虎奶菇提純物聯合布地奈德對小兒支氣管哮喘發作期呼吸力學及細胞免疫功能的影響

李偉豪+謝澤榮+黃桂磐

【摘要】 目的：觀察虎奶菇提純物聯合布地奈德對小兒支氣管哮喘發作期呼吸力學及細胞免疫功能的影響，探討虎奶菇提純物聯合布地奈德在小兒支氣管哮喘發作期中的臨床療效。方法：選擇2014年2月-2016年8月本院兒科門診部支氣管哮喘發作期的患兒180例，按照隨機數字表法分為A觀察組、B觀察組和對照組，各60例，對照組給予對癥治療，A觀察組在對照組治療的基礎上再給予布地奈德治療，B觀察組在對照組治療的基礎上再給予虎奶菇提純物聯合布地奈德治療，比較分析三組療效、呼吸力學參數及細胞免疫功能的改變。結果：治療后，A觀察組、B觀察組和對照組總有效率分別為81.7%、96.7%和71.7%，B觀察組的總有效率優于A觀察組和對照組，A觀察組的總有效率優于對照組，差異均有統計學意義（P<0.05）；B觀察組的動脈血氧分壓（PaO2）、動脈血二氧化碳分壓（PaCO2）、動脈血氧飽和度（SaO2）、動脈血氣指標計算肺血分流率（Qs/Qt）、氣道峰壓（PIP）、氣道阻力（Raw）、呼吸做功（WOB）和動態肺順應性（Cdyn）改變均優于A觀察組和對照組，差異均有統計學意義（P<0.05）；A觀察組PaO2、PaCO2、SaO2、Qs/Qt、PIP、Raw、WOB和Cdyn改變均優于對照組，差異均有統計學意義（P<0.05）；B觀察組的外周血T淋巴細胞亞群CD4+、CD3+和CD4+/CD8+的百分比數值較A觀察組和對照組均顯著降低，B觀察組的CD8+水平較A觀察組和對照組均顯著升高，差異均有統計學意義（P<0.05）；A觀察組的外周血T淋巴細胞亞群CD4+、CD3+和CD4+/CD8+的百分比數值較對照組均顯著降低，A觀察組的CD8+水平較對照組顯著升高，差異均有統計學意義（P<0.05）。結論：虎奶菇提純物聯合布地奈德治療兒童支氣管哮喘發作期，能明顯改善細胞免疫功能，提高肺的順應性和肺氧合率，改善體內缺氧狀態，可以顯著地緩解哮喘癥狀，值得臨床推廣。

【關鍵詞】 兒童； 哮喘； 虎奶菇； 布地奈德； 呼吸力學； 免疫功能

Effects of Pleurotus Tuber Extract and Budesonide on Respiratory Mechanics and Cellular Immune Function in Children with Bronchial Asthma/LI Wei-hao，XIE Ze-rong，HUANG Gui-pan.//Medical Innovation of China，2017，14（17）：005-009

