同步放化療與序貫放化療治療局部晚期非小細胞肺癌的效果比較

趙強德　汪嬌龍　李春燕

[摘要]目的 探討同步放化療與序貫放化療治療局部晚期非小細胞肺癌（NSCLC）的效果。方法 選取2016年1月～2018年1月我院收治的52例局部晚期NSCLC患者作為研究對象，按照序列分組方法分為對照組（26例）和觀察組（26例）。對照組采取序貫放化療治療，觀察組采取同步放化療治療，比較兩組的臨床療效及生存質量評分。結果 觀察組治療總有效率為73.07%，高于對照組38.46%，差異有統計學意義（P<0.05）。兩組治療前生存質量評分中的角色、軀體、認知、情緒及社會功能和總健康狀況評分比較，差異無統計學意義（P>0.05），觀察組治療后軀體、總健康狀況評分高于對照組，差異有統計學意義（P<0.05）。結論 將同步放化療在局部晚期NSCLC患者的治療，可顯著促進臨床治療效果和患者生存質量的提升，臨床應用予以推薦。

[關鍵詞]局部晚期非小細胞肺癌;序貫放化療;同步放化療

[中圖分類號] R734.2 ? ? [文獻標識碼] A ? ? [文章編號] 1674-4721（2019）9（b）-0057-03

Effect comparison of the concurrent radiotherapy and sequential radiotherapy and chemotherapy in the treatment of locally advanced non-small cell lung cancer

ZHAO Qiang-de? ?WANG Jiao-long? ?LI Chun-yan

Department of Oncology， Yingtan People′s Hospital， Jiangxi Province， Yingtan? ?335000， China

[Abstract] Objective To investigate the effect of concurrent radiotherapy and sequential radiotherapy and chemotherapy in the treatment of locally advanced non-small cell lung cancer （NSCLC）. Methods A total of 52 patients with locally advanced NSCLC admitted to our hospital from January 2016 to January 2018 were selected as the study subjects. They were divided into control group （26 cases） and observation group （26 cases） according to the sequence. The control group was treated with sequential radiotherapy and chemotherapy， while the observation group was treated with concurrent radiotherapy and chemotherapy. The clinical efficacy and quality of life score of the two groups were compared. Results The total effective rate of treatment in the observation group was 73.07%， higher than that in the control group （38.46%）， with statistical difference （P<0.05）. There was no statistical difference in the role， body， cognition， emotion， social function and total health status between the two groups before treatment （P>0.05）. After treatment， the indexes of body and total health status in the observation group were higher than those in the control group， with statistical difference （P<0.05）. Conclusion Concurrent chemoradiotherapy in the treatment of locally advanced NSCLC patients can significantly improve the clinical efficacy and quality of life of patients， therefore， clinical application is recommended.

[Key words] Locally advanced non-small cell lung cancer; Sequential radiotherapy and chemotherapy; Concurrent radiotherapy and chemotherapy

現階段，受人口老齡化加劇和工業化進程加速的影響，肺癌患者也呈現出增長之勢[1]。相比較健壯的青年人而言，老年人的身體免疫機能減弱，同時還合并其他多種基礎代謝性疾病，成為肺癌的易感人群。而在肺癌患者中，約有7成以上為局部晚期非小細胞肺癌（NSCLC）[2]。局部晚期NSCLC患者在發現時多錯過了最佳的手術治療時機，臨床多采取放化療進行治療。采取放化療對局部晚期NSCLC患者治療，可以減輕患者痛苦，提高整體療效。為探討同步放化療和序貫放化療在局部晚期NSCLC患者治療中的治療價值，本研究特調查我院接受治療的52例局部晚期NSCLC患者，現報道如下。