丁苯酞軟膠囊聯合奧拉西坦注射劑治療腦梗死的預后效果評價

游海洋 肖麗

摘 要 目的：探討丁苯酞軟膠囊聯合奧拉西坦注射劑治療急性腦梗死的預后效果。方法：納入2017年8月至2019年7月江西省上饒市廣信區人民醫院神經內科收治的急性腦梗死患者80例，根據隨機數字表法分為觀察組和對照組各40例。對照組給予奧拉西坦注射劑4 g+0.9%氯化鈉注射液100 ml靜脈滴注，1次/d；觀察組在對照組基礎上聯合丁苯酚軟膠囊口服，200 mg/次，3次/d。治療14 d后，比較神經功能缺損（NIHSS）評分、Barthel指數（BI）評分、肢體運動功能（FMA）評分和認知功能評分變化情況，觀察臨床療效。結果：觀察組總有效率為97.50%，高于對照組的75.00%（P<0.05）；且干預后NIHSS評分較低，BI評分、FMA評分較高，同干預前以及對照組對比差異有統計學意義（P<0.05）；而干預后蒙特利爾認知評估量表（MOCA）評分和韋氏記憶量表（WMS）評分均高于干預前和對照組（P<0.05）。結論：丁苯酞軟膠囊聯合奧拉西坦注射劑治療腦梗死效果較好，可以改善患者的神經功能和認知功能，應用價值較高。

關鍵詞 腦梗死；丁苯酞軟膠囊；奧拉西坦注射劑；預后

中圖分類號：R743.3 文獻標志碼：A 文章編號：1006-1533（2020）12-0035-03

Evaluation of prognostic effect of butylphthalide soft capsules combined with oxiracetam injection in the treatment of cerebral infarction

YOU Haiyang， XIAO Li（Department of Neurology of Peoples Hospital of Guangxin District， Shangrao City， Jiangxi Province 334100， China）

ABSTRACT Objective： To explore the prognostic effect of butylphthalide soft capsules combined with oxiracetam injection in the treatment of acute cerebral infarction. Methods： From August 2017 to July 2019， 80 patients with acute cerebral infarction were enrolled in the Department of Neurology of Peoples Hospital in Guangxin District， Shangrao City， Jiangxi Province， and according to the method of random number table divided into an observation group and a control group with 40 cases each. The control group was given 4 g of oxiracetam + 0.9% 100 ml of sodium chloride injection intravenously， once a day； on the basis of the control group， the observation group was given oral butyl phenol soft capsule， 200 mg/time， 3 times/day. After 14 days of treatment， the changes of neurological deficit（NIHSS） score， Barthel index（BI） score， limb motor function（FMA） score and cognitive function score were compared to observe the clinical efficacy. Results： The total effective rate in the observation group was 97.50%， which was higher than 75.00% in the control group（P<0.05）； after the intervention， in the observation group the NIHSS score was lower， the BI score and the FMA score were higher， and the differences were statistically significant compared with those before the intervention and the control group（P<0.05）； the scores of the Montreal cognitive assessment scale and the Websters memory scale in the observation group after intervention were higher than those before the intervention and in the control group（P<0.05）. Conclusion： Butylphthalide soft capsules combined with oxiracetam injection have a better effect in the treatment of cerebral infarction， can improve patientsneurological and cognitive functions， and have high application value.