Postoperative pain due to an occult spinal infection: A case report

Michiel Frederik Vande Kerckhove,Vincent Fiere,Thais Dutra Vieira,Sami Bahroun,Marc Szadkowski,Henri d'Astorg

Michiel Frederik Vande Kerckhove,Vincent Fiere,Thais Dutra Vieira,Sami Bahroun,Marc Szadkowski,Henri d'Astorg,Centre Orthopédique Santy,Hopital Privé Jean Mermoz,Ramsay-G énérale de Santé,Lyon,France

Abstract BACKGROUND A high degree of vigilance is warranted for a spinal infection,particularly in a patient who has undergone an invasive procedure such as a spinal injection. The average delay in diagnosing a spinal infection is 2-4 mo. In our patient,the diagnosis of a spinal infection was delayed by 1.5 mo.CASE SUMMARY A 60-year-old male patient with a 1-year history of right-sided lumbar radicular pain failed conservative treatment. Six weeks to prior to surgery he received a spinal injection,which was followed by increasing lumbar radicular pain,weight loss and chills. This went unnoticed and surgery took place with right-sided L4-L5 combined microdiscectomy and foraminotomy via a posterior approach. The day after surgery,the patient developed left-sided lumbar radicular pain. Blood cultures grew Staphylococcus aureus (S. aureus). Magnetic resonance imaging showed inflammatory aberrations,revealing septic arthritis of the left-sided L4/L5 facet joint as the probable cause. Revision surgery took place and S. aureus was isolated from bacteriological samples. The patient received postoperative antibiotic treatment,which completely eradicated the infection.CONCLUSION The development of postoperative lower back pain and/or lumbar radicular pain can be a sign of a spinal infection. A thorough clinical and laboratory work-up is essential in the preoperative evaluation of patients with spinal pain.

Key Words: Arthritis; Septic; Lumbar region; Disc herniated; Spinal injections; Case report

INTRODUCTION

Lumbar disc herniation (LDH) is a common cause of lower back pain and lumbar radicular pain. Conservative treatment consisting of analgesic drugs,anti-inflammatory drugs and adapted movement is generally favourable in the general population,with complete recovery in 70%-80% of cases[1]. Spinal injections are commonly used as an additional treatment. One of the potential risks of spinal injection is infection. A review by Windsoret al[2] reported the occurrence of infections after 1%-2% and severe infections after 0.01%-0.1% of all spinal injections.Staphylococcus aureus(S. aureus) is the most common organism isolated and is thought to be introduced through the skin by needle puncture[3].

We report the case of a patient with right-sided L4-L5 LDH. During conservative treatment he underwent right-sided transforaminal injection. This did not lead to an improvement in his symptoms and a decision was made to carry out surgery. In the immediate postoperative period,he progressed favourably with temporary relief of pain,but on day 1 postoperatively he developed excruciating left-sided lumbar radicular pain. Investigations and retrospective analyses demonstrated left-sided septic L4-L5 facet joint arthritis caused byS. aureus,most probably as a result of the spinal injections 6 wk prior to surgery. The infection was successfully treated with revision surgery and antibiotic therapy.

Statement of informed consent

The patient was informed that data concerning the case would be submitted for publication and gave his consent. The study received institutional review board approval (COS-RGDS-2020-04-002-DASTORG-H).

CASE PRESENTATION

Chief complaints

A 60-year-old male patient was admitted to hospital for treatment of right-sided lumbar radicular pain.

History of present illness

Clinically,there was irradiating right leg pain in the L4 dermatome. The patient had a 1-year history of this symptom.

History of past illness

He did not have a past history of low back pain or LDH.

Personal and family history

The patient had no clinically relevant comorbidities,except for being overweight(body mass index of 27). The patient had no prior relevant medical history. He was a non-smoker,had no allergies and was not diabetic. The patient didn’t have any family history related to low back pain or LDH.

Physical examination

Physical examination demonstrated a motor deficit of his right quadriceps,with 4/5 strength.

Laboratory examinations

Preoperative laboratory tests showed a white blood cell (WBC) count of 11 000/μl,normal creatinine and normal haemostatic parameters. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were not measured preoperatively as this is not done routinely in our department for non-instrumented spinal surgery.

Imaging examinations

A magnetic resonance imaging (MRI) scan performed 2 d before the last infiltration,1.5 mo prior to surgery,showed right-sided L4-L5 foraminal LDH,with compression of the right L4 nerve root. Intra-articular fluid collection was seen in the facet joints of L4-L5,without the presence of other inflammatory findings in the L4-L5 area(Figure 1).