【Abstract】 Objective：To observe the effect of Pleurotus Tuber Extract combined with Budesonide on respiratory mechanics and cellular immune function in children with bronchial asthma，and to explore the clinical effect of Pleurotus Tuber Extract combined with Budesonide in children bronchial asthma.Method：180 cases of children with bronchial asthma who were selected from February 2014 to August 2016 in our hospital pediatric outpatient department were randomly divided into A observation group，B observation group and the control group，60 cases in each group，the control group was given symptomatic treatment，A observation group on the basis of in the control group was given Budesonide，B observation group on the basis of the control group was given Pleurotus Tuber Extract combined with Budesonide.The efficacy，respiratory mechanics parameters and changes in cellular immune function of three groups were compared.Result：After treatment，the total effective rates of A observation group，B observation group and the control group were 81.7%，96.7% and 71.7%，and B observation group was better compared with A observation group and the control group，A observation group was better than that of the control group，the differences were statistically significant（P<0.05）.The changes of arterial oxygen（PaO2），arterial carbon dioxide tension（PaCO2），arterial oxygen saturation（SaO2），arterial blood gas index calculation pulmonary shunt fraction（Qs/Qt），peak airway pressure（PIP），airway resistance（Raw），respiratory work（WOB） and dynamic lung compliance（Cdyn） in B observation group were better than those of A observation group and the control group，the differences were statistically significant（P<0.05）.The changes of PaO2，PaCO2，SaO2，Qs/Qt，PIP，Raw，WOB and Cdyn in the observation group that were better than those in the control group，the differences were statistically significant（P<0.05）.The percentage of CD4+，CD3+ and CD4+/CD8+ in the peripheral blood T lymphocyte subsets of B observation group was significantly lower than those of A observation group and the control group，the level of CD8+ in B observation group was significantly higher than that in A observation group and the control group（P<0.05）.The percentage of CD4+，CD3+ and CD4+/CD8+ in the peripheral blood T lymphocyte subsets of A observation group were significantly lower than those of the control group，and the level of CD8+ in A observation group was significantly higher than that in the control group （P<0.05）.Conclusion：Pleurotus Tuber Extract combined with Budesonide in the treatment of children with bronchial asthma attack，can significantly improve the childrens cellular immune function，improve lung compliance and lung oxygenation rate，improve the body hypoxia，can significantly alleviate the suffering Childrens asthma symptoms，it is worthy of clinical promotion.

【摘要】 目的：觀察虎奶菇提純物聯合布地奈德對小兒支氣管哮喘發作期呼吸力學及細胞免疫功能的影響，探討虎奶菇提純物聯合布地奈德在小兒支氣管哮喘發作期中的臨床療效。方法：選擇2014年2月-2016年8月本院兒科門診部支氣管哮喘發作期的患兒180例，按照隨機數字表法分為A觀察組、B觀察組和對照組，各60例，對照組給予對癥治療，A觀察組在對照組治療的基礎上再給予布地奈德治療，B觀察組在對照組治療的基礎上再給予虎奶菇提純物聯合布地奈德治療，比較分析三組療效、呼吸力學參數及細胞免疫功能的改變。結果：治療后，A觀察組、B觀察組和對照組總有效率分別為81.7%、96.7%和71.7%，B觀察組的總有效率優于A觀察組和對照組，A觀察組的總有效率優于對照組，差異均有統計學意義（P<0.05）；B觀察組的動脈血氧分壓（PaO2）、動脈血二氧化碳分壓（PaCO2）、動脈血氧飽和度（SaO2）、動脈血氣指標計算肺血分流率（Qs/Qt）、氣道峰壓（PIP）、氣道阻力（Raw）、呼吸做功（WOB）和動態肺順應性（Cdyn）改變均優于A觀察組和對照組，差異均有統計學意義（P<0.05）；A觀察組PaO2、PaCO2、SaO2、Qs/Qt、PIP、Raw、WOB和Cdyn改變均優于對照組，差異均有統計學意義（P<0.05）；B觀察組的外周血T淋巴細胞亞群CD4+、CD3+和CD4+/CD8+的百分比數值較A觀察組和對照組均顯著降低，B觀察組的CD8+水平較A觀察組和對照組均顯著升高，差異均有統計學意義（P<0.05）；A觀察組的外周血T淋巴細胞亞群CD4+、CD3+和CD4+/CD8+的百分比數值較對照組均顯著降低，A觀察組的CD8+水平較對照組顯著升高，差異均有統計學意義（P<0.05）。結論：虎奶菇提純物聯合布地奈德治療兒童支氣管哮喘發作期，能明顯改善細胞免疫功能，提高肺的順應性和肺氧合率，改善體內缺氧狀態，可以顯著地緩解哮喘癥狀，值得臨床推廣。

【關鍵詞】 兒童； 哮喘； 虎奶菇； 布地奈德； 呼吸力學； 免疫功能

Effects of Pleurotus Tuber Extract and Budesonide on Respiratory Mechanics and Cellular Immune Function in Children with Bronchial Asthma/LI Wei-hao，XIE Ze-rong，HUANG Gui-pan.//Medical Innovation of China，2017，14（17）：005-009

