肝動脈化療栓塞介入術對原發性肝癌患者近期療效及Child-Pugh分級的影響

王瑞航 姚升娟 張晨

摘要：目的 ?探討肝動脈化療栓塞介入術（TACE）對原發性肝癌患者近期療效及Child-Pugh分級的影響。方法 ?收集我院2018年9月～2019年7月收治的95例原發性肝癌患者臨床資料，根據其治療方式分為對照組（n=46）與觀察組（n=49）。對照組行射頻消融術治療，觀察組行TACE治療，比較兩組近期療效、Child-Pugh分級及不良反應總發生率。結果 ?觀察組總有效率高于對照組，Child-Pugh分級優于對照組，差異有統計學意義（P<0.05）;兩組不良反應總發生率比較，差異無統計學意義（P>0.05）。結論 ?原發性肝癌患者應用TACE治療近期療效較佳，可有效改善Child-Pugh分級，且安全性高，不良反應少。

關鍵詞：原發性肝癌;肝動脈化療栓塞介入術;陀螺刀放射;近期療效;Child-Pugh分級

中圖分類號：R735.7 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 文獻標識碼：A ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? DOI：10.3969/j.issn.1006-1959.2020.17.029

文章編號：1006-1959（2020）17-0101-02

Abstract：Objective ?To explore the effect of hepatic artery chemoembolization intervention （TACE） on the short-term curative effect and Child-Pugh classification of patients with primary liver cancer.Methods ?The clinical data of 95 patients with primary liver cancer admitted in our hospital from September 2018 to July 2019 were collected and divided into control group （n=46） and observation group （n=49） according to their treatment methods. The control group was treated with radiofrequency ablation， and the observation group was treated with TACE. The short-term curative effect， Child-Pugh classification and total incidence of adverse reactions were compared between the two groups. Results ?The total effective rate of the observation group was higher than that of the control group， and the Child-Pugh classification was better than that of the control group，the difference was statistically significant （P<0.05）; the total incidence of adverse reactions between the two groups was not statistically significant （P>0.05）.Conclusion ?TACE treatment for patients with primary liver cancer has better short-term curative effect， can effectively improve Child-Pugh classification， and has high safety and few adverse reactions.

Key words：Primary liver cancer;Hepatic artery chemoembolization intervention;Gyro knife radiation;Short-term efficacy;Child-Pugh classification

原發性肝癌（primary liver cancer）具有病情隱匿、病情發展緩慢等特點，大部分患者察覺就診時病情已處于中晚期，喪失最佳手術時機[1]。既往臨床針對中晚期原發性肝癌多采用化療藥物治療，其雖具有良好抑制作用，但毒副反應較多，患者耐受度較差，故應用存在較強局限性。隨著介入治療技術的發展，肝動脈化療栓塞介入術（TACE）逐步應用于原發性肝癌治療中，其通過將化療藥物灌注于腫瘤供血動脈內，以促使腫瘤細胞缺血壞死，具有良好應用效果[2]。但目前臨床對其治療近期療效及對Child-Pugh分級報道較少，鑒于此，本研究旨在探討TACE對原發性肝癌患者近期療效及Child-Pugh分級的影響，現報道如下。

1資料與方法

1.1 一般資料 ?收集天津市第二人民醫院2018年9月～2019年7月收治的95例原發性肝癌患者臨床資料，根據其治療方式分為對照組（n=46）與觀察組（n=49）。……