口服利多卡因注射液治療肺癌化療后頑固性呃逆的臨床研究

DOI：10.16662/j.cnki.1674-0742.2016.32.147

[摘要] 目的 探討對肺癌化療后頑固性呃逆患者采用口服利多卡因注射液治療的臨床療效。方法 方便選取2015年7月—2016年7月該院收治的80例肺癌化療后頑固性呃逆患者進行觀察，采用隨機數字表法將患者分為研究組和對照組，每組各40例。研究組口服利多卡因注射液治療，對照組采用肌內注射利他林治療。治療10 d，觀察兩組治療效果。隨訪2周，觀察兩組患者的復發率情況。結果 研究組治療總有效率（90.00%）明顯優于對照組（80.00%）；研究組呃逆癥狀緩解時間（6.1±3.0）d、2周內復發率（5.00%）、不良反應（7.50%）明顯低于對照組的（8.2±2.9）d、15.00%、17.50%，各組數據差異有統計學意義（P<0.05）。結論 對肺癌化療后頑固性呃逆患者采用口服利多卡因注射液治療的療效安全可靠，無創給藥方式患者的耐受性好，吸收率高，值得推廣。

[關鍵詞] 利多卡因；肺癌化療；頑固性呃逆

[中圖分類號] R565.4 [文獻標識碼] A [文章編號] 1674-0742（2016）11（b）-0147-03

The Clinical Research of Oral Lidocaine Injection in the Treatment of in the Treatment of Intractable Hiccups Patients after Lung Cancer Chemotherapy

HU Meng-da

the Department of Internal Medicine in The First Affiliated Hospital of Nanyang Medical College，Nanyang，Henan Province ， 473000 China

[Abstract] Objective To discuss the clinical effects of oral lidocaine injection for Intractable Hiccups（IH） patients after Lung cancer chemotherapy. Methods Convenient selection cerebral infarction 80 patients who were collected from July 2015 to July 2016 randomly into the research group （n=40） and the control group （n=40）. There search group were recevied oral Lidocaine injection.The control group was treated with Ritalin intramuscular injection.both of the two groups were treated for 10days，observe the clinical effects of the two groups.Followed up for two weeks，observe the recurrence rate of the two group patients. Results The total effective rate in there search group（90.00%）were significantly higher than those in the control group（80.00%）；The IH symptoms alleviation time（6.1±3.0）d，the recurrence rate in two weeks（5.00%），adverse reactions（7.50%） in the research group was significantly lower than that in the control group（8.2±2.9）d、15.00%、17.50%，all the date is useful（P<0.05）. Conclusion The clinical effects of oral Lidocaine injection for IH patients after Lung cancer chemotherapy is safety and effective ，it’s easy for patients to recceive the noninvasive drug delivery method，and it has high absorption rate，it worth promoting.

[Key words] Lidocaine ；Lung cancer chemotherapy ；Intractable hiccup

頑固性呃逆（IH）是肺癌化療患者的常見并發癥，臨床常用的吉西他濱、長春瑞濱、異環磷酰胺、順鉑、表柔比星等肺癌常用化療藥物都對胃腸道有不良影響，對中樞神經、迷走神經具有刺激性，容易引起呃逆[1]。而且肺癌患者久病體虛、脾胃不和、痰瘀氣滯等因素都會引起IH。IH不僅影響患者的正常進食和睡眠，而且會降低患者對化療的信心，甚至中斷化療，產生嚴重不利影響。所以，安全有效的IH治療措施對患者的預后至關重要。臨床針對IH主要采用抗膽堿藥、中樞神經興奮藥、鈣離子拮抗劑、增強胃動力藥物、麻醉劑等藥物進行治療，不同藥物的療效有明顯差異[2]。……