【Abstract】 Objective：To observe the effect of Pleurotus Tuber Extract combined with Budesonide on respiratory mechanics and cellular immune function in children with bronchial asthma，and to explore the clinical effect of Pleurotus Tuber Extract combined with Budesonide in children bronchial asthma.Method：180 cases of children with bronchial asthma who were selected from February 2014 to August 2016 in our hospital pediatric outpatient department were randomly divided into A observation group，B observation group and the control group，60 cases in each group，the control group was given symptomatic treatment，A observation group on the basis of in the control group was given Budesonide，B observation group on the basis of the control group was given Pleurotus Tuber Extract combined with Budesonide.The efficacy，respiratory mechanics parameters and changes in cellular immune function of three groups were compared.Result：After treatment，the total effective rates of A observation group，B observation group and the control group were 81.7%，96.7% and 71.7%，and B observation group was better compared with A observation group and the control group，A observation group was better than that of the control group，the differences were statistically significant（P<0.05）.The changes of arterial oxygen（PaO2），arterial carbon dioxide tension（PaCO2），arterial oxygen saturation（SaO2），arterial blood gas index calculation pulmonary shunt fraction（Qs/Qt），peak airway pressure（PIP），airway resistance（Raw），respiratory work（WOB） and dynamic lung compliance（Cdyn） in B observation group were better than those of A observation group and the control group，the differences were statistically significant（P<0.05）.The changes of PaO2，PaCO2，SaO2，Qs/Qt，PIP，Raw，WOB and Cdyn in the observation group that were better than those in the control group，the differences were statistically significant（P<0.05）.The percentage of CD4+，CD3+ and CD4+/CD8+ in the peripheral blood T lymphocyte subsets of B observation group was significantly lower than those of A observation group and the control group，the level of CD8+ in B observation group was significantly higher than that in A observation group and the control group（P<0.05）.The percentage of CD4+，CD3+ and CD4+/CD8+ in the peripheral blood T lymphocyte subsets of A observation group were significantly lower than those of the control group，and the level of CD8+ in A observation group was significantly higher than that in the control group （P<0.05）.Conclusion：Pleurotus Tuber Extract combined with Budesonide in the treatment of children with bronchial asthma attack，can significantly improve the childrens cellular immune function，improve lung compliance and lung oxygenation rate，improve the body hypoxia，can significantly alleviate the suffering Childrens asthma symptoms，it is worthy of clinical promotion.

【摘要】 目的：觀察虎奶菇提純物聯合布地奈德對小兒支氣管哮喘發作期呼吸力學及細胞免疫功能的影響，探討虎奶菇提純物聯合布地奈德在小兒支氣管哮喘發作期中的臨床療效。方法：選擇2014年2月-2016年8月本院兒科門診部支氣管哮喘發作期的患兒180例，按照隨機數字表法分為A觀察組、B觀察組和對照組，各60例，對照組給予對癥治療，A觀察組在對照組治療的基礎上再給予布地奈德治療，B觀察組在對照組治療的基礎上再給予虎奶菇提純物聯合布地奈德治療，比較分析三組療效、呼吸力學參數及細胞免疫功能的改變。結果：治療后，A觀察組、B觀察組和對照組總有效率分別為81.7%、96.7%和71.7%，B觀察組的總有效率優于A觀察組和對照組，A觀察組的總有效率優于對照組，差異均有統計學意義（P<0.05）；B觀察組的動脈血氧分壓（PaO2）、動脈血二氧化碳分壓（PaCO2）、動脈血氧飽和度（SaO2）、動脈血氣指標計算肺血分流率（Qs/Qt）、氣道峰壓（PIP）、氣道阻力（Raw）、呼吸做功（WOB）和動態肺順應性（Cdyn）改變均優于A觀察組和對照組，差異均有統計學意義（P<0.05）；A觀察組PaO2、PaCO2、SaO2、Qs/Qt、PIP、Raw、WOB和Cdyn改變均優于對照組，差異均有統計學意義（P<0.05）；B觀察組的外周血T淋巴細胞亞群CD4+、CD3+和CD4+/CD8+的百分比數值較A觀察組和對照組均顯著降低，B觀察組的CD8+水平較A觀察組和對照組均顯著升高，差異均有統計學意義（P<0.05）；A觀察組的外周血T淋巴細胞亞群CD4+、CD3+和CD4+/CD8+的百分比數值較對照組均顯著降低，A觀察組的CD8+水平較對照組顯著升高，差異均有統計學意義（P<0.05）。結論：虎奶菇提純物聯合布地奈德治療兒童支氣管哮喘發作期，能明顯改善細胞免疫功能，提高肺的順應性和肺氧合率，改善體內缺氧狀態，可以顯著地緩解哮喘癥狀，值得臨床推廣。

