自擬益氣養陰清利方治療慢性腎炎蛋白尿的療效觀察

陳建萍

摘 要 目的：觀察自擬益氣養陰清利方治療慢性腎炎蛋白尿的臨床療效。方法 選取2015年10月至2017年2月收治的慢性腎炎蛋白尿患者60例，按照隨機數字表法分為對照組和治療組各30例。在常規治療基礎上，對照組口服腎炎康復片治療，每天3次，每次5片；治療組給予自擬益氣養陰清利方治療，用水煎服，每天1劑（400 mL），分早晚2次溫服；兩組均治療3個月。比較兩組患者的療效、中醫證候評分、實驗室檢查指標及治療期間的不良反應發生情況。結果 治療組總有效率為87.1%（24/30），高于對照組的43.0%（13/30，P<0.05）。 治療后，治療組的尿液紅細胞數量、24 h尿蛋白定量低于對照組，且中醫證候評分改善亦優于對照組（P<0.05）。結論 治療組的實驗室指標和中醫證候評分改善效果及療效較好。

關鍵詞 慢性腎炎；蛋白尿；中醫藥治療；益氣養陰清利方

中圖分類號：R277 文獻標志碼：A 文章編號：1006-1533（2021）20-0027-03

基金項目：上海市靜安區衛生及健康委員會中醫藥三年行動計劃（杏林新星JA2015-R002）

Observation of therapeutic effect of self-made Yiqi yangyin qingli recipe in the treatment of chronic nephritis proteinuria

CHEN Jianping

（Department of Traditional Chinese Medicine of Gonghui Hospital， Shanghai 200041， China）

ABSTRACT Objective： To observe the clinical effect of Yiqi yangyin qingli recipe in the treatment of chronic nephritis proteinuria. Methods： Sixty patients with chronic nephritis proteinuria treated from October 2015 to February 2017 were selected and according to the random number table method， divided into a control group and a treatment group with 30 cases in each group. On the basis of conventional treatment， the control group was treated with Shenyankangfu tablets， 3 times a day， 5 tablets each time； the treatment group was treated with self-made Yiqi yangyin qingli recipe， decocted with water， 1 dose （400 mL） a day， twice in the morning and evening； both groups were treated for 3 months. The curative effect， TCM syndrome score， laboratory test indicators and adverse reactions during the treatment period were compared between the two groups. Results： The total effective rate of the treatment group was 87.1% （24 / 30）， which was higher than that of the control group 43.0% （13 / 30 P<0.05）. After treatment， the number of urine red blood cells and 24-hour urine protein quantitative of the treatment group were lower than those of the control group， and the improvement of TCM syndrome score of the treatment group was also better than that of the control group （P<0.05）. Conclusion： The improvement effect and curative effect of laboratory indexes and TCM syndrome score of the treatment group are better.

KEY WORDS chronic nephritis； proteinuria； traditional Chinese medicine treatment； Yiqi yangyin qingli recipe

近年來，隨著我國社會經濟發展及人們生活節奏日益加快，生活水平逐漸提高，慢性腎炎蛋白尿患者的發病人數呈逐年上升趨勢。慢性腎炎蛋白尿患者持續存在的大量蛋白尿是慢性腎炎不良預后的危險因素。因此，對于慢性腎炎患者，阻止尿蛋白漏出是治療的一大重點。中醫學理論認為，慢性腎炎蛋白尿隸屬祖國醫學“石水”“虛勞” “精微外泄”范疇，主要病機特點為本虛標實證，脾腎氣虛為本，風邪、濕熱、瘀毒為標，濕熱貫穿于病程的始終。本研究觀察自擬益氣養陰清利方治療慢性腎炎蛋白尿的臨床療效，現報道如下。