四株益生菌對高脂血癥倉鼠降血脂作用的研究

張澤生，王俊輝，李 健，趙春曉

(天津科技大學食品工程與生物技術學院，天津300457)

四株益生菌對高脂血癥倉鼠降血脂作用的研究

張澤生，王俊輝，李 健，趙春曉

(天津科技大學食品工程與生物技術學院，天津300457)

目的:觀察不同益生菌菌株對實驗性高脂血癥倉鼠脂代謝的影響。方法:利用高脂飼料誘導倉鼠高脂血癥模型，給倉鼠灌胃益生菌菌液，測定血清總膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白膽固醇(HDL-C)的含量及肝臟組織中TC、TG的含量。結果:四株益生菌均可有效降低高脂膳食倉鼠血清TC、TG、非高密度脂蛋白膽固醇(non-HDL-C)含量及動脈粥樣硬化指數(AI)值，提高HDL-C含量，還可以顯著降低肝臟中TC、TG含量。結論:四株益生菌均能有效改善倉鼠血脂代謝，預防和減少動脈粥樣硬化的發生。鼠李糖乳桿菌降低高脂飲食倉鼠血清TC、TG含量的作用最強，嗜酸乳桿菌、鼠李糖乳桿菌升高血清HDL-C含量的作用最強，但嗜酸乳桿菌降低肝臟中TC含量的作用最強。

益生菌，高脂血癥，倉鼠

Abstract:Objective:To observe influence of different probiotic strains on lipid metabolism of experimental hyperlipidemic hamsters.Methods:Healthy male hamsters were fed high-fat diet to create the hyperlipidemic animal model.Probiotic liquid were filled into stomach of hamsters.The content of total cholesterol(TC)，triglyceride(TG)，high-density lipoprotein cholesterol(HDL-C)in serum and total cholesterol，triglyceride in liver were assayed.Results:The TC，TG，non-high density lipoprotein cholesterol(non-HDL-C)and the value of atherosclerosis index(AI)in serum could be decreased significantly in the hyperlipidemic hamsters by four probiotic strains.The HDL-C in serum could be increased.The TC，TG in lipid could also be decreased.Conclusion:Lipid metabolism of hamsters could be improved，and the incidence of atherosclerosis could also be prevented and reduced by four probiotic strains.The ability of Lactobacillus rhamnosus reducing TC，TG in serum was the strongest，the ability of Lactobacillus acidophilus as well as Lactobacillus rhamnosus increasing HDL-C in serum and Lactobacillus acidophilus lowering TC in liver was the strongest.

Key words:probiotic;hyperlipidemia;hamster

隨著現今社會生活水平大幅度的提高，人們的膳食習慣也隨之發生了變化，但同時也帶來了健康隱患，由高血脂引發的多種心腦血管疾病的發病率呈現逐年上升趨勢。FAO/WHO《食品益生菌評價指南》明確規定，食品用益生菌是指“服用一定數量后對人體健康有益的活的微生物”，益生菌的有效性與活菌數量和菌種本身的性能密切相關［1］。益生菌在促進人體健康和預防疾病中發揮著重要的作用，是未來功能性食品發展的重要領域。……