【關鍵詞】 兒童； 哮喘； 虎奶菇； 布地奈德； 呼吸力學； 免疫功能

Effects of Pleurotus Tuber Extract and Budesonide on Respiratory Mechanics and Cellular Immune Function in Children with Bronchial Asthma/LI Wei-hao，XIE Ze-rong，HUANG Gui-pan.//Medical Innovation of China，2017，14（17）：005-009

【Abstract】 Objective：To observe the effect of Pleurotus Tuber Extract combined with Budesonide on respiratory mechanics and cellular immune function in children with bronchial asthma，and to explore the clinical effect of Pleurotus Tuber Extract combined with Budesonide in children bronchial asthma.Method：180 cases of children with bronchial asthma who were selected from February 2014 to August 2016 in our hospital pediatric outpatient department were randomly divided into A observation group，B observation group and the control group，60 cases in each group，the control group was given symptomatic treatment，A observation group on the basis of in the control group was given Budesonide，B observation group on the basis of the control group was given Pleurotus Tuber Extract combined with Budesonide.The efficacy，respiratory mechanics parameters and changes in cellular immune function of three groups were compared.Result：After treatment，the total effective rates of A observation group，B observation group and the control group were 81.7%，96.7% and 71.7%，and B observation group was better compared with A observation group and the control group，A observation group was better than that of the control group，the differences were statistically significant（P<0.05）.The changes of arterial oxygen（PaO2），arterial carbon dioxide tension（PaCO2），arterial oxygen saturation（SaO2），arterial blood gas index calculation pulmonary shunt fraction（Qs/Qt），peak airway pressure（PIP），airway resistance（Raw），respiratory work（WOB） and dynamic lung compliance（Cdyn） in B observation group were better than those of A observation group and the control group，the differences were statistically significant（P<0.05）.The changes of PaO2，PaCO2，SaO2，Qs/Qt，PIP，Raw，WOB and Cdyn in the observation group that were better than those in the control group，the differences were statistically significant（P<0.05）.The percentage of CD4+，CD3+ and CD4+/CD8+ in the peripheral blood T lymphocyte subsets of B observation group was significantly lower than those of A observation group and the control group，the level of CD8+ in B observation group was significantly higher than that in A observation group and the control group（P<0.05）.The percentage of CD4+，CD3+ and CD4+/CD8+ in the peripheral blood T lymphocyte subsets of A observation group were significantly lower than those of the control group，and the level of CD8+ in A observation group was significantly higher than that in the control group （P<0.05）.Conclusion：Pleurotus Tuber Extract combined with Budesonide in the treatment of children with bronchial asthma attack，can significantly improve the childrens cellular immune function，improve lung compliance and lung oxygenation rate，improve the body hypoxia，can significantly alleviate the suffering Childrens asthma symptoms，it is worthy of clinical promotion.

綜上所述，使用虎奶菇提純物聯合布地奈德治療兒童支氣管哮喘發作期，可明顯改善細胞免疫功能，提高肺順應性和肺氧合率，改善體內缺氧狀態，可以顯著地緩解哮喘癥狀，并且虎奶菇提純物溶液味清香，患兒依從性極好，值得臨床推廣。

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（收稿日期：2017-01-16） （本文編輯：程旭然）