He underwent extensive but unsuccessful conservative treatment with oral analgesics (paracetamol 1 g (1-1-1-1) and ibuprofen 600 mg (1-1-1)),rest and two rightsided L4-L5 transforaminal injections over a period of 1 year,with no clinical improvement. Over the last 3 mo,his level of pain had increased significantly,with a combination of irradiating right-sided leg pain and lower back pain.

Six weeks prior to surgery,our patient received a second right-sided transforaminal injection with cortisone. In the period following this injection,his pain level increased further,with a combination of irradiating right-sided leg pain and lower back pain.His treating physician subsequently increased his oral pain medication to level 3 analgesia with oxycodon 10 mg (1-1-1),but this failed to provide pain relief. In addition,cortisone-therapy with intramuscular solumedrol was instituted without success. This led to the consultation for surgery.

Bilateral microdecompression and right-sided L4-L5 combined microdiscectomy and foraminotomy by the posterior approach were carried out successfully.Preoperative antibiotic prophylaxis consisted of 2 g intravenous (IV) cefazolin. There were no clear intra-operative findings suggestive of infection. In the immediate postoperative period,the patient had complete relief from right-sided irradiating leg pain and was very satisfied. On the first day after the operation,he developed an excruciating irradiating pain in his left leg,which was contralateral to the side of the original herniation. The pain persisted and an MRI scan was carried out on day 4 postoperatively. This was almost normal,with bilateral decompression of L4-L5 and a small fluid collection in the left-sided facet joint of L4-L5 (Figure 2). No recurrent LDH,haematoma,or middle- to high-grade compressive pathology that could explain the new pattern of irradiating pain in the left leg was noted.

The patient remained in hospital for further observation. On day 5 post-surgery he developed a fever of 39 °C and chills. The clinical appearance of his wound was normal. As a standard measure in our hospital,with fever ＞ 38.5 °C,blood cultures were taken and these grewS. aureus. With the high-level of suspicion of an infection,a second MRI scan was carried out on day 6 postoperatively,showing an increase in fluid collection in the posterior spine and the presence of air collections and inflammatory changes around the left-sided facet joint of L4-L5 (Figure 3).

FINAL DIAGNOSIS

Septic arthritis of the left-sided L4/L5 facet joint,withS. aureus.

TREATMENT

Revision surgery was performed 6 d after the first operation,with evacuation of the fluid collection. Bacteriological samples were taken,drainage,debridement and lavage were performed. Antibiotic therapy was instituted,initially empirically with IV vancomycin 1 g (1-0-1) and IV cloxacillin 3 g (1-1-1-1) for 5 d. In view of the antibiogram (Table 1),his antibiotic therapy was switched to IV cefazolin (2 g; 1-1-1)for 23 d,at home,through a central catheter inserted peripherally. After this time,his antibiotic therapy was switched to oral ofloxacin (400 mg; 1-0-0) and rifampicin (600 mg; 1-0-0) for 2 wk.

Table 1 Antibiogram: Sensitivity tests of the intra-operatively isolated Staphylococcus aureus to different antibiotics

Figure 1 Magnetic resonance imaging scan done 2 d before the last infiltration,1.5 mo preoperatively. A: T2-weighted axial magnetic resonance imaging (MRI) image; B: T2-weighted right-sided sagittal MRI image showing right-sided foraminal lumbar disc herniation at L4-L5 (orange arrows),with compression of the right-sided exiting L4-nerve root; C: T2-weighted left-sided sagittal MRI image showing a slight bulging of the L4-L5 disc,without compression of the exiting nerve root. In (A) and (C) fluid collections can be seen in both facet joints (yellow arrows),without visible signs of edema.

OUTCOME AND FOLLOW-UP

His inflammatory parameters returned to normal over a period of 3 wk. Three months after surgery,he was not taking any pain medication and had no leg pain,although there was a persisting motor deficit of the right quadriceps,with 4/5 strength,and he was easily fatigued. Through a rehabilitation program his physical condition improved significantly,so that at his 9-mo follow-up appointment he was already playing sport again,with a lot of walking and swimming.

Figure 2 Magnetic resonance imaging scan on day 4 postoperatively. A: T2-weighted axial magnetic resonance imaging (MRI) image showing a central decompression on L4-L5,with removal of the right-sided foraminal herniation. A fluid collection can be seen in both L4-L5 facet joints (yellow arrows); B and C: Rightsided and left-sided T2-weighted sagittal MRI images showing removal of the right-sided foraminal disc herniation; D: T2-weighted central sagittal MRI image showing a fluid collection (blue arrow),with small air collections (orange arrow) and a drain (purple arrow).

