乳果糖治療阿片類藥物所致便秘的臨床分析

張建筑

[摘要] 目的 探討乳果糖治療阿片類藥物所致便秘的臨床效果。方法 方便抽取2018年8月—2019年8月在該院接受治療的阿片類藥物所致便秘患者78例為研究對象，根據(jù)其住院先后順序從1～78編號，再按等差數(shù)列首項為1，公差為2的方式將78例患者平均分為兩組，即對照組與實驗組，兩組患者均為39例。對照組采用番瀉葉治療，實驗組采取乳果糖口服液治療，對比兩組患者的治療效果。結(jié)果 實驗組患者治療總有效率94.87%高于對照組76.92%，差異有統(tǒng)計學(xué)意義（χ2=7.245，P<0.05）;治療前，實驗組與對照組患者便秘評分，差異無統(tǒng)計學(xué)意義（P>0.05）;治療后，實驗組患者便秘評分（4.82±1.88）分顯著低于對照組（6.99±1.54）分，差異有統(tǒng)計學(xué)意義（t=6.245，P<0.05）。結(jié)論 乳果糖治療阿片類藥物所致便秘效果顯著，能夠提高治療總有效率，降低患者的便秘評分，值得在臨床上廣泛推廣。

[關(guān)鍵詞] 乳果糖;阿片類藥物;便秘;評分;總有效率;效果

[中圖分類號] R730 ? ? ? ? ?[文獻標識碼] A ? ? ? ? ?[文章編號] 1674-0742（2020）11（a）-0090-03

Clinical Analysis of Lactulose in the Treatment of Constipation Caused by Opioids

ZHANG Jian-zhu

Department of Gastroenterology， Boxing County Hospital of Traditional Chinese Medicine， Binzhou， Shandong Province， 256500 China

[Abstract] Objective To explore the clinical effect of lactulose in the treatment of constipation caused by opioids. Methods A total of 78 patients with constipation caused by opioids who were treated in our hospital from August 2018 to August 2019 were selected as the research objects. They were numbered from 1-78 according to their hospitalization sequence， and the first item in the arithmetic sequence was 1， with a tolerance of 2， 78 patients were equally divided into two groups， namely the control group and the experimental group， with 39 patients in both groups. The control group was treated with senna leaves， and the experimental group was treated with lactulose oral liquid. The treatment effects of the two groups were compared. Results The total effective rate of treatment in the experimental group was 94.87% higher than that in the control group 76.92%， the difference was statistically significant（χ2=7.245，P<0.05）; before treatment， there was no statistically significant difference in constipation score between the experimental group and the control group（P>0.05）; After treatment， the constipation score （4.82±1.88） points of the experimental group was significantly lower than that of the control group （6.99±1.54） points， the difference was statistically significant（t=6.245，P<0.05）. Conclusion Lactulose is effective in treating constipation caused by opioids. It can improve the total effective rate of treatment and reduce the constipation score of patients. It is worthy of being widely promoted in clinical practice.

[Key words] Lactulose; Opioids; Constipation; Score; Total effective rate; Effect

癌癥患者普遍經(jīng)受嚴重的生理疼痛，多數(shù)患者在長期的病痛折磨下容易產(chǎn)生輕生的念頭[1]。目前來看，癌癥是無法根治的，但是能夠通過藥物減輕患者的疼痛感。癌性疼痛對患者的正常生活有很大影響，在癌痛控制過程中，要選擇合適的藥物[2]。阿片類藥物是常用的藥物，能夠緩解患者的生理疼痛感，被廣泛應(yīng)用于中重度癌痛治療中[3]。研究發(fā)現(xiàn)患者長期服用阿片類藥物容易引起便秘，而且便秘概率高達80%以上，藥物劑量越大，患者的便秘程度越嚴重，給患者的正常生活帶來極大影響[4]。還有部分患者無法忍受便秘的疼痛感停用了阿片類藥物，延長了治療周期。臨床發(fā)現(xiàn)給予患者乳果糖口服液能夠緩解患者的便秘癥狀，基于此該次研究方便抽取2018年8月—2019年8月在該院接受治療的阿片類藥物所致便秘患者78例為研究對象，探討乳果糖治療阿片類藥物所致便秘的臨床效果。現(xiàn)報道如下。