宮頸癌、卵巢癌患者梅毒螺旋體感染情況分析

何國霞 李紅梅

【摘要】目的：分析并探討婦科惡性腫瘤宮頸癌、卵巢癌的發生與感染梅毒螺旋體的關系。方法：選取2005年1月至2015年5月期間來我院接受治療的婦科惡性腫瘤宮頸癌658例、卵巢癌246例，檢測腫瘤患者梅毒螺旋體感染情況，分析婦科腫瘤宮頸癌和卵巢癌對梅毒螺旋體感染的發生影響。結果：658例宮頸癌患者中合并梅毒螺旋體感染患者68例（10.33%），246例卵巢癌患者合并梅毒螺旋體感染患者4例（1.63%）。宮頸癌合并梅毒螺旋體感染率明顯高于卵巢癌（P<0.05）。病理類型分析結果顯示，鱗癌患者594例，其中梅毒感染者68例，而腺癌56例、腺鱗癌8例患者中均無梅毒感染者；Ⅰ期腫瘤患者354例，梅毒感染58例；Ⅱ期304例，梅毒感染10例。年齡分析結果顯示，30～39歲136例，梅毒感染32例（23.53%）；40～49歲170例，梅毒感染30例（17.65%）；年齡50～59歲258例，梅毒感染6例（2.33%）；年齡60歲以上94例，梅毒感染0例。教育水平結果顯示，高中及高中以上264例，梅毒感染6例（2.27%）；高中以下394例，梅毒感染62例（15.74%）。結論：宮頸癌患者梅毒螺旋體感染率明顯高于卵巢癌患者，且與年齡、教育水平和病理類型、病理分期相關，為臨床防治提供理論支持。

【關鍵詞】宮頸癌；卵巢癌；梅毒螺旋體

Relationship between gynecological malignancies cervical cancer， ovarian cancer and syphlilisHE Guoxia1， LI Hongmei2. 1. Department of Obstetrics and Gynecology，Zhuji No.4 Peoples Hospital， Shaoxing 311835， Zhejiang， China； 2. Department of Obstetrics and Gynecology， Shaoxing Maternal and Children Care Hospital， Shaoxing 312000， Zhejiang， China

【Abstract】Objectives： To analyze and discuss the relationships between gynecological cervical cancer， ovarian cancer and infection of treponema pallidum. Methods： 658 cases of cervical cancer and 246 cases of ovarian cancer treated in our hospital from January 2005 to May 2015 were selected. Syphilis infection of these patients was detected. The impact of treponema pallidum infection on cervical cancer and ovarian cancer were analyzed. Results： In the 658 cases of cervical cancer， there were 68 cases of syphilis spirochete infection， accounting for 10.33%. In the 246 cases of ovarian cancer， there were 4 cases of syphilis spirochete infection， accounting for 1.63%. Syphilis infection rate in cervical cancer patients was significantly higher than that in ovarian cancer patients， with statistically significant difference （P<0.05）. Pathology analysis showed that there were 594 cases of squamous cell carcinoma， among which there were 68 cases of syphilis. In the 56 cases of adenocarcinoma and 8 cases of adeno-squamous cell carcinoma， there was no syphilis infection case. There were 58 cases of syphilis among 354 cases of staging I cancer. There were 10 cases of syphilis among 304 cases of staging II cancer. Age analysis showed that there were 136 cases in 30-39 years old patients， among which there were 32 cases of syphilis. In 40-49 years old patients， there were 170 cases， with 30 cases of syphilis. In 50-59 years old patients， there were 258 cases， with 6cases of syphilis. In over 60 years old patients， there were 94 cases， with 0 cases of syphilis. The level of education analysis results showed that there were 264 cases with high school or higher education level， among which there were 6 cases of syphilis. In patient with lower than high school education level， there were 394 cases， with 62 cases of syphilis. Conclusion： The prevalence of syphilis in patients with cervical cancer is significantly higher than that in ovarian cancer patients and is correlated with age， educational level， histological type and pathological staging， which provides theoretical support for the prevention and treatment.

【Key words】Cervical cancer； Ovarian cancer； Treponema pallidum

【中圖分類號】R737.3【文獻標志碼】A

子宮頸癌是最常見的婦科惡性腫瘤，而卵巢癌亦是女性生殖器常見的三大惡性腫瘤之一[1]，宮頸癌在發生發展過程中與人乳頭瘤病毒感染及性接觸均有一定相關性，而卵巢癌目前的研究則表明其與致癌及抑癌基因變異相關[2]。除人乳頭瘤病毒外，梅毒螺旋體因其性傳播的特點一直在宮頸癌及卵巢癌中備受關注[3]，在本次研究中，選取2005年1月至2015年5月期間來我院接受治療的婦科惡性腫瘤宮頸癌658例，卵巢癌246例，分析并探討婦科惡性腫瘤宮頸癌、卵巢癌的發生與感染梅毒螺旋體的關系。

1資料與方法

1.1一般資料

選取2005年1月至2015年5月期間來我院接受治療的婦科惡性腫瘤宮頸癌658例，卵巢癌246例。年齡30～71歲，平均年齡（48.12±5.23）歲。納入標準[4]：（1）所有患者經病理學均確診為宮頸癌或卵巢癌；（2）均接受手術治療；（3）自愿參加本次研究；（4）均進行梅毒螺旋體排查。排除標準：（1）合并其他系統嚴重疾病；……