胡興蓮 謝明杰
【摘要】目的 研究頭部亞低溫不同治療時間對新生兒中重度缺氧缺血性腦病的療效。方法 選取我院2015年3月~2017年3月收治的新生兒中重度缺氧缺血性腦病患兒96例,均采用頭部亞低溫治療,根據(jù)不同的治療時間,分為48 h組、72 h組、96 h組,各32例。所有患兒均在出生后6 h內(nèi)開始治療。患兒出生后28 d采用NBNA評分進(jìn)行評定,并對比三組患兒不良反應(yīng)。結(jié)果 三組患兒中,72 h組患兒28 d的NBNA評分(39.8±3.5)分,高于其它兩組;差異有統(tǒng)計學(xué)意義(P<0.05)。三組患兒中,96 h組患兒不良反應(yīng)發(fā)生率為62.50%,高于其它兩組;差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 對新生兒中重度缺氧缺血性腦病,采取頭部亞低溫治療,持續(xù)治療72 h效果最理想,且不良反應(yīng)少。
【關(guān)鍵詞】頭部亞低溫;治療時間;新生兒;中重度缺氧缺血性腦病
【中圖分類號】R72 【文獻(xiàn)標(biāo)識碼】A 【文章編號】ISSN.2095-6681.2018.18..02
【Abstract】Objective To study the therapeutic effect of head mild hypothermia for moderate and severe hypoxic ischemic encephalopathy (HIE) in neonates.Methods 96 neonates with moderate and severe hypoxic-ischemic encephalopathy were selected from March 2015 to March 2017.All of them were treated with mild hypothermia.According to different treatment time,they were divided into 48 h group,72 h group and 96 h group,32 cases in each group.All the children were treated within 6 hours after birth.28 days after birth,the children were assessed with NBNA score,and the adverse reactions were compared among the three groups.Results The NBNA score of 28 days in 72h group (P<0.05).The score of 39.8±3.5 was higher than that of the other two groups (P<0.05).The incidence of adverse reactions in 96 h group was 62.50,higher than that in the other two groups (P<0.05).Conclusion For moderate and severe hypoxic ischemic encephalopathy of newborn,head mild hypothermia therapy is the most effective treatment for 72 hours,and the adverse reaction is less.
【Key words】Head mild hypothermia;Treatment time;Newborn;Moderate and severe hypoxic-ischemic encephalopathy
新生兒缺氧缺血性腦病,容易造成新生兒傷殘或死亡。該病有復(fù)雜的發(fā)病機(jī)制,以往僅可對癥治療和支持治療。隨著醫(yī)療技術(shù)及理念的進(jìn)步,通過動物試驗(yàn)和初步臨床,證實(shí)可采用亞低溫方法治療新生兒缺氧缺血性腦病,可取得一定的療效[1-2]。一般情況下,在患兒缺氧缺血損傷出現(xiàn)后的6 h內(nèi)開始治療,不過,對于治療時間方面,目前仍存在一定的爭議。基于此,本文選擇醫(yī)院收治的新生兒中重度缺氧缺血性腦病患兒96例,研究了頭部亞低溫不同治療時間對新生兒中重度缺氧缺血性腦病的療效。現(xiàn)報告如下。
1 資料與方法
1.1 一般資料
選取我院2015年3月~2017年3月收治的新生兒中重度缺氧缺血性腦病患兒96例,其中有男54例,女42例,均采用頭部亞低溫治療,根據(jù)不同的治療時間,分為48 h組、72 h組、96 h組,各32例。納入標(biāo)準(zhǔn):符合新生兒中重度缺氧缺血性腦病的診斷標(biāo)準(zhǔn)及臨床分度標(biāo)準(zhǔn),患兒家屬對本研究知情同意,醫(yī)學(xué)倫理委員會批準(zhǔn)。……