2017年10期
刊物介紹
本刊為專業(yè)學(xué)術(shù)性刊物。主要刊登實(shí)驗(yàn)藥理學(xué)與實(shí)驗(yàn)毒理學(xué)方面的研究論著、簡(jiǎn)報(bào)、短訊、專題述評(píng)和短篇綜述。讀者對(duì)象為從事藥理學(xué)、毒理學(xué)、藥學(xué)、醫(yī)學(xué)和生物基礎(chǔ)科學(xué)研究的科技工作者。
中國(guó)藥理學(xué)與毒理學(xué)雜志
PLENARY LECTURES
INVITED LECTURES
- Direction of new drug research:soft regulation of inflammatory immune responses
- Targeting Gprotein-coupled receptors for the treatment of autoimmune diseases
- Arrestin mediated GPCR biased signaling and its application in new drug discovery
- Identification of a novel target for cancer and anti-fibrotic therapy
- Rational design of GRK2 inhibitors for the treatment of heart failure
- Drugs and natural products:from plants and livestock to human therapeutics
- Berberine is a new mechanism drug against energy metabolic disorder
- A systematic approach to select and evaluate natural products as precipitants of pharmacokinetic natural product-drug interactions
- Collateral disease research and translational medicine
- New approaches for identifying biologically active components of botanical natural products
- Reverse pharmacokinetics guided target identification and mechanistic understanding of Chinese medicines
T1 MOLECULAR PHARMACOLOGY AND DRUG DISCOVERY
- Identification and optimization of a potent and highly selective D3 dopamine receptor agonist
- Abuse-related effects of synthetic cathinones:importance of DAT/SERT relationships
- Cell-type specific examination of central amygdala dopamine receptor 2 expressing neurons as a translational target for pharmacological enhancement of extinction
- Diazepam reduces synaptic GABA type areceptor availability via multiple trafficking mechanisms
- A novel GPCR mediates pancreatic cancer associated fibroblast-cancer cell interaction
- Targeting androgen receptor and trail:a novel treatment paradigm for breast cancer
- Studies on the mechanism of SIRT1/AMPK signaling pathway between hepatocytes and hepatic stellate cells
- Research progress of TREM2 in Alzheimer disease
- TRPA1 channel mediates organophosphate-induced delayed neuropathy
- Cytoplasmic translocation of Cx32 mediates cisplatin resistance in ovarian cancer cells
- Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo
- Gecko crude peptides inhibit migration and lymphangiogenesis by down regulating the expression of VEGF-C in human hepatocellular carcinoma cells and human lymphatic endothelial cells
- Regulatory effects of GRK2 on GPCRs and possible use as a drug target
- Selective targeting p53WTlung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA
- Inhibition of cervical cancer cell proliferation and cervical tumorigenicity caused by farnesoid X receptor activation or over-expression is related to CDKN2A-p14ARF-MDM2-p53 pathway
- Inhibition of miR-873 provides therapeutic benefit in lipopolysaccharide-induced Parkinson disease animal model
- PD-1/PD-L1 checkpoint blockade in immune-antitumortherapy:advances and perspectives
- Regulation of nitric oxide donor JS-K on tumor energy metabolism in H22 tumor-bearing mice
- DL0410,a candidate for anti-Alzheimer disease with multiple targets in multiple pathways
- Saikosaponin-b regulates the proliferation and apoptosis of HepG2 cells by targeting the MACC1/c-Met/Akt signaling pathway
- Insulin-like growth factor-binding protein-3 inhibits IGF-1-induced proliferation of human hepatocellular carcinoma cells
- Restoration of E-cadherin by compound 8J protects against cisplatin-induced acute kidney injury by attenuating inflammation and programmed cell death
- Protective role of brain CYP2J in diverse Parkinson disease animal models
- Combination of carboxyamidotriazole and 1-Methyl-L-tryptophan has synergistic inhibtory effects on programmed death 1 expression
- A novel anti-inflammatory and immunomodulatory drug CP-25 alleviated collagen induced arthritis by down-regulating BAFF-NF-κ B signaling pathway
- Development of an XBP1 agonist,HLJ2,as a potential therapeutic agent for ulcerative colitis
- Gprotein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis
