The relationship between central corneal thickness and intraocular pressure in healthy and glaucomatous eyes,a systematic review and Meta-analysis

Lungowe L.Bbumelo,Lang Bai

Name/yTypeLocationSizen1/n2Mean-age(SD)M/FMean-CCT1(SD)Mean-CCT2(SD)Mean-IOP1(SD)Mean-IOP2(SD)Molinaetal[10]2010observationalSpain6740/2765.5(11.49)unknown533.98(37.17)545.26(47.09)19.23(8.58)13.33(2.81)Desaintsardosetal[11]2009observationalCanada26431/23361.5(9.2)74/190560(37)557(35)17.1(4.6)16.0(3.3)Leeetal[12]2006observationalKorea567343/22457.2(12.6)288/279550.72(38.66)553.60(39.55)16.2(3.9)14.4(3.0)Yazdanietal[13]2015case-controlIran11862/5657(12)52/66552(34)562(41)18(4)14(2)Ozcuraetal[14]2015crosssectionalstudyGermany12468/5659.57(13.08)45/79527.84(42.16)541.71(39.86)15.88(3.82)16.14(3.81)Tianetal[15]2015crosssectionalstudyChina10242/6041.08(20.34)58/44547.69(36.95)546.65(28.02)15.62(2.35)14.9(1.73)Mangouritsasetal[16]2008prospectivestudyGreece182108/7462.4(9.8)83/99526.77(35.73)537.84(41.93)16.38(2.73)15.70(2.65)Realinietal[17]2009observationalstudyUSA8547/3870.0(12.8)30/55551(32)562(31)15.4(2.9)15.0(2.3)Abitboletal[18]2009observationalstudyFrance13358/7565.68(13.9)unknown535.34(42.7)560.2(36.3)17.1(5.1)15.9(2.6)Barleonetal[19]2006observationalstudyGermany197131/6624-8599/98542(36)544(31)20.7(8.4)13.3(3.1)Raoetal[20]2012crosssectionalstudyIndia13962/7751(17.7)73/66534(35.5)528(30.4)18(7.8)15(5.4)HirneiBetal[21]2011observationalstudyGermany3618/1864.4(11.0)9/9547.8(27.0)550.1(28.5)15.56(2.97)12.61(1.33)Rezniceketal[22]2013observationalstudyGermany178142/3661.3(4.5)unknown543.2(37.2)546.6(41.4)15.4(6.1)14.2(2.8)

CovariatesCoefficientsS.E.TPStudytype-0.37450.2288-1.640.130Samplesize-0.00030.0009-0.340.743Mean-age-0.00200.0164-0.120.908Femaleproportion-0.01920.0162-1.190.269

CovariatesCoefficientsS.E.tPStudytype0.06980.13840.500.624Samplesize0.00030.00040.860.407Agemean-0.02100.0080-2.620.025Femaleproportion-0.00770.0068-1.130.292