
摘要:目的 通過對比冠狀動脈慢血流組與血流正常組中的高敏性C-反應蛋白水平,探討冠狀動脈慢血流與炎性因子的相關性。方法 入選198例冠狀動脈造影未見明顯狹窄的患者,測定TIMI血流及校正TIMI幀數計數,分為冠狀動脈血流緩慢組96例,血流正常組102例,檢測高敏性C-反應蛋白的水平。結果 冠狀動脈慢血流組,高敏性C-反應蛋白的水平高于血流正常組,相關分析顯示冠脈血流速度與炎性因子水平呈負相關(P<0.05)。結論 冠狀動脈慢血流組患者血管炎性因子水平高于血流正常組。
關鍵詞:C-反應蛋白;冠狀動脈;慢血流
High-Sensitivity C-Reactive Protein in Patients with Coronary Slow Flow in the Application
XU Ming,GAO Li-li,LI Zhi-jun
(Changji Prefecture People's Hospital,Changji 831100,Xinjiang,China)
Abstract:Objective Through compare coronary slow blood flow in the group with normal blood flow to the patient's C-reactive protein levels in High sensitivity, explore coronary slow flow and vascular inflammatory factor correlation and clinical significance. Methods Selected 198 cases of coronary angiography not seen significant stenosis, determination of number of TIMI flow and corrected TIMI frame count, divided the patients into 96 cases of coronary artery blood stream is slow group, normal blood flow to the group of 102 cases, detect High sensitivity C - reactive protein level. Results The coronary artery blood flow to slow group, High sensitivity C - reactive protein levels, results show that the vessels inflammatory factor levels higher than normal group, the relevant analysis showed that coronary artery blood flow velocity and blood vessels was negatively (P< 0.05). Conclusion The patients with coronary slow flow group vessels inflammatory factor levels higher than normal group.
Key words:C-reactive protein;Coronary artery;Slow blood flow
冠狀動脈慢血流現象(CSFP)是指排除冠狀動脈擴張、冠狀動脈成型術后、冠狀動脈痙攣等因素,行冠狀動脈造影未發現冠脈血管有明顯狹窄,卻存在造影劑通過緩慢,血管遠端灌注延遲的現象。對因心臟不適患者行冠脈造影經常會發現CSFP,常會因冠狀動脈未見明顯狹窄忽視此種情況,但進行隨訪,會發現部分患者仍會出現不適,甚至發生急性心肌梗死等嚴重的心血管事件。近年來開始重視并不斷認識CSFP,其中包括炎癥與冠狀動脈慢血流的關系。C-反應蛋白是人體非特異性炎癥反應中主要的、最敏感的標志物之一,通過對比冠狀動脈慢血流與血流正常患者的C-反應蛋白的水平,旨在探討炎性因子與冠脈慢血流之間的關系,加深對冠狀動脈慢血流的的認識,提高對冠狀動脈疾病的早期預測價值。
1 資料與方法
1.1一般資料 2013年4月~2015年3月在我院住院患者198例,年齡在35~70歲,因胸悶、胸痛為主要表現被擬診為冠心病,制定排除標準,如曾行冠狀動脈內支架置入術或冠狀動脈旁路移植術等;……