Specific role of synovial macrophages in rheumatoid arthritis

Xue-Zhi YANG,Yan CHANG,Wei WEI

(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine,Hefei 230032,China)

T3-17

Specific role of synovial macrophages in rheumatoid arthritis

Xue-Zhi YANG,Yan CHANG,Wei WEI

(Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine,Hefei 230032,China)

Rheumatoid arthritis(RA)is an autoimmune disease,which is characterized by synovial inflammation.Hyperplasia sublining macrophages found in synovium is an early hallmark of RA and effective treatment results in their diminution.However,the origin of these sublining macrophages in synovium(including infiltrated macrophages and tissue-resident macrophages)are still unknown both in animal models of arthritis and RA patients,let alone the differences and feature of these macro?phages.In rheumatic synovium,macrophages are submitted to a large variety of micro-environmental signals which influence the phenotypic polarization and activation of macrophages.Understanding the mechanisms and functional consequences of the heterogeneous macrophages will contribute to confirm their potential role in synovial inflammation development.Furthermore,research on macrophage plasticity to soft-control their phenotypic polarization could lead to novel therapeutic approaches.

synovial macrophage;polarization;heterogeneity;apoptosis；rheumatoid arthritis

The project supported by National Natural Science Foundation of China(31200675,81573443,81330081 and 81673444);Specialized Research Fund forthe DoctoralProgram ofHigherEducation(20123420110003);and Scientific Research of BSKY from Anhui Medical University(XJ201215)

Wei WEI,Tel:13605510563,E-mail:wwei@ahmu.edu.cn