依托考昔和鹽酸氨基葡萄糖膠囊聯合運動療法治療膝骨關節炎的效果觀察

馬春芳++楊瓊

[摘要] 目的 探討依托考昔和鹽酸氨基葡萄糖膠囊聯合運動療法治療膝骨關節炎的效果。 方法 回顧性分析浙江省寧波市第六醫院2016年1月～2017年6月收治的219例膝骨關節炎患者臨床資料，依據治療方式不同分為對照組（99例，給予鹽酸氨基葡萄糖膠囊治療）和觀察組（120例，給予托考昔和鹽酸氨基葡萄糖膠囊聯合運動療法治療）。比較兩組治療前后WOMAC評分、美國特種醫院膝關節評分（HSS）、視覺模擬評分（VAS）、5次坐立試驗測評表（FTSST）評分情況及臨床總有效率。 結果 治療前兩組患者疼痛、僵硬、日常活動度評分、HSS評分、VAS評分、FTSST評分比較，差異均無統計學意義（P > 0.05），治療后兩組患者疼痛、僵硬、日常活動度評分、VAS評分、FTSST評分均低于治療前，HSS評分高于治療前，且觀察組上述指標變化更為顯著，差異均有統計學意義（P < 0.05）。觀察組臨床總有效率高于對照組，差異有統計學意義（P < 0.05）。 結論 依托考昔和鹽酸氨基葡萄糖膠囊聯合運動療法治療膝骨關節炎臨床癥狀改善明顯，效果良好，值得臨床推廣應用。

[關鍵詞] 依托考昔；鹽酸氨基葡萄糖膠囊；運動療法；膝骨關節炎

[中圖分類號] R684 [文獻標識碼] A [文章編號] 1673-7210（2017）11（c）-0102-04

The efficacy of Etoricoxib and Glucosamine Hydrochloride Capsules combined with kinesitherapy in the treatment of knee osteoarthritis

MA Chunfang YANG Qiong

Clinical Pharmacology Room， Ningbo No.6 Hospital of Zhejiang Province， Zhejiang Province， Ningbo 315040， China

[Abstract] Objective To explore the efficacy of Etoricoxib and Glucosamine Hydrochloride Capsules combined with kinesitherapy in the treatment of knee osteoarthritis. Methods A total of 219 clinical data of patients with knee osteoarthritis in Ningbo No.6 Hospital of Zhejiang Province from January 2016 to June 2017 were retrospectively analyzed and divided into the control group （99 cases， treated with Glucosamine Hydrochloride Capsules） and the observation group （120 cases， treated with Etoricoxib and Glucosamine Hydrochloride Capsules combined with kinesitherapy） by different treatment methods. The western Ontario and McMaster university osteoarthritis index （WOMAC）， hospital of special surgery （HSS）， visual analogue scale（VAS）， five repetition sit-to-stand test（FTSST） and total effective rate of the two groups were compared. Results There were no statistically significant differences in the pain， stiffness， the scores of daily activity level， HSS， VAS and FTSST in the two groups before treatment （P > 0.05）. After treatment， the pain， stiffness， scores of daily activity level， VAS and FTSST in the two groups were lower than those of before treatment and the score of HSS was higher than that of before treatment， the indicators above in the observation group changed more significantly， with statistically significant differences （P < 0.05）. The total effective rate in the observation group was higher than that of control group， with statistically significant differences（P < 0.05）. Conclusion The clinical symptoms in the patients of knee osteoarthritis treated with Etoricoxib and Glucosamine Hydrochloride Capsules combined with kinesitherapy is improved significantly. The efficacy is good. It is worthy of promotion and application.endprint

[Key words] Etoricoxib； Glucosamine Hydrochloride Capsules； Kinesitherapy； Knee osteoarthritis

膝骨關節炎是以膝關節軟骨的變性、退變和骨質增生等臨床特征為主的退行性骨關節疾病[1-2]。其發生原因比較復雜，主要是由于患者年齡逐漸增大，膝關節軟骨平面出現磨損、破壞，發生骨質增生和囊性改變，進而造成膝關節間隙發生不對稱狹窄，發生膝關節疼痛、畸形及膝關節活動功能障礙[3-4]。目前國內膝骨關節炎發生率達8%，對患者的日常生活和工作造成了嚴重影響[5-6]。選擇有效的膝骨關節炎治療方法成為當前研究的熱點。本研究對219例膝骨關節炎患者的臨床資料進行回顧性分析，擬探討依托考昔和鹽酸氨基葡萄糖膠囊聯合運動療法治療膝骨關節炎的效果。現將……