Gprotein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis

Jin-ling SHU,Feng ZHANG,Ling-ling ZHANG,Wei WEI

(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine,Hefei 230032,China）

T1-27

Gprotein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis

Jin-ling SHU,Feng ZHANG,Ling-ling ZHANG,Wei WEI

(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine,Hefei 230032,China）

Gprotein coupled receptors(GPCRs)are transmembrane receptor proteins,which allow signals to transfer across membrane.GPCRs include a large number of receptors,different receptors mediated different signaling pathways of GPCRs-adenylyl cyclase(AC)-cyclic adenosine 3′,5′-monophosphate(cAMP),including β2 adrenergic receptors(β2-ARs)-AC-cAMP signaling pathways,E-prostanoid2/4(EP2/4)-AC-cAMP signaling pathways.Regulatory proteins,such as Gprotein coupled receptor kinases(GRKs)and β-arrestins,play important modulatory roles in GPCRs signaling pathway.GPCRs signaling pathway and regulatory proteins implicate the pathogenesis process of inflammatory and immune response.Rheumatoid arthritis(RA)is an autoimmune disease characterized by synovitis and accompanied with inflammatory and abnormal immune response.This article review the advances on GPCRs signaling pathway implicating in the inflammatory and immune response of RA.

GPCRs;signaling pathway;regulatory proteins;rheumatoid arthritis

The project supported by National Natural Science Foundation of China(81330081,81473223 and 81673444);and Anhui Province Postdoctoral Science Foundation(2016B134)

Ling-ling ZHANG,Tel:13856001266,E-mail：llzhang@ahmu.edu.cn;Wei WEI,Tel:13605510563,E-mail：wwei@ahmu.edu.cn