劉園園,李偉,李冠軍,王靜華,岳玲,洪波,安娜,蘇寧,肖世富
·論著·
老年女性遺忘型與血管型輕度認(rèn)知功能障礙患者的認(rèn)知功能比較
劉園園,李偉,李冠軍,王靜華,岳玲,洪波,安娜,蘇寧,肖世富
目的探討老年女性遺忘型輕度認(rèn)知功能障礙(aMCI)和血管型輕度認(rèn)知功能障礙(vMCI)患者認(rèn)知缺損的特征。方法對(duì)163例老年女性aMCI 患者和22例女性vMCI 患者采用簡(jiǎn)易精神狀態(tài)檢查量表(MMSE)、蒙特利爾認(rèn)知評(píng)估量表(MoCA)和老年成套神經(jīng)心理測(cè)驗(yàn)(NTB)評(píng)估其認(rèn)知功能,并進(jìn)行比較。結(jié)果aMCI組和vMCI組在寫(xiě)句子、畫(huà)圖、命名、注意力、視覺(jué)辨認(rèn)-功能聯(lián)系、視覺(jué)辨認(rèn)-語(yǔ)義聯(lián)系、語(yǔ)言流暢性、韋氏填圖的測(cè)驗(yàn)上差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論通過(guò)NTB的語(yǔ)義記憶測(cè)試和執(zhí)行功能測(cè)驗(yàn)可以較好的區(qū)分vMCI 和aMCI,但該結(jié)論僅限于老年女性。
血管型輕度認(rèn)知功能障礙; 遺忘型輕度認(rèn)知功能障礙; 簡(jiǎn)易精神狀態(tài)檢查量表; 蒙特利爾認(rèn)知評(píng)估量表; 老年成套神經(jīng)心理測(cè)驗(yàn)
Abstract:Objective: to analyze and compare the cognitive impairment characteristics between amnestic mild cognitive impairment (aMCI) patients and vascular mild cognitive impairment (vMCI) patients.Method:163 female aMCI patients and 22 female patients with vMCI were selected as our study subjects,using the mini mental state examination (MMSE),Montreal cognitive assessment scale (MoCA) and neuropsychological test baterry(NTB) to assess their cognitive function.Results:There were statistically significant differences in written sentences,drawing,naming,attention,visual function,visual recognition semantic connection,language fluency,Wechsler picture completion test (P<0.05) between female aMCI and female vMCI patients.Conclusion:vMCI and aMCI can be distinguished by the semantic memory test and performance test of NTB,but the conclusion is limited to women.
Keywords: vascular mild cognitive impairment; amnestic mild cognitive impairment; mini mental state examination; Montreal cognitive assessment scale; neuropsychological test baterry
輕度認(rèn)知功能障礙(MCI)是介于正常老齡化和癡呆之間的一種中間狀態(tài),通常可被認(rèn)為是癡呆的前驅(qū)期[1]。不同類(lèi)型MCI具有不同的病理特征,其轉(zhuǎn)歸也不一致[2]。目前對(duì)遺忘型MCI(aMCI)已做了較多的研究,而血管型MCI(vMCI)的研究則一直處于相對(duì)的弱勢(shì)[3-4]。前期的研究[1]發(fā)現(xiàn),vMCI患者的注意力、執(zhí)行功能、運(yùn)動(dòng)能力及信息處理能力比aMCI患者下降的更明顯,但該研究并未排除性別對(duì)結(jié)果的影響。因此,本研究著重探討女性vMCI 患者與女性aMCI患者在神經(jīng)心理測(cè)驗(yàn)上的差異。
在1 068例社區(qū)老人中,以163例女性aMCI和22例女性vMCI 患者作為研究對(duì)象,診斷符合Petersen 標(biāo)準(zhǔn),即aMCI診斷標(biāo)準(zhǔn): ①總體認(rèn)知功能正常;……