心肌標志物、MPV、PDW和血清sCD36、sCD40L對冠心病的診斷價值

那軒與 范越男 彭程 王柏山 張程

[關鍵詞] 心肌標志物;血常規;冠心病;心肌肌鈣蛋白

[中圖分類號] R541? ? ? ? ? [文獻標識碼] A? ? ? ? ? [文章編號] 1673-9701（2021）25-0020-04

Diagnostic value of myocardial markers， MPV， PDW， serum sCD36 and sCD40L for coronary heart disease

NA Xuanyu? ?FAN Yuenan? ?PENG Cheng? ?WANG Baishan? ?ZHANG Cheng

Department of Laboratory Medicine， Affiliated Hospital of Liaoning University of Traditional Chinese Medicine， Shenyang? ?110031， China

[Abstract] Objective To explore the diagnostic value of myocardial markers，MPV，PDW， serum sCD36， sCD40L and other indicators for coronary heart disease. Methods A total of 150 patients with coronary heart disease treated in our hospital from June 2018 to July 2019，and 150 healthy medical examiners were selected. They were tested for myocardial markers，blood count， sCD36 and sCD40L，to compare the diagnostic coincidence rates of different diagnosis methods. Results The indexes of cTnI， CK-MB and cTnT in the observation group were significantly higher than those in the control group，with significant difference（P<0.05）. The RDW index in the observation group were significantly higher than that in the control group，with significant difference（P<0.05）. There were no significant differences in blood count results， including PDW， PLT， MPV and PCT between the two groups（P>0.05）. The expression levels of serum sCD36 and sCD40L in the observation group were significantly higher than those in the control group，with significant difference（P<0.001）. Conclusion? The myocardial markers cTnI， CK-MB and cTnT， RDW， and serum sCD36 and sCD40L all change abnormally in patients with coronary heart disease. They can be used as disease diagnosis indicators.

[Key words] Myocardial markers; Blood count; Coronary heart disease; Cardiac troponin

冠心病為常見慢性疾病，主要指冠狀動脈粥樣硬化所引發的冠狀動脈管腔狹窄及阻塞性疾病，患者常會出現心肌缺血、缺氧反應，有較高致死率，需早期診斷、治療。患者臨床多表現為胸痛、心絞痛，治療不當則會危及生命安全。臨床主要診斷方式為冠狀動脈造影、超聲心動圖等，雖然診斷符合率較高，但選擇有效的輔助性診斷方式也十分重要。研究發現，血常規和心肌標志物均可用于冠心病診斷，但具體診斷效果卻并無全方位分析[1]。為提升疾病診斷符合率，現選取我院患者和體檢人員為研究對象，分析患者心肌標志物心肌肌鈣蛋白I（Cardiac troponin I，cTnI）、肌酸激酶同工酶（Creatine kinase isoenzyme，CK-MB）、心肌肌鈣蛋白T（Cardiac troponin T，cTnT）、平均血小板體積（Mean platelet volume，MPV）、血小板體積分布寬度（Platelet volume distribution width，PDW）、紅細胞體積分布寬度（Red blood cell volume distribution width，RDW）、血清可溶性CD36（Soluble CD36，sCD36）及可溶性CD40配體（soluble CD40 ligand，sCD40L）等指標，探討不同診斷方式效果，現報道如下。

1 資料與方法