地塞米松聯合鹽酸奧洛他定治療過敏性結膜炎的臨床效果

DOI：10.16662/j.cnki.1674-0742.2016.32.011

[摘要] 目的 比較單用氯雷他定或在此基礎上加用塞米松聯合鹽酸奧洛他定治療過敏性結膜炎的臨床效果。方法 方便選取2013年2月—2015年2月于該院接受治療的過敏性結膜炎患者140例按照隨機原則分為兩組，常規組與試驗組，各70例。常規組患者僅給予氯雷他定治療，試驗組患者氯雷他定基礎上加用地塞米松聯合鹽酸奧洛他定進行治療，觀察和記錄兩組患者的臨床療效并進行對比分析。結果 常規組患者治愈15例，顯效18例，有效16例，無效21例，治療總有效率為70.00%；而試驗組患者治愈30例，顯效20例，有效17例，無效3例，治療總有效率為95.72%。試驗組患者的治療效果較之基礎組患者存在明顯優勢，兩者差異有統計學意義（P<0.05）。結論 對過敏性結膜炎患者氯雷他定基礎上加用地塞米松聯合鹽酸奧洛他較定僅給予氯雷他定的常規治療，臨床效果顯著，值得廣泛運用。

[關鍵詞] 地塞米松；鹽酸奧洛他定； 氯雷他定； 過敏性結膜炎；病例對照研究

[中圖分類號] R5 [文獻標識碼] A [文章編號] 1674-0742（2016）11（b）-0011-03

Compare the Effect on Allergic Conjunctivitis between Loratadine Alone and loratadine Combined with Dexamethasone Combined Added Olopatadine Hydrochloride

ZHOU Long-jun

Ophthalmology Department ，Sanming Fifth Hospital of Fujian Province， Sanming， Fujian Province， 365000 China

[Abstract] Objective Compared with loratadine or on the basis of his clinical effect for the treatment of allergic conjunctivitis with dexamethasone hydrochloride combined with aulo. Methods Convenient selection from February 2013 to February 2015 in our hospital， 140 patients with allergic conjunctivitis were randomly divided into two groups， the routine group and the experimental group， 70 cases in each group. The routine group was given loratadine， desloratadine plus experimental group patients were treated with dexamethasone and he aulo hydrochloride were observed and recorded. The clinical efficacy of the two groups were analyzed and compared. Results The conventional group 15 cases were cured， 18 cases markedly effective， 16 cases effective， 21 cases ineffective， the total effective rate was 70%； while the experimental group 30 cases were cured， 20 cases markedly effective， 17 cases effective， 3 cases ineffective， the total effective rate was 95.72%. The treatment effect of the experimental group was significantly better than that of the basic group， and the difference was statistically significant （P < 0.05）.Conclusion The loratadine-based dexamethasone combinadded olopatadine hydrochloride regimen was superior to loratadine aloneconventional in treating allergic conjunctivitis.

[Key words] Dexamethasone； Olopatadine hydrochloride； Loratadin； Allergic conjunctivitis； Ccase-control study

過敏性結膜炎是指結膜對外界致敏原所產生的一種超敏性反應，其主要是由IgE介導的I型變態反應[1]。是過敏性眼病屬于眼表疾病，其中過敏性結膜炎是中最為常見的一種類型。近年來，由于配戴隱形眼鏡、使用眼部化妝品、環境污染惡化等原因導致過敏性結膜炎發病率逐步上升，因此探討過敏性結膜炎的治療具有非常重要的臨床意義。氯雷他定是治療過敏性結膜炎的基本治療方案。氣候性（季節性）過敏性結膜炎常見于中青年群體，一旦接觸致敏原即可病發，且起病迅速，當脫離致敏原時，癥狀可得到一定緩解，而過敏癥狀是否常年存在是常年性與氣候性結膜炎的主要區別[2]。……