凍融胚胎移植不同內(nèi)膜準(zhǔn)備方案對(duì)不明原因反復(fù)種植失敗患者妊娠結(jié)局的影響

鄒志玲 鄧智心 陳 博 陳雪梅

摘? ?要：目的? 探討不同凍融胚胎移植內(nèi)膜準(zhǔn)備方案對(duì)不明原因反復(fù)種植失敗患者子宮內(nèi)膜容受性及妊娠結(jié)局的影響。方法? 回顧分析2016年7月～2018年7月在東莞市第三人民醫(yī)院生殖中心不明原因反復(fù)種植失敗≥2次，行凍融胚胎移植的30例患者的臨床資料。本周期自身配對(duì)比較，按子宮內(nèi)膜準(zhǔn)備方案分組：其中30周期設(shè)為HRT組，25周期設(shè)為NC組，38周期設(shè)為GnRHa-HRT組。結(jié)果? NC組與HRT組、GnRHa-HRT組子宮內(nèi)膜厚度比較，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。GnRHa-HRT組臨床妊娠率、胚胎種植率、繼續(xù)妊娠率明顯高于HRT組、NC組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論? NC組比HRT組在凍融周期臨床妊娠率有提高的趨勢(shì)，GnRHa-HRT方案可以顯著提高凍融周期胚胎反復(fù)種植失敗患者的臨床妊娠率。

關(guān)鍵詞：凍融胚胎移植;反復(fù)種植失敗;內(nèi)膜準(zhǔn)備;子宮內(nèi)膜容受性

中圖分類號(hào)：R714? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 文獻(xiàn)標(biāo)識(shí)碼：A? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? DOI：10.3969/j.issn.1006-1959.2018.21.025

文章編號(hào)：1006-1959（2018）21-0094-03

Pregnancy Outcome in Patients with Unexplained Recurrent Implantation Failure of Frozen Thawed Embryo Transfer in Different Endometrial Preparation

ZOU Zhi-Ling1，DENG Zhi-xin1，CHEN Bo2，CHEN Xue-mei2

（1.Graduate School of Guangdong Medical University，Zhanjiang 254023，Guangdong，China;

2.Reproductive Center of the Third People's Hospital of Dongguan City，Dongguan 523326，Guangdong，China）

Abstract：Objective? To investigate the effect of Pregnancy outcome in patients with unexplained recurrent implantation failure of frozen thawed embryo transfer in different endometrial preparation. Methods? Retrospective analysis of the failure of repeated planting of ≥2 times in the reproductive center of the Third People's Hospital of Dongguan from July 2016 to July 2018，clinical data of 30 cases of frozen and thawed embryo transfer. According to the endometrial preparation scheme， 30 cycles were divided into HRT group， 25 cycles as NC group and 38 cycles as GnRHa-HRT group.Results? The difference in endometrial thickness between the NC group and the HRT group and the GnRHa-HRT group was statistically significant （P<0.05）.The clinical pregnancy rate， embryo implantation rate and continued pregnancy rate in GnRHa-HRT group were significantly higher than those in HRT group and NC group （P<0.05）. Conclusion? The clinical pregnancy rate of the NC group is higher than that of the HRT group during the freeze-thaw cycle. The GnRHa-HRT program can significantly improve the clinical pregnancy rate of patients with failed embryo implantation in the freeze-thaw cycle.

Key words：Frozen-thawed embryo transfer;Recurrent implantation failure;Endometrial preparation; Endometrial receptivity