宮腔內人工授精促排卵周期中使用促性腺激素釋放激素激動劑誘導卵泡成熟的效果觀察

連蔚 羅一平 田小燕 梁美燕

【摘要】目的：研究觀察宮腔內人工授精促排卵周期中使用促性腺激素釋放激素激動劑（GnRha）誘導卵泡成熟的效果。方法：從2013年4月至2014年4月，選擇我院入院實施宮腔內授精治療的100例不孕女性進行研究，以數字法隨機分為觀察組以及對照組，每組各50例。對觀察組在促排卵周期中使用GnRha誘導卵泡成熟，對照組使用人絨毛膜促性腺激素（hCG）。觀察對比兩組療效。結果：兩組經過不同方式誘導卵泡成熟，排卵率，未破裂卵泡黃素化綜合征以及臨床妊娠率無較大差異；然而觀察組的卵巢過度刺激綜合征發生率明顯小于對照組。對比結果表明，觀察組與對照組的評分在干預之后均得到明顯調節；但是觀察組的降低程度明顯優于對照組。兩組患者實施不同方式之后，觀察組患者效果顯著優于對照組。兩組在干預之前生活質量的各指標水平比較無顯著差異。在進行干預后兩組指標水平均上升，并且觀察組均大于對照組。差異均有統計學意義（均P<0.05）。結論：宮腔內人工授精促排卵周期中使用GnRha誘導卵泡成熟效果較好，降低了卵巢過度刺激綜合征的發生率。有效提升患者的生活質量，安全性較高。

【關鍵詞】宮腔內；人工授精；促排卵；促性腺激素釋放激素激動劑；卵泡成熟

Curative effect of GnRha induced oocyte maturation in intrauterine insemination cyclesLIAN Wei， LUO Yiping， TIAN Xiaoyan， LIANG Meiyan. Department of Obstetrics and Gynecology， Shunde First Peoples Hospital， Foshan 528300， Guangdong， China

【Abstract】Objectives： To observe the curative effect of GnRha induced oocyte maturation in intrauterine insemination cycles. Methods： 100 couples receiving treatment of intrauterine insemination in our hospital from April 2013 to April 2014 were selected and randomly divided into observation group and control group， with 50 couples in each group. The observation group was treated with GnRha to induce follicular maturation in the cycle of ovulation； the control group used human chorionic gonadotropin （HCG）. Curative effects of the two groups were compared. Results： After different induction of follicular maturation， ovulation rate， syndrome and clinical pregnancy rate of unruptured luteinized follicles in the two groups had no significant difference； however， the incidence of OHSS in observation group was significantly less than that in control group. The observation group and the control group were significantly regulated after the intervention； but the decrease in observation group was significantly better than that in control group. After the implementation of different ways， the effect in the observation group was significantly better than that in control group. There was no significant difference in each index level between the two groups before the intervention. The index levels of the two groups were increased after the intervention， higher in the observation group， with statistically significant differences （all P<0.05）. Conclusion： GnRha induced oocyte maturation in intrauterine insemination cycles can reduce the incidence of ovarian hyperstimulation syndrome and improve the quality of life of patients， with higher safety.

【Key words】Intrauterine； Artificial insemination； Ovulation induction； GnRha； Follicle

【中圖分類號】R711.6【文獻標志碼】A

現如今，在我國的育齡夫婦中，不孕不育的比例高達10%，并且仍然呈現出上升趨勢。宮腔內人工授精指的是使用一種較為經濟、安全并且便于廣泛應用的輔助助孕技術[1-3]。對不孕患者實施促排卵治療成為目前臨床的熱點。人絨毛膜促性腺激素（hCG）對于誘導卵泡成熟具有一定的效果，然而會致使多卵泡發育以及卵巢過度刺激綜合征的發生，多胎妊娠的發生幾率較高。……