甚至出現皮下組織壞死，嚴重影響新生兒的生長健康[1]。以往臨床多對患兒進行濕敷50%硫酸鎂溶液治療，但臨床效果一般。近年來，隨著醫學水平不斷提升，大量高效新型藥物被研制出來，臨床將復方丹參注射液應用于輸液外滲患兒中，取得良好的應用效果[2]。本文對我院131例輸液外滲新生兒進行研究，分別實施50%硫酸鎂溶液和復方丹參注射液進行濕敷治療，結果提示，復方丹參注射液的臨床治療效果顯著，現報道如下。