Figure 3 Magnetic resonance imaging scan on day 6 postoperatively. A: Axial T1-TSE-FS-weighted magnetic resonance imaging (MRI) image at the level of L4-L5 showing a fluid collection in both facet joints; B and C: Right-sided and left-sided T1-TSE-weighted sagittal MRI image showing an increase in fluid collections,especially left-sided (blue arrows),and an increase in edema in the bone,facet joint and muscles surrounding the facet joints (light blue arrows); D: T1-TSE-weighted central sagittal MRI image showing an increase in fluid collection (blue arrow),with an increase in air collections (orange arrow).

A detailed medical history was taken after his revision surgery and he stated that,during the 6 wk prior to surgery,he had lost 12 kg in weight,which he had attributed to the pain,and chills,which he had attributed to the use of opioids and which he had not reported to the medical staff. These cardinal symptoms of an infection,weight loss and chills,started 4 d after the last right-sided transforaminal L4-L5 injection.

DISCUSSION

In our patient,the diagnosis of a spinal infection was delayed by 6 wk. It should be noted that the average delay in diagnosing a spinal infection is 2-4 mo[4]. This shows that a high level of vigilance for a spinal infection is warranted,especially in patients who are more susceptible to developing an infection,such as those who are immunocompromised,diabetic,dialysis-dependent,have permanent vascular access,or are IV drug abusers[5]. A high degree of vigilance is also necessary in patients undergoing invasive procedures such as spinal injections[2]. In this case,we presume that the first surgery resulted in a stress response,as proposed by Bardramet al[6],which might have decreased the immune response to the infection and,as such,might have led to an increase in the extent of the infection.

Monitoring for a possible spinal infection can be achieved by focusing on history taking,clinical examination and laboratory results. Typical signs of an infection are fever,night sweats,chills,night pain,pain resistant to analgesics and weight loss. In this case,these symptoms were not mentioned by the patient and were not discovered by the clinicians prior to surgery. Routine questioning about these symptoms could improve the sensitivity of detection of an underlying infection.

A literature review by Yoonet al[7] showed that approximately 50% of cases of septic arthritis of the facet joint have leukocytosis and all previous case reports (n= 61)except for one,had an elevated ESR and/or CRP. In our patient,ESR and CRP were not measured in the preoperative work-up as this is not done routinely in our hospital for non-instrumented spinal surgery. Our patient’s WBC count was at the upper limit of normal at 11000/μL. Routine measurement of ESR and CRP levels could improve the sensitivity of detection of an underlying infection. Moreover,patients with fever and back pain following an invasive procedure should have blood cultures performed routinely,as these are positive in around 60% of cases of bacterial spondylodiscitis[8].In our hospital,sequential blood cultures are performed as a standard procedure in patients with fever ＞ 38.5 °C,and in the present case,they were positive forS. aureus.In the first few day’s post-surgery,body temperature rises frequently as a result of the inflammatory reaction to surgical trauma,but in most of these cases blood cultures remain negative. In our patient,a positive blood culture was a milestone since his MRI scan showed no conclusive results.

There is no gold-standard treatment for septic arthritis of the facet joint and treatment is based on a retrospective evaluation of case series[9]. The majority of cases are treated conservatively with IV and oral antibiotics. The literature provides no clear guidance regarding the duration and route of administration of antibiotic therapy[10].Generally,antibiotics are given for a period of 6-8 wk[11-14]. Sometimes this treatment has to be accompanied by bed rest and an orthosis for pain management[15]. Surgery is not usually indicated and is reserved for patients with an infection that is refractory to antibiotics,or with the presence of neurological deficits[12,16]. In the present case,due to the pattern of excruciating left-sided lumbar radicular pain,surgery was performed and led to a quick and significant improvement in his pain levels. He was then treated with IV and oral antibiotics for a period of approximately 6 wk. We do not have a clear explanation as to why the signs and symptoms of infection developed on the contralateral side to the surgery. We presume that this could be due to direct spread from the infiltration to the contralateral side,or due to an infiltration of the wrong-side.

The limitations of a case report design are well recognized,especially regarding external validity. However,given the rarity of this condition,the level of evidence for the optimal diagnosis of spine septic arthritis is not well-established,therefore we consider this case report important.

CONCLUSION

The development of post-operative lower back pain and/or lumbar radicular pain can be a signal of a spinal infection. A thorough clinical and laboratory work-up (CRP,ESR,leukocyte count) is essential for the preoperative evaluation of spinal patients,to identify any underlying infection.