肝動(dòng)脈化療栓塞介入術(shù)對(duì)原發(fā)性肝癌患者近期療效及Child-Pugh分級(jí)的影響

王瑞航 姚升娟 張晨

摘要：目的 ?探討肝動(dòng)脈化療栓塞介入術(shù)（TACE）對(duì)原發(fā)性肝癌患者近期療效及Child-Pugh分級(jí)的影響。方法 ?收集我院2018年9月～2019年7月收治的95例原發(fā)性肝癌患者臨床資料，根據(jù)其治療方式分為對(duì)照組（n=46）與觀察組（n=49）。對(duì)照組行射頻消融術(shù)治療，觀察組行TACE治療，比較兩組近期療效、Child-Pugh分級(jí)及不良反應(yīng)總發(fā)生率。結(jié)果 ?觀察組總有效率高于對(duì)照組，Child-Pugh分級(jí)優(yōu)于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）;兩組不良反應(yīng)總發(fā)生率比較，差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）。結(jié)論 ?原發(fā)性肝癌患者應(yīng)用TACE治療近期療效較佳，可有效改善Child-Pugh分級(jí)，且安全性高，不良反應(yīng)少。

關(guān)鍵詞：原發(fā)性肝癌;肝動(dòng)脈化療栓塞介入術(shù);陀螺刀放射;近期療效;Child-Pugh分級(jí)

中圖分類(lèi)號(hào)：R735.7 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 文獻(xiàn)標(biāo)識(shí)碼：A ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? DOI：10.3969/j.issn.1006-1959.2020.17.029

文章編號(hào)：1006-1959（2020）17-0101-02

Abstract：Objective ?To explore the effect of hepatic artery chemoembolization intervention （TACE） on the short-term curative effect and Child-Pugh classification of patients with primary liver cancer.Methods ?The clinical data of 95 patients with primary liver cancer admitted in our hospital from September 2018 to July 2019 were collected and divided into control group （n=46） and observation group （n=49） according to their treatment methods. The control group was treated with radiofrequency ablation， and the observation group was treated with TACE. The short-term curative effect， Child-Pugh classification and total incidence of adverse reactions were compared between the two groups. Results ?The total effective rate of the observation group was higher than that of the control group， and the Child-Pugh classification was better than that of the control group，the difference was statistically significant （P<0.05）; the total incidence of adverse reactions between the two groups was not statistically significant （P>0.05）.Conclusion ?TACE treatment for patients with primary liver cancer has better short-term curative effect， can effectively improve Child-Pugh classification， and has high safety and few adverse reactions.

Key words：Primary liver cancer;Hepatic artery chemoembolization intervention;Gyro knife radiation;Short-term efficacy;Child-Pugh classification

原發(fā)性肝癌（primary liver cancer）具有病情隱匿、病情發(fā)展緩慢等特點(diǎn)，大部分患者察覺(jué)就診時(shí)病情已處于中晚期，喪失最佳手術(shù)時(shí)機(jī)[1]。既往臨床針對(duì)中晚期原發(fā)性肝癌多采用化療藥物治療，其雖具有良好抑制作用，但毒副反應(yīng)較多，患者耐受度較差，故應(yīng)用存在較強(qiáng)局限性。隨著介入治療技術(shù)的發(fā)展，肝動(dòng)脈化療栓塞介入術(shù)（TACE）逐步應(yīng)用于原發(fā)性肝癌治療中，其通過(guò)將化療藥物灌注于腫瘤供血?jiǎng)用}內(nèi)，以促使腫瘤細(xì)胞缺血壞死，具有良好應(yīng)用效果[2]。但目前臨床對(duì)其治療近期療效及對(duì)Child-Pugh分級(jí)報(bào)道較少，鑒于此，本研究旨在探討TACE對(duì)原發(fā)性肝癌患者近期療效及Child-Pugh分級(jí)的影響，現(xiàn)報(bào)道如下。

1資料與方法

1.1 一般資料 ?收集天津市第二人民醫(yī)院2018年9月～2019年7月收治的95例原發(fā)性肝癌患者臨床資料，根據(jù)其治療方式分為對(duì)照組（n=46）與觀察組（n=49）。……