Protective role of FoxO transcription factors against oxidative stress-induced chondrocyte dysfunction:a new therapeutic target for osteoarthritis

Ri-kang WANG

(1.National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine,Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,China;2.Shenzhen Key Laboratory for Anti-ageing and Regenerative Medicine,Department of Medical Cell Biology and Genetics,Health Science Center,Shenzhen University,Shenzhen 518060,China)

T1-34

Protective role of FoxO transcription factors against oxidative stress-induced chondrocyte dysfunction:a new therapeutic target for osteoarthritis

Ri-kang WANG1,2

(1.National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine,Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,China;2.Shenzhen Key Laboratory for Anti-ageing and Regenerative Medicine,Department of Medical Cell Biology and Genetics,Health Science Center,Shenzhen University,Shenzhen 518060,China)

Chondrocyte dysfunction has been demonstrated to be a major inducer of osteoarthritis(OA).The pathological mechanism of chondrocyte dysfunction is definitely multifactoral,but oxidative stressis regarded as one of the leading causes of apoptosis,autophagy,senescence,and mitochondrial dysfunctionin chondrocytes.Strategies for arresting oxidative stress-induced chondrocyte dysfunction have been considered as potential therapeutic targets for OA.Recently,fork head box O(FoxO)transcription factors have been determined to play a protective role in chondrocytes through the regulation of autophagy and defense against oxidative stress;they also regulate growth,maturation,and matrix synthesis.To explore FoxO′s potential role in the treatment of OA,we first discussed the recent advances in the field of oxidative stress-induced chondrocyte dysfunction and then emphasized the protective role of fox otranscription factors as a potential molecular target for the treatment of OA.Understanding the function of fox otranscription factors will be important in designing next-generation therapies to prevent or reverse the development of OA.

fox otranscription factors;oxidative stress;chondrocyte dysfunction;osteoarthritis

The project supported by National Natural Science Foundation of China(81560662);and China Postdoctoral Science Foundation(2017M610543)

Ri-kang WANG,E-mail:wrk168ok@163.com