抗青光眼藥物的使用與淚液MUC5AC含量及眼表改變的影響研究

趙璐

[摘要] 目的 為了探究抗青光眼藥物的使用對(duì)于青光眼患者淚液MUC5AC含量及眼表改變的實(shí)踐影響，從而為青光眼的臨床治療提供借鑒和依據(jù)。 方法 本次研究選取我院2009年12月～2010年12月期間收治并實(shí)施藥物治療的青光眼患者48例（48眼）為青光眼患者組，同時(shí)選取同期體檢的無(wú)青光眼的健康人群48例為健康對(duì)照組。觀察并比較兩組人群的淚液MUC5AC含量以及眼表功能評(píng)分結(jié)果。 結(jié)果 （1）健康對(duì)照組研究對(duì)象的MUC5AC含量明顯高于青光眼患者組實(shí)施治療3個(gè)月以及6個(gè)月后的水平，且組間數(shù)據(jù)比較差異具有顯著的統(tǒng)計(jì)學(xué)意義（t=2.4519，P=0.0161；t=3.7697，P=0.0003）；青光眼患者治療6個(gè)月后的MUC5AC含量顯著低于治療3個(gè)月后的水平，且數(shù)據(jù)差異具有顯著的統(tǒng)計(jì)學(xué)意義（t=2.1543，P=0.0338）；（2）健康對(duì)照組研究對(duì)象的眼表功能評(píng)分結(jié)果明顯低于青光眼患者組實(shí)施治療3個(gè)月以及6個(gè)月后的水平，且組間數(shù)據(jù)比較差異具有顯著的統(tǒng)計(jì)學(xué)意義（z=-7.013，P=0.000；z=-8.485，P=0.000）；青光眼患者治療6個(gè)月后的眼表功能評(píng)分顯著高于治療3個(gè)月后的水平，且數(shù)據(jù)差異具有顯著的統(tǒng)計(jì)學(xué)意義（z=-3.578，P=0.000）。 結(jié)論 長(zhǎng)期的抗青光眼藥物治療可導(dǎo)致患者的淚液MUC5AC減少及眼表?yè)p害，并且隨著藥物治療時(shí)間的延長(zhǎng)，損害也不斷加劇。

[關(guān)鍵詞] 抗青光眼藥物；淚液MUC5AC；眼表改變

[中圖分類(lèi)號(hào)] R775 [文獻(xiàn)標(biāo)識(shí)碼] B [文章編號(hào)] 1673-9701（2014）32-0124-02

Study on the effects of MUC5AC content and tear and ocular surface changes of anti-glaucoma drugs

ZHAO Lu

Department of Ophthalmology， Luohu Hospital of Shenzhen City， Shenzhen 518000，China

[Abstract] Objective In order to explore the practice effect of the MUC5AC content of tear and ocular surface changes of the glaucoma patient who used anti-glaucoma drug treatment， to provide reference and basis for the clinical treatment of glaucoma. Methods Selected 48 patients with glaucoma who received the implementation of drug treatment in our hospital from December 2009 to December 2010 as glaucoma group， and selected 48 healthy people as healthy control group at the same time. Evaluation results were compared between the two groups in tear MUC5AC content and ocular surface function. Results （1） MUC5AC in control group was significantly higher than that of healthy subjects with glaucoma group three or six months after treatment， with significant statistical significance between group differences and data （t=2.4519， P=0.0161； t=3.7697， P=0.0003）； The content of MUC5AC in glaucoma patients after treatment was significantly lower than that of three or six months after treatment， a statistically significant difference （t=2.1543， P=0.0338）； （2）Healthy ocular surface function group study score was significantly lower than in patients with glaucoma group treatment three or six months after treatment， with significant statistical significance between group data and compared the difference （z=-7.013，P=0.000；z=-8.485，P=0.000）； Ocular surface function in patients with glaucoma treatment six years later， the scores were significantly higher than the scores three months after treatment， the difference was statistically significant（z=-3.578，P=0.000）. Conclusion Anti-glaucoma medication for a long time can lead to the decrease of tear MUC5AC and the damage of ocular surface，and the bad situation will get worse while the drug treatment prolonged.endprint