楊武+劉欽志

【摘要】 目的 探討靜脈麻醉聯(lián)合硬膜外麻醉在結(jié)直腸癌患者手術(shù)麻醉中的效果。方法 40例結(jié)直腸癌患者為研究對象, 采用隨機數(shù)字表法分為對照組與觀察組, 每組20例。對照組行靜脈全身麻醉(全麻), 觀察組行靜脈全麻聯(lián)合硬膜外麻醉。比較兩組麻醉效果、不同時刻心率及動脈壓、術(shù)后麻醉相關(guān)不良反應(yīng)發(fā)生情況。結(jié)果 觀察組患者麻醉效果優(yōu)15例、良5例、差0例, 優(yōu)良率為100.00%(20/20);對照組患者麻醉效果優(yōu)13例、良3例、差4例, 優(yōu)良率為80.00%(16/20);觀察組麻醉優(yōu)良率明顯高于對照組, 差異具有統(tǒng)計學(xué)意義(χ2=4.444, P<0.05)。兩組患者麻醉前(T0)時心率及平均動脈壓對比差異無統(tǒng)計學(xué)意義(P>0.05);切皮后5 min(T1)、切皮后15 min(T2)、術(shù)后10 min(T3)時兩組心率及平均動脈壓均有波動, 對照組波動更為明顯, 與觀察組對比差異具有統(tǒng)計學(xué)意義(P<0.05)。觀察組術(shù)后麻醉相關(guān)不良反應(yīng)發(fā)生率為5.00%(1/20), 明顯低于對照組的30.00%(6/20), 差異具有統(tǒng)計學(xué)意義(χ2=4.329, P<0.05)。結(jié)論 在結(jié)直腸癌根治手術(shù)中應(yīng)用靜脈麻醉聯(lián)合硬膜外麻醉, 效果顯著, 患者生命體征平穩(wěn), 安全性高, 值得推廣。
【關(guān)鍵詞】 結(jié)直腸癌;靜脈麻醉;硬膜外麻醉
DOI:10.14163/j.cnki.11-5547/r.2018.03.006
【Abstract】 Objective To discuss the effect of intravenous anesthesia combined with epidural anesthesia in surgical anesthesia for patients with colorectal cancer. Methods A total of 40 patients with colorectal cancer were divided by random number table method into control group and observation group, with 20 cases in each group. The control group received intravenous general anesthesia, and the observation group received intravenous general anesthesia combined with epidural anesthesia. Comparison were made on anesthesia effect, heart rate and arterial pressure at different times, postoperative anesthesia-related adverse reactions between two groups. Results The observation group had 15 excellent cases, 5 good cases and 0 poor case by anesthesia effect, with excellent-good rate as 100.00% (20/20), while the control group had 13 excellent cases, 3 good cases and 4 poor cases by anesthesia effect, with excellent-good rate as 80.00% (16/20). The observation group had obviously higher anesthesia excellent-good rate than the control group, and the difference was statistically significant (χ2=4.444, P<0.05). Both groups had no statistically significant difference in heart rate and mean arterial pressure before anesthesia (T0) (P>0.05). Both groups had fluctuation at 5 min after skin incision (T1), 15 min after skin incision (T2) and 10 min after operation (T3), and the control group had more obvious fluctuation, and their difference was statistically significant (P<0.05). The observation group had obviously lower incidence of postoperative anesthesia-related adverse reactions as 5.00% (1/20) than 30.00% (6/20) in the control group, and the difference was statistically significant (χ2=4.329, P<0.05). Conclusion Application of intravenous anesthesia and epidural anesthesia shows remarkable effect in radical surgery for colorectal cancer with high safety. Patients have stable vital signs, and it is worth promoting.endprint
【Key words】 Colorectal cancer; Intravenous anesthesia; Epidural anesthesia
結(jié)直腸癌是高發(fā)性消化系統(tǒng)惡性腫瘤, 根治性手術(shù)是當前治療該癥首選方法。靜脈麻醉作為一種全身麻醉手段, 在臨床中得到廣泛運用[1-3]。本研究為進一步探尋結(jié)直腸癌手術(shù)最佳麻醉方案, 對患者應(yīng)用靜脈麻醉聯(lián)合硬膜外麻醉, 報告如下。
1 資料與方法
1. 1 一般資料 選取2015年4月~2017年3月接受結(jié)根治術(shù)治療的40例結(jié)直腸癌患者為研究對象, 經(jīng)倫理委員會審查并批準, 以隨機數(shù)字表法將患者分為觀察組與對照組, 每組20例。對照組中男11例, 女9例, 年齡24~72歲, 平均年齡(49.35±13.26)歲。觀察組中男12例, 女8例, 年齡23~74歲, 平均年齡(49.59±13.21)歲。兩組患者性別、年齡等一般資料比較差異無統(tǒng)計學(xué)意義(P>0.05), 具有可比性。
1. 2 方法 兩組患者術(shù)前30 min均給予苯巴比妥100 mg、阿托品0.5 mg肌內(nèi)注射, 對心率、血壓、呼吸等予以監(jiān)測。開……