丙硫氧嘧啶與甲巰咪唑治療Graves病甲狀腺功能亢進(jìn)癥的效果分析

馮耀然

[摘要] 目的 探討丙硫氧嘧啶與甲巰咪唑用于Graves病甲狀腺功能亢進(jìn)癥患者治療中的效果分析。 方法 ?從2017年10月～2019年10月在我院治療的甲狀腺功能亢進(jìn)癥患者200例中擇取70例Graves病甲狀腺功能亢進(jìn)癥患者作為基礎(chǔ)研究數(shù)據(jù)，按隨機(jī)原則分成對(duì)照組（n=35）及觀察組（n=35），對(duì)照組采取丙硫氧嘧啶，觀察組采用甲硫咪唑方案，分析組間治療效果、甲狀腺體積變化指標(biāo)、藥物使用后的不良反應(yīng)率。 結(jié)果 觀察組治療總有效率、治療前后甲狀腺體積變化幅度與對(duì)照組差異均無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）;觀察組治療后3個(gè)月不良反應(yīng)發(fā)生率顯著低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。 結(jié)論 Graves病甲狀腺功能亢進(jìn)癥的治療中使用丙硫氧嘧啶與甲巰咪唑兩種藥物，臨床各項(xiàng)指標(biāo)的改善情況均較為理想，可以將疾病控制在更加理想的范圍內(nèi)，可結(jié)合患者實(shí)際情況選擇藥物。

[關(guān)鍵詞] 丙硫氧嘧啶;甲巰咪唑;Graves病;甲狀腺功能亢進(jìn)癥

[中圖分類號(hào)] R581.1 ? ? ? ? ?[文獻(xiàn)標(biāo)識(shí)碼] B ? ? ? ? ?[文章編號(hào)] 1673-9701（2020）12-0122-03

[Abstract] Objective To investigate the effect of propylthiouracil and methimazole in the treatment of patients with Graves hyperthyroidism. Methods 70 patients with Graves hyperthyroidism from 200 patients with hyperthyroidism treated in our hospital from October 2017 to October 2019 were selected as basic research subjects and divided into the control group（n=35） and the observation group（n=35） according to the random principle. The control group was treated with propylthiouracil. The observation group was treated with methimazole. The treatment effects， indicators of thyroid volume change， and adverse reaction rates after drug use between groups were analyzed. Results There was no significant difference in the total effective rate of treatment， the change in thyroid volume before and after treatment between the observation group and the control group（P>0.05）. The incidence of adverse reactions at 3 months after treatment in the observation group was significantly lower than that in the control group， and the difference was statistically significant（P<0.05）. Conclusion The propylthiouracil and methimazole in the treatment of Graves hyperthyroidism can make the improvement of clinical indicators satisfactory. The disease can be controlled in a more ideal range and one drug can be chosen combined with the actual situation of patients.?

[Key words] Propylthiouracil; Methimazole; Graves disease; Hyperthyroidism

Graves病又稱為彌漫性甲狀腺腫伴功能亢進(jìn)癥，突眼性甲狀腺腫等，屬于一種毒性彌漫性甲狀腺免疫系統(tǒng)疾病，但是其臨床表現(xiàn)較多，不僅表現(xiàn)在甲狀腺方面，還可能存在代謝方面、皮膚方面的疾病，對(duì)患者的危害較為嚴(yán)重，引發(fā)精神異常、視覺(jué)、心腦血管、血液及消化等各個(gè)方面的疾病，對(duì)生命健康造成嚴(yán)重的威脅[1]。Graves病甲狀腺功能亢進(jìn)屬于內(nèi)分泌系統(tǒng)疾病，患者因?yàn)榧谞钕偌に胤置谶^(guò)多，造成交感神經(jīng)的代謝處于一種異常的狀……