卡介菌多糖核酸聯合膦甲酸鈉治療復發性生殖器皰疹的療效觀察

蔣曉秋 趙輝 徐莉峰 倪婷婷 李茂宇 王佩蓉

【摘要】目的：探討卡介菌多糖核酸聯合膦甲酸鈉治療復發性生殖器皰疹的療效。方法：選取我院收治的118例復發性生殖器皰疹患者，將其隨機分為觀察組以及對照組，每組59例，對照組予以膦甲酸鈉靜脈滴注，觀察組在此基礎上肌肉注射卡介菌多糖核酸制劑進行治療，比較兩組治療效果。結果：治療前兩組患者的CD4+、CD8+、CD4+/CD8+指標以及SDS、SAS評分比較無明顯差異，治療后均較治療前明顯改善，且觀察組改善更明顯；觀察組治療后3、6個月的平均復發頻率以及皮損愈合時間均明顯低于治療前，生活質量評分較治療前明顯改善，且治療后3個月與6個月相關指標比較有統計學差異，P<0.05；觀察組的治療有效率為91.53%（54/59），對照組為71.19%（42/59），組間比較有顯著性差異（χ2=6.197，P<0.05）。結論：卡介菌多糖核酸聯合膦甲酸鈉治療復發性生殖器皰疹能夠改善患者的免疫狀態，提高治療效果，降低復發率，且不良反應較小，值得推廣應用。

【關鍵詞】卡介菌多糖核酸；膦甲酸鈉；復發性生殖器皰疹

Effect of BCG polysaccharide nucleic acid joint phosphine formic acid sodium in the treatment of recurrent genital herpesJIANG Xiaoqiu1， ZHAO Hui1， XU Lifeng1， NI Tingting2， LI Maoyu2， WANG Peirong3. 1.Department of Gynecology， Changxing Zhizhou Hospital， Huzhou 313100， Zhejiang， China； 2.Department of Gynecology， Huzhou Maternal and Children Health Care Center， Huzhou 313000， Zhejiang， China； 3.Department of Psychiatry， Xianlin Branch， Zhejiang Provincial Tongde Hospital， Hangzhou 311122， Zhejiang， China

【Abstract】Objectives： To study the effect of BCG polysaccharide nucleic acid joint phosphine formic acid sodium in the treatment of recurrent genital herpes. Methods： 118 patients with recurrent genital herpes in our hospital were randomly divided into observation group and control group， with 59 cases in each group. Control group received phosphine formic acid sodium for intravenous drip treatment and observation group received BCG polysaccharide nucleic acid joint phosphine formic acid sodium for intramuscular injection. Therapeutic effects of two groups were compared. Results： CD4+， CD8+， CD4+ / CD8+ indexes and SDS， SAS score of two groups before treatment had no obvious difference. After treatment the indexes of both groups obviously improved， more significant in observation group. 3， 6 months after treatment， the recurrence rate and skin lesion healing time of observation group were significantly lower than these before treatment. The score of life quality was obviously improved. 3， 6 month after treatment， related indicators in observation group were significantly lower than these before treatment， P< 0.05. The treatment effective rate was 91.53% （54/59） in observation group and 71.19% in control group， with statistically significant difference （χ2 = 6.197， P< 0.05）. Conclusion： BCG polysaccharide nucleic acid joint phosphine formic acid sodium in the treatment of patients with recurrent genital herpes can improve immune status， improve the treatment effect， reduce the recurrence rate， and has less adverse reactions， which is worthy of popularization and application.

【Key words】BCG polysaccharide nucleic acid； Phosphine formic acid sodium； Recurrent genital herpes

【中圖分類號】R752.1【文獻標志碼】A

生殖器皰疹的主要發病原因是由于單純皰疹病毒（HSV-2）感染所導致的，其發病率以及復發率均較高，對人類的健康產生了十分嚴重的危害。感染后患者一般會終生攜帶病原體[1]，病毒主要存在于女性的宮頸、陰道、外陰以及男性的陰莖和尿道中，在性交過程中由于生殖器的表面黏膜受到磨擦作用而導致病毒出現擴散，誘發表皮損傷而發病。大多數病毒會潛伏在骶周圍神經節中，因神經細胞缺乏病毒繁殖所需要的特異性轉錄酶，所以病毒會長期在神經細胞中保持靜止不變[2]，當機體受到外界因素的刺激作用后，神經細胞會重新激活此酶，引起病毒繁殖，導致疾病復發。……