EGFL7在乳腺癌中的研究進展

闕海濤 曹斌 秦志剛

摘 要：表皮生長因子樣結構域7是表皮生長因子樣蛋白家族的成員，是一種極為關鍵的血管生成因子和血管發育調節因子，在不同類型細胞中均有表達。EGFL7在早期胚胎的血管中表達較高，主要調節發育過程中的血管生成，促進內皮細胞增殖，形成有功能的血管網，促進組織增長和再生。與其在胚胎期較強的表達相比，在成人體內的表達量微乎其微，異常高表達的EGFL7常在多種惡性腫瘤中出現。目前越來越多的證據表明，EGFL7可調節腫瘤血管生成、促進腫瘤轉移和侵襲。腫瘤組織中EGFL7高表達常常提示腫瘤生長和轉移較為活躍及不良的預后。近年來，一系列研究表明，EGFL7的表達與乳腺癌的發生發展、轉移過程密不可分，且在提示預后方面發揮著關鍵作用。本文就EGFL7在乳腺癌中的研究進展作一綜述，為臨床診斷及治療提供新思路。

關鍵詞：表皮生長因子樣結構域7；乳腺癌；腫瘤診斷

中圖分類號：R737.9 文獻標識碼：A DOI：10.3969/j.issn.1006-1959.2018.23.010

文章編號：1006-1959（2018）23-0032-05

Abstract：Epidermal growth factor-like domain 7 is a member of the epidermal growth factor-like protein family and is a critical angiogenic factor and vascular developmental regulator that is expressed in different cell types. EGFL7 is highly expressed in the blood vessels of early embryos， mainly regulating angiogenesis during development， promoting endothelial cell proliferation， forming a functional vascular network， and promoting tissue growth and regeneration. Compared with its strong expression in the embryonic stage， the expression level in adults is negligible， and abnormally high expression of EGFL7 is often found in many malignant tumors. There is increasing evidence that EGFL7 regulates tumor angiogenesis， promotes tumor metastasis and invasion. High expression of EGFL7 in tumor tissues often indicates a more active and poor prognosis of tumor growth and metastasis. In recent years， a series of studies have shown that the expression of EGFL7 is inseparable from the occurrence and development of breast cancer， and plays a key role in prognosis. This article reviews the research progress of EGFL7 in breast cancer， and provides new ideas for clinical diagnosis and treatment.

Key words：Epidermal growth factor-like domain 7；Breast cancer；Tumor diagnosis

乳腺癌（breast cancer）是一種常見于女性的惡性腫瘤，且在我國的發病率逐年上升，已躍居我國女性癌癥發病率首位，其引發的病死率居第6位且仍呈上升趨勢，嚴重危及女性健康[1，2]；而探索乳腺癌的發病及進展機制，尋找潛在的診斷及治療靶點，愈發成為眾多課題組的研究熱點。表皮生長因子樣結構域7（epidermalgrowthfactor-likedomain 7，EGFL7）又稱為Notch4-lik、VE-stain、Neul，其主要由上皮織分泌，亞細胞定位分析位于胞漿與胞膜[3]，作為關鍵血管生成因子和細胞膜受體的重要調節因子，在許多組織中都有表達。……