葉酸聯合維生素B6治療缺血性腦卒中相關血清指標觀察及療效分析

孫亞男　　孫紅霞　　姜爽　　鄭敏　　朱兆武

[摘要] 目的 探討常規治療與葉酸聯合維生素B6治療缺血性腦卒中療效及對相關血清指標的影響。 方法 采集2020年1—10月我院缺血性腦卒中患者450例，通過隨機數字法分為對照組（常規治療）與研究組（葉酸聯合維生素B6），每組各225例。比較兩組治療前后NIHSS評分及mRS評分、治療效果、生化指標、治療后D-二聚體、TG、LDL-C、TC、Hcy、HDL-C等指標。 結果 兩組治療前NIHSS評分及mRS評分比較，差異無統計學意義（P>0.05）;研究組治療后NIHSS評分[（4.77±2.19）分]與mRS評分[（3.01±0.54）分]均低于對照組，差異有統計學意義（P<0.05）。研究組治療后總有效率（94.7%）高于對照組（80.4%），差異有統計學意義（P<0.05）。兩組治療前各項生化指標水平比較，差異無統計學意義（P>0.05）;研究組治療后D-二聚體（2.11±0.39）μg/L、TG（3.46±0.33）mmol/L、LDL-C（1.39±0.20）mmol/L、TC（1.51±0.31）mmol/L、Hcy（1.31±0.20）μmol/L水平均低于對照組，HDL-C[（1.31±0.20）mmol/L]水平高于對照組，差異有統計學意義（P<0.05）。 結論 在缺血性腦卒中治療中，更推薦采用葉酸聯合維生素B6治療，可減輕神經功能受損程度，改善D-二聚體與Hcy水平，使血脂水平得到有效調整，整體治療效果明確。

[關鍵詞] 常規治療;葉酸;維生素B6;缺血性腦卒中;血清指標

[中圖分類號] R743.1? ? ? ? ? [文獻標識碼] B? ? ? ? ? [文章編號] 1673-9701（2021）20-0058-04

Observation and efficacy analysis on the folic acid combined with Vitamin B6 in the treatment of ischemic stroke related serum index

SUN Ya′nan? ?SUN Hongxia? ?JIANG Shuang? ?ZHENG Min? ?ZHU Zhaowu

No.1 Department of Encephalopathy，Jiamusi Traditional Chinese Medicine Hospital in Heilongjiang Province， Jiamusi 154000， China

[Abstract] Objective To explore the curative effect of conventional treatment and folic acid combined with vitamin B6 in the treatment of ischemic stroke and its effects on related serum indices. Methods From January 2020 to October 2020，a total of 450 patients with ischemic stroke in our hospital were collected. They were divided into a control group of 225 cases （conventional treatment） and a study group of 225 cases （folic acid combined with vitamin B6） by random number method. The NIHSS score and mRS score before and after treatment， curative effect， biochemical indices， D-dimer， TG， LDL-C， TC， Hcy， and HDL-C after treatment of two groups were compared. Results The difference between the NIHSS score and mRS score before treatment between the two groups was small and not statistically significant（P>0.05）; compared with the control group， the NIHSS score （4.77±2.19） points and mRS score （3.01±0.54） points in the study group after treatment were lower， and the difference was large and statistically significant（P<0.05）. Compared with the control group（80.4%）， the total effective rate after treatment in the study group was 94.7%， and the difference was large and statistically significant（P<0.05）. The differences in the levels of various biochemical indicators between the two groups before treatment were small and not statistically significant（P>0.05）; compared with the control group， the D-dimer （2.11±0.39）μg/L， TG（3.46±0.33）mmol/L， LDL-C（1.39±0.20）mmol/L， TC （1.51±0.31）mmol/L，and Hcy （1.31±0.20）μmol/L after treatment were lower， and the level of HDL-C（1.31±0.20）mmol/L was higher. The differences were statistically significant（P<0.05）. Conclusion In the treatment of ischemic stroke， folic acid combined with vitamin B6 therapy is more recommended， which can reduce the degree of neurological impairment，improve the level of D-dimer and Hcy， and effectively adjust the blood lipid level.The overall therapeutic effect is exact.