- Non-junctional Cx32 mediates anti-apoptotic and pro-tumor effects via epidermal growth factor receptor in human cervical cancer cells
- Drug repurposing of histone deacetylase inhibitors that alleviate neutrophilic inflammation in acute lung injury and idiopathic pulmonary fibrosis viainhibiting leukotriene a4 hydrolase and blocking LTB4 biosynthesis
- Effects of methionine enkephalin on immune enhancement by reducing myeloid derived suppressor cells and reprogramming liver metabolism in colon cancer mice
- MicroRNA-10a promotes granulosa cells tumor development
- Estrogen weakens muscle endurance via estrogen receptor-MAPK mediated orosomucoid suppression
- Cellular and molecular perspectives of macrophage in rheumatoid arthritis
- PID1,a new tumor-promoting gene in insulin resistance mediated acceleration of hepatocellular carcinoma development and progression
- Effects of immunoglobulin D on expression of IgD receptor and protein tyrosine kinase signaling in human CD4+T cells
- Improved anti-tumor efficacy and pharmacokinetics of bufalin via PEGylated liposomes
- Involvement of PPARs in the regulation of brain CYP2D by growth hormone
- Discovery of a small-molecule bromodomain-containing protein 4 inhibitor that induces AMP-activated protein kinase-modulated autophagy-associated cell death in breast cancer
- A small-molecule activator of ULK1 that induces cytoprotective autophagy for Parkinson disease treatment
- Functionally diverse ligands modulate different activation states of the formyl peptide receptor 2,a Gprotein-coupled receptor
- CP-25 inhibits the functions of activated human B cells through regulating BAFF-TRAF2-NF-κ B and TNF-alpha-TRAF2-NF-κ B signaling
- SOD mimicAEOL-10150 improve lifespan and delay brain aging via inhibition of senescence-associated secretory phenotype in SAMR1 strain
- Protective action of aspirin and its against endothelial Nlrp3 inflammasome activation in response to LPS stimuli
T2 TRADITIONAL CHINESE MEDICINES AND NATURAL PRODUCTS
- Bile salt derivatives with novel skeleton from sea lamprey function as putative pheromone
- Progress in preventive effects of cordyceps sinensis on ischemic brain
- Ginsenoside metabolite compound K alleviate collegen-induced arthritis through impairing dendritic cells function
- Effects of LW-AFC,a new formula derived from Liuwei Dihuang decoction,on intestinal microbiome in senescence-accelerated mouse prone 8 strain,a mouse model of Alzheimer disease
- Xiaochaihutang attenuates liver fibrosis in rats through activation of Nrf2 pathway
- Protective effects of imperatorin against cerebral ischemia/reperfusion-induced oxidative stress through Nrf2 signaling pathway in rats
- LW-AFC and its active components ameliorate corticosterone-induced long-term potentiation impairment in mice
- Effect of Shenfu injection on microcirculation effect index in early-and middle-stage of cardiogenic shock rats
- Research progress of tonic Chinese medicine on the immune system
- Protective effect and its mechanism of codonopsis pilosula polysaccharide on memory consolidation disorder induced by cycloheximide in mice
- Lychee seed saponins improve cognitive function and ameliorate hippocampal neuronal injury in Alzheimer disease rat model induced by Aβ 25-35through AKT/GSK3β pathway
- Protective estrogen-like properties and mechanism of quercetin in rat cerebral cortex neurons
- Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2/Glo-1 mediated by phosphorylation regulation
- Herb-herb interaction in traditional Chinese medicine：a review of pharmacokinetics-based interaction in Herb-Pairs
- Mechanistic study on the pharmacokinetic process of salidroside in hypoxic rats
- Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer
- miRNA-124 in immune system and immune disorders
- Nicotine protects against ulcerative colitis through regulating microRNA-124 and STAT3
- Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model
- Neuroprotective effect of quercetin on beta-amyloid-induced PC12 cells injury and potential related mechanism
