病毒性腦炎患兒血清神經(jīng)元特異性烯醇化酶檢測的臨床意義

摘 要 目的:探討病毒性腦炎患兒血清神經(jīng)元特異性烯醇化酶(NSE)水平的變化及意義。方法:應(yīng)用酶聯(lián)免疫吸附法(ELISA)對病毒性腦炎患兒急性期和恢復(fù)期血清神經(jīng)元特異性烯醇化酶的水平測定，并與22例健康兒進(jìn)行比較。結(jié)果:病毒性腦炎患兒急性期14.64±3.39μg/L血清神經(jīng)元特異性烯醇化酶濃度明顯升高，較對照組9.67±2.29μg/L有顯著差異，具有統(tǒng)計學(xué)意義(P<0.05)，恢復(fù)期11.40±2.13μg/L與急性期14.64±3.39μg/L比較明顯下降，有顯著性差異(P<0.05)。結(jié)論:病毒性腦炎患兒血清中神經(jīng)元特異性烯醇化酶濃度明顯升高，其水平與疾病的發(fā)生發(fā)展和病情嚴(yán)重程度有關(guān)，可作為判斷病毒性腦炎患兒腦組織損傷的客觀指標(biāo)之一。

關(guān)鍵詞 病毒性腦炎 神經(jīng)元特異性烯醇化酶 血清

doi:10.3969/j.issn.1007-614x.2010.24.178

AbstractObjective:to investigate the changes and clinical significance of serum neuron-specific enolase levels in pediatric patients with viral encephalitis.Methods:The concentration of neuron-specific enolase(NSE) in serum were measured by enzyme linked immunosorbent sorbent assay(ELISA) method when the patients were in acute stage and convalescent period.Twenty-two healthy children served as controls.Results:The serum neuron-specific enolase levels of the patients in acute stage(14.64±3.39)μg/L were significantly higher than those of the control group(9.67±2.29)μg/L，and there were significant difference between viral encephalitis group and the control group(P<0.05).Their levels in convalescent stage(11.40±2.13)μg/L were significantly lower than those of the cases in acute stage(14.64±3.39)μg/L(P<0.05).Conclusion: The serum levels of neuron-specific enolase in the children with viral encephalitis raise significantly， their levels in children connected significantly with the advance and the condition of viral encephalitis. NSE in serum maybe used as an objective standard of degree of brain injury.

KeywordsViral encephalitis;Neuron-specific enolase;Serum