貝那普利聯合血栓通膠囊對老年2型糖尿病合并高血壓患者血管內皮功能的影響

陳曼麗 范琳 宮蕊 齊莉莉

[摘要] 目的 探討貝那普利聯合血栓通膠囊對老年2型糖尿病合并高血壓患者血管內皮功能的影響。方法 選取該院老年病科2016年10月—2018年10月選取老年2型糖尿病合并高血壓患者86例作為研究對象，隨機均分為對照組和治療組。對照組給予貝那普利10 mg/d，治療組在對照組基礎上加服血栓通膠囊1粒/次，3次/d。治療8周后，觀察并比較兩組患者血清內皮素1（ET-1）和一氧化氮（NO）等方面的變化。結果 治療后，兩組患者的SBP與DBP水平均有明顯下降，治療組在下降幅度上高于對照組，差異有統計學意義（P<0.05）。治療后ET-1水平均有顯著降低，治療組在降低幅度上高于對照組，差異有統計學意義（P<0.05）。兩組患者治療后NO水平均有顯著升高，治療組在升高幅度上高于對照組，差異有統計學意義（P<0.05）。結論 貝那普利聯合血栓通膠囊治療老年2型糖尿病合并高血壓患者，可以有效地降低患者血壓水平，有助于改善患者血管內皮功能，值得在臨床上推廣使用。

[關鍵詞] 貝那普利;血塞通滴丸;2型糖尿病;高血壓;血管內皮

[中圖分類號] R587.1? ? ? ? ? [文獻標識碼] A? ? ? ? ? [文章編號] 1672-4062（2019）03（a）-0109-02

[Abstract] Objective To investigate the effect of benazepril combined with Xueshuantong Capsule on vascular endothelial function in elderly patients with type 2 diabetes mellitus complicated with hypertension. Methods 86 elderly patients with type 2 diabetes mellitus complicated with hypertension were selected from October 2016 to October 2018 in our hospital. They were randomly divided into control group and treatment group. The control group was given benazepril 10 mg/d， and the treatment group was given Xueshuantong Capsule 1 capsule/time， 3 times/d on the basis of the control group. After 8 weeks of treatment， changes in serum endothelin-1 （ET-1） and nitric oxide （NO） were observed and compared between the two groups. Results After treatment， both SBP and DBP levels were significantly lower in the two groups. The decrease in the treatment group was higher than that in the control group（P<0.05）. After treatment， the level of ET-1 was significantly lower than that of the control group， and the difference was statistically significant（P<0.05）. The levels of NO in the two groups were significantly increased after treatment. The increase in the treatment group was higher than that in the control group， and the difference was statistically significant（P<0.05）. Conclusion Benazepril combined with Xueshuantong Capsule can effectively reduce the blood pressure level of patients with type 2 diabetes mellitus and hypertension. It is helpful to improve the vascular endothelial function of patients and it is worthy of clinical application.

[Key words] Benazepril; Xuesaitong dripping pills; Type 2 diabetes; Hypertension; Vascular endothelium

近年來，有研究指出，糖尿病合并高血壓的患者會出現不同程度的血管內皮功能障礙，且多發生在糖尿病患者微血管及微觀發生病變以前。如患者發生內皮功能異常，那么就促進了高血壓的進程，從而誘發早期動脈粥樣硬化的形成[1]。該文采用貝那普利聯合血塞通滴丸對老年2型糖尿病合并高血壓患者進行治療，并觀察血管內皮功能的變化，現報道如下。

1? 資料與方法

1.1? 一般資料