- LW-AFC,a new formula derived from Liuwei Dihuang decoction,ameliorates behavioral and pathological deterioration via modulating the neuroendocrine-immune abnormalities in PrP-hAβ PPswe/PS1ΔE9transgenic mice
- Comprehensive regulation of traditional Chinese medicine on proliferation and differentiation of neural stem cells
- Beneficial effect of berberine on atherosclerosis based on attenuating vascular inflammation and calcification
- Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α -Synuclein and Huntingtin in PC-12 cells
- Dimethyl sulfide,a metabolite of the marine microorganism,protects SH-SY5Y cells against 6-hydroxydopamine and MPP+-induced apoptosis
- Review for treatment and signaling pathway regulation of kidney-tonifying traditional Chinese medicine on osteoporosis
- Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomeraseⅠ and topoisomeraseⅡ
- Ganoderma triterpenes slow cyst growth in polycystic kidney disease
- Inhibitory effect of baicalein on mice tremor induced by oxotremorine and mechanisms
- Hepato-protective effect of thymoquinone against acetaminophen induced liver injury is associated with regulation of JNK and AMPK signaling pathway
- 20C，a new bibenzyl compound,plays a significant role in rotenone-induced oxidative insult
- Application of an ultra performance liquid chromatography-tandem mass spectrometry method to the pharmacokinetics study of paeoniflorin-6′-O-benzene sulfonate and its active paeoniflorin metabolite in rat plasma
- Wudang cherry ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice
- Enhanced anti-cancer effect of gambogic acid by gold nanorod-based delivery
- Salvianolic acid A ameliorates AGEs-induced glomerular endothelial dysfunction and protects against diabetic nephropathy
- Advances in research on chemical constituents,pharmacological actions and processing of atractylodes macrocephala
- Neuroprotective effect of LSS on Aβ 1-42-induced BV-2 microglial cells through the inhibition of neuroinflammation
- Effect of Guizhi Fuling capsule and its extracts on human breast cancer cells proliferation
T3 OTHERS
- Effect of differential rearing environments on nicotine-stimulated locomotor activity and nicotinic acetylcholine receptor subtypes
- Cell-based therapy for management of osteoarthritis
- Neurotransmitter systems in mouse airways
- Pharmacological characterizationof synthetic cannabinoid MAM-2201:radioligand binding and abuse-related effects
- Function of IgD on lymphocyte activation and effect of hIgD-Fc-Ig fusion protein on human PBMC proliferation
- MLKL forms cation channels
- Differentially expressed genes of HepG2 cells treated with gecko polypeptide mixture
- Glucuronidation is the dominating in-vivo metabolism pathway of herbacetin:elucidation of herbacetin pharmacokinetics after intravenous and oral administration in rats
- Topically applied hypericin exhibits skin penetrability on nude mice
- Biphasic modulation of chemerin peptide-induced calcium flux and ERK phosphorylation by amyloid beta peptide
- Pharmacokinetics and pharmacodynamics of cisatracurium in children undergoing cleft lip or cleft palate repair surgery
- Assembly of a highly stable luminescent Zn5 cluster and application to bio-imaging
- Analysis of the key networks,metabolic pathways,and regulation substances of hypoxia based on the omics and zebrafish model
- Gap junctions enhance the antiproliferative effect by transfer of microRNAs in glioma cells
- Reassessment subacute MPTP-treated mice model of Parkinson disease
- Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+/calmodulin-dependent protein kinaseⅡ
- Specific role of synovial macrophages in rheumatoid arthritis
- Connexin 40-formed GJIC increases the phototoxicity of photodynamic therapy through ROS-and calcium-mediated pathways
- Inhibitory effect of compound NS5806 on cardiac transient outward potassium channel dependents on interaction between auxiliary subunits
- Involvement of cysteinyl leukotriene signaling in microglial morphological changes and CASP1 expression in vitro
- Meta-analysis of serum copper and heart failure