“易損斑塊無創、高分辨超聲功能與分子定量成像”研究2010年度報告

萬明習　宗瑜瑾　萬錦錦　吳道澄　谷曉林

摘要：本研究本年度在（1）高分辨超聲成像理論與方法、（2）微泡制備、高CTR造影成像及灌注參量成像、（3）血管及其周圍組織運動與彈性檢測成像、（4）超聲空化機理等四個方面研究取得重要進展。對高幀率、較高頻率超聲圖像分別進行了基于光流場（OF）的IBP超分辨重建和基于灰度非均勻校正的超分辨重建，重建后軸向及橫向分辨率可達到原始圖像的4倍以上；并在低成本數字超聲成像系統上實現了高CTR值的造影成像和灌注參量定量成像和脈沖逆轉小波變換造影成像技術；初步得到模仿人體生理pH環境下，聚焦超聲自由空化場中聲致發光（SL）的光學檢測實驗結果及聲致化學發光（SCL）的光學檢測實驗結果。

關鍵詞：超分辨重建；超聲造影成像；超聲空化；聲致發光；

Abstract：This year we make important progresses in following aspects： （1） Principle and methods of high resolution ultrasound imaging， （2）Preparation of microbubbles， ultrasound perfusion imaging with high CTR and perfusion parameter imaging， （3）motion and elasticity imaging of vascular and surrounding tissue， （4）mechanism of ultrasound cavition. The high frame rate and higher frequency ultrasound images have been made IBP super-resolution reconstruction based on optic flow and super-resolution reconstruction based on grey scale ununiformity correction， and the axial and lateral resolution after reconstruction can reach to four times higher than the original images. Additionally， ultrasound contrast imaging with high CTR， perfusion parameter quantitative imaging and pulse inverse wavelet transform contrast imaging have been realized on low cost digital ultrasound imaging system. Preliminary optical experimental results of sonoluminesence （SL） and sonochemoluminesence （SCL） in focused ultrasound free cavitation field have been obtained in a pH similar to human physiological environment.

Keywords：super-resolution reconstruction；ultrasound perfusion imaging；ultrasound cavitation；sonoluminesence