精神分裂癥難治性陰性癥狀的治療方式及效果探究

[摘要] 目的 研究精神分裂癥難治性陰性癥狀的治療方式及效果。方法 方便選取該院2015年3月—2016年5月精神分裂癥難治性陰性癥狀患者88例隨機分兩組。藥物組（44例）單純采用藥物治療，藥物+康復組（44例）采用藥物治療和康復治療。比較兩組患者精神分裂癥難治性陰性癥狀治療總有效率；TESS量表不良反應發生情況；治療之前和治療之后患者GQOLI-74生活質量量表中物質生活、心理健康、軀體健康和社會功能評分的差異。結果 藥物+康復組患者精神分裂癥難治性陰性癥狀治療總有效率高于藥物組（P<0.05）；兩組患者TESS量表不良反應發生情況差異無統計學意義，藥物組有1例主訴頭痛，藥物+康復組無異常癥狀，所有患者均可耐受且堅持完成療程，治療前后心電圖、血生化、血常規和腦電圖檢查均正常（P>0.05）；治療之前兩組GQOLI-74生活質量量表中物質生活、心理健康、軀體健康和社會功能評分比較差異無統計學意義（P>0.05）；治療之后兩組相關指標均顯著改善，但藥物+康復組改善幅度更大（P<0.05）。 結論 精神分裂癥難治性陰性癥狀給予藥物和康復治療效果確切，可有效改善陰性癥狀，提高患者生活質量，且無明顯不良反應，值得推廣。

[關鍵詞] 精神分裂癥；難治性陰性癥狀；治療方式；效果

[中圖分類號] R749.3 [文獻標識碼] A [文章編號] 1674-0742（2016）12（c）-0094-03

[Abstract] Objective To study the schizophrenia negative symptom treatment and effect. Methods Convenient selection our hospital in March 2015 to May 2016 schizophrenia patients with refractory symptoms of 88 cases were negative were randomly divided into two groups. Treatment group（44 cases） treated with medication， drug rehabilitation group（44 cases） received drug treatment and rehabilitation treatment. Compared two groups of patients refractory schizophrenia negative symptoms of the total efficiency of treatment TESS scale； the incidence of adverse reactions before and after treatment； treatment of patients with GQOLI-74 quality of life scale in material life， mental health， physical health and social function score difference. Results The results of drug rehabilitation group patients refractory schizophrenia negative symptoms total treatment efficiency is higher than the drug group，（P < 0.05）； two groups of patients with TESS scale adverse reactions no significant difference between drug group 1 patients complained of headache and drug rehabilitation group showed no abnormal symptoms， All patients can tolerate and to complete the course， before and after the treatment， electrocardiogram， blood biochemistry， blood routine and EEG were normal，（P > 0.05）； two groups before treatment GQOLI-74 quality of life scale in the material life， mental health， there is no significant difference between physical health and social function score（P>0.05）； after treatment of two groups of related index were significantly improved， but the drug rehabilitation group improved more significantly（P<0.05）. Conclusion Refractory schizophrenia negative symptoms given medication and rehabilitation treatment can improve negative symptoms， improve the quality of life of patients， and no significant adverse reactions， worthy of promotion.

[Key words] Schizophrenia； Refractory negative symptoms； Treatment mode； Effect

陰性癥狀為精神分裂患者常見癥狀之一，對患者社會功能的康復和生活質量的提高造成極大影響，是導致精神分裂癥患者殘疾的主要原因。因而，在對精神分裂癥患者的治療中，有效治療陰性癥狀是加速患者康復的重要目標。……