注射用炎琥寧聯合磷酸奧司他韋顆粒治療小兒病毒性肺炎的效果

林萬鴻 曾憲輝 伍清龍

摘要：目的 ?探討注射用炎琥寧聯合磷酸奧司他韋顆粒治療小兒病毒性肺炎的臨床效果。方法 ?選取2018年1月～2019年10月本院兒科收治的68例病毒性肺炎患兒為研究對象，按照隨機數字表法分成對照組與觀察組，各34例。對照組給予磷酸奧司他韋顆粒治療，觀察組給予注射用炎琥寧聯合磷酸奧司他韋顆粒治療，比較兩組臨床癥狀消失時間、治療前后炎性標志物[腫瘤壞死因子TNF-α、C反應蛋白（CRP）及白細胞介素6（IL-6）水平]、總有效率及藥物不良反應發生情況。結果 ?觀察組的臨床癥狀（熱退、咳嗽與啰音）消失時間短于對照組（P<0.05）;治療后觀察組炎性標志物均低于對照組（P<0.05）;觀察組總有效率（94.12%）高于對照組（79.41%）（P<0.05）。兩組藥物不良反應發生率比較，差異無統計學意義（P>0.05）。結論 ?注射用炎琥寧聯合磷酸奧司他韋顆粒治療小兒病毒性肺炎有助于緩解臨床癥狀，降低血清炎性指標，提高療效，安全性高，無嚴重藥物不良反應，值得聯合應用。

關鍵詞：炎琥寧;磷酸奧司他韋;小兒病毒性肺炎

中圖分類號：R725.6 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 文獻標識碼：A ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? DOI：10.3969/j.issn.1006-1959.2020.17.043

文章編號：1006-1959（2020）17-0148-03

Abstract：Objective ?To explore the clinical effect of Yanhuning for injection combined with oseltamivir phosphate particles in the treatment of children with viral pneumonia.Methods ?A total of 68 children with viral pneumonia admitted to the Department of Pediatrics of our hospital from January 2018 to October 2019 were selected as the research objects， and were divided into a control group and an observation group according to the random number table method， with 34 cases in each group. The control group was treated with oseltamivir phosphate granules， and the observation group was treated with Yanhuning for injection combined with oseltamivir phosphate granules. The disappearance time of clinical symptoms and the inflammatory markers before and after treatment were compared between the two groups [tumor necrosis factor TNF-α， C-reactive protein （CRP） and interleukin 6 （IL-6） levels]， total effective rate and occurrence of adverse drug reactions.Results ?The disappearance time of clinical symptoms （feeling， cough and rales） in the observation group was shorter than that in the control group（P<0.05）; after treatment， the inflammatory markers in the observation group were lower than those in the control group（P<0.05）; the total effective rate （94.12%） of the observation group was higher than that of the control group （79.41%）（P<0.05）. There was no significant difference in the incidence of adverse drug reactions between the two groups （P>0.05）.Conclusion ?Yanhuning for injection combined with oseltamivir phosphate particles in the treatment of children with viral pneumonia could help relieve clinical symptoms， reduced serum inflammatory indicators， improved efficacy， high safety， and no serious adverse drug reactions. It is worthy of combined application.

Key words：Yanhuning;Oseltamivir phosphate;Viral pneumonia in children

小兒病毒性肺炎（viral pneumonia in children）由上呼吸道病毒感染向下蔓延所致的肺部炎癥，為一種常見的吸入性急性呼吸道疾病，若治療不及時，輕者肺間質、肺泡炎癥浸潤加重，重者可致急性呼吸窘迫綜合征、肺功能不全甚至肺衰竭，嚴重危害小兒身心健康[1]。祖國醫學將其歸屬為“肺炎喘嗽”范疇，多由風熱肺閉引起，治以宣肺開閉、疏風解毒為主，臨床常用藥有炎琥寧、熱毒寧、磷酸奧司他韋等，本研究應用注射用炎琥寧聯合磷酸奧司他韋顆粒治療小兒病毒性肺炎取得一定療效，現報道如下。……