慢性酒精中毒性腦病的臨床診治分析

高中德　修芳芳

[摘要] 目的 探究采用不同方法治療慢性酒精中毒性腦病的療效，并對診斷學特征進行匯總分析。方法 方便選擇該院2017年4月—2019年4月收治的40例慢性酒精中毒性腦病患者。按照治療方法不同將所有研究對象分為參考組、實驗組，每組20例。予以參考組患者維生素B1治療，予以實驗組患者維生素B1+醒腦靜聯合治療。匯總所有患者的診斷學特征，比較兩組患者的療效、簡易精神狀態檢查量表（MMSE）評分、生活質量量表（ADL）評分、不良反應發生情況等。結果 所有患者均存在頭部昏沉、心電異常情況。與參考組患者的70.0%相比較，實驗組患者治療總有效率95.0%更高，差異有統計學意義（χ2=4.329，P=0.037）。與參考組患者的30.0%相比較，實驗組患者不良反應發生率5.0%更低，差異有統計學意義（χ2=4.329，P=0.037）。結論 以維生素B1+醒腦靜聯合治療慢性酒精中毒性腦病患者效果確切，可有效改善患者病情，降低患者不良反應發生率。

[關鍵詞] 慢性酒精中毒;中毒性腦病;臨床診治

[中圖分類號] R595.6? ? ? ? ? [文獻標識碼] A? ? ? ? ? [文章編號] 1674-0742（2020）09（b）-0031-03

Analysis of Clinical Diagnosis and Treatment of Chronic Alcoholic Encephalopathy

GAO Zhong-de， XIU Fang-fang

Substance Dependence Department， Yantai Psychological Rehabilitation Hospital， Yantai， Shandong Province， 265200 China

[Abstract] Objective To explore the efficacy of different methods in the treatment of chronic alcoholic encephalopathy， and to analyze the diagnostic features. Methods The 40 study subjects were selected from patients with chronic alcoholic encephalopathy who were admitted to the hospital from April 2017 to April 2019. According to different treatment methods， all research subjects were divided into two groups： reference group and experimental group， with 20 cases in each group. Patients in the reference group were treated with vitamin B1， and patients in the experimental group were treated with vitamin B1 and Xingnaojing. Summarize the diagnostic characteristics of all patients， compare the curative effect， Mini Mental State Examination Scale （MMSE） score， Quality of Life Scale （ADL） score， and adverse reactions between the two groups of patients. Results All patients had head dizziness and abnormal ECG. Compared with 70.0% of patients in the reference group， the total effective rate of treatment in the experimental group was 95.0% higher， the difference was statistically significant（χ2=4.329， P=0.037）. Compared with 30.0% of patients in the reference group， the adverse reaction rate of patients in the experimental group was 5.0% lower， the difference was statistically significant（χ2=4.329， P=0.037）. Conclusion The combination of vitamin B1 and Xingnaojing is effective in treating patients with chronic alcoholic encephalopathy， which can effectively improve the patient's condition and reduce the incidence of adverse reactions in patients.

[Key words] Chronic alcoholism; Encephalopathy; Clinical diagnosis and treatment

酒精中毒性腦病分急、慢性兩種，其中慢性酒精中毒性腦病是一種常見病，是因長期過量飲酒導致機體營養代謝失衡，從而持久、嚴重損傷肝腎、心血管、中樞神經系統等的疾病，是酒精濫用、酒精中毒患者的重要疾病表現[1]。因酒精中毒所致，患者可出現基底節供血不足情況，還可出現氧代謝抑制、細胞變性萎縮等情況，甚至出現類帕金森征，有研究證實，患者因供血不足、慢性中毒性退化、變性及萎縮等所致，均存在一定小腦萎縮情況。……