《中國比較醫學雜志》2017年總目次

《中國比較醫學雜志》2017年總目次

2017年 第27卷 1～12期

第1期

主編寄語

篳路藍縷創佳績 不忘初心再啟航

秦川(1)

研究報告

高脂飲食喂養建立高脂血癥模型的驗證及

規律探討

王燕萍，彭丹虹，劉曉琪，等(5)

Smad3對非小細胞肺癌A549細胞和宮頸癌

HeLa細胞遷移的影響

韋榮飛，李夢媛，楊星九，等(11)

厄洛替尼引起皮膚不良反應的小鼠模型建立

宋亞中，徐央波，鄧博，等(16)

不同時間點不同應激方法致大鼠焦慮樣行為的研究

趙洪慶，韓遠山，杜青，等(22)

比格犬蠕形螨病的診療與病理組織學觀察

溫福利，徐洪齊，熊愛蘭，等(27)

抑制IGFBP2、IGFBP3在卵巢腫瘤中的表達

對卵巢癌的遷移、侵襲的影響

李君，劉恩令，楊麗(32)

柯薩奇病毒A16型感染性模型的建立及其

相關免疫學指標和應用的評價

張鋒，高孟，高麗美，等(37)

廣東小鼠腺病毒血清學調查及病毒和抗體

在人工感染小鼠體內消長規律研究

羅銀珠，張鈺，潘金春，等(43)

補腎養血方對卵巢早衰大鼠中抗苗勒氏管激素

的影響

姬霞，傅金英，王冰玉，等(49)

氧化槐果堿對小鼠炎癥性疼痛的鎮痛作用研究

吳璟，楊文，鄭婕，等(54)

我國動物環境豐富研究論文的文獻計量分析

劉帥，李軍延(59)

羥乙基淀粉40氯化鈉注射液過敏實驗研究

宗衛峰，汪玉馨，劉洋，等(64)

TAK1抑制劑對糖尿病大鼠MAPK與NF-κB

信號通路的影響及其對腎臟保護機制

歐陽春，張里克，盧遠航，等(67)

淫羊藿苷對實驗性IgA腎病大鼠的作用及相關機制

張紅， 劉念， 李征(73)

技術方法

脂肪組織切片制備方法的改進

徐玉環，徐艷峰，劉穎，等(79)

巴斯德桿菌屬CODEHOP PCR檢測方法的

建立與初步應用

邢進，馮育芳，岳秉飛，等(85)

綜述與專論

人源腫瘤異種移植模型在精準腫瘤醫學

中的研究進展

李克娟，黃昊，高苒(91)

專家問答

不同類型的糖尿病動物模型血糖檢測在何時進行合適？

(78)

檢測血糖取血時，需要注意哪些事項？

(84)

第2期

研究報告

廣西巴馬小型豬PERV-env基因克隆及其

組織表達譜分析

鐘華，潘漢世，馬玲，等(1)

微量元素鍶改善大鼠非酒精性脂肪肝的

機制研究

姜慧玲，關橋偉，龔林，等(7)

小鼠脾臟間充質干細胞調節T淋巴細胞的

增殖與活化

丁麗，朱恒，張海宏，等(15)

裸小鼠胃癌原位移植模型的建立

田樹紅，王日超，肖敏，等(21)

斑馬魚幾種病原菌監測

馮麗萍，楊遲，林金杏，等(25)

大鼠子宮角瘺管模型的建立

侯金龍，袁超文，黃歡宇，等(29)

不同劑量酵母和腺嘌呤誘導大鼠

痛風性腎病模型的建立比較

藍倫禮，江濱，劉夢楚，等(33)

鹽酸格拉司瓊透皮貼劑在Beagle犬中

多劑量給藥的藥代動力學研究

陳姍姍，孫瑩瑩，韋陽，等(44)

人羊膜間充質干細胞移植后慢性酒精性

肝損傷大鼠血生化指標含量的變化

韓海燕，宋文廣，劉錦，等(49)

順鉑致兔急性腎損傷的序貫觀察

喬實，賈化平，梁會澤，等(55)

自發性糖尿病長爪沙鼠Rxra在6種

組織中的表達水平分析

龔菁菁，王存龍，李銀銀，等(59)

調查報告

2013年～2015年廣東地區實驗小鼠和大鼠

微生物學及寄生蟲學調查

潘金春，趙維波，陳梅玲，等(64)

經驗交流

小鼠體外寄生蟲的藥浴治療

翟青新(70)

綜述與專論

光遺傳技術在神經系統疾病動物模型中的應用

周瑞，秦川(74)

AAV載體靶向修飾策略在基因治療中的研究進展

鄧怡晨，劉云波(81)

外泌體在腫瘤診療中的研究進展

郭靜，徐桂英，黃昊，等(86)

神經電信號記錄與刺激系統在

深部腦電刺激治療中的應用

李瀟然，仲順安(93)

專家問答

(98)

廣告

(封二，封三，封底)

第3期

研究報告

束縛-應激聯合辣素灌胃建立大鼠腹瀉型

腸易激綜合征模型及評價

張濤，方健松，黃曉燕，等(1)

靶向性近紅外熒光染料在肝癌模型研究中的應用

趙寧寧，張彩琴，趙勇，等(8)

不同濃度Aβ25-35蛋白模擬阿爾茨海默病模型

學習記憶的差異

王 凱，李強，孫偉明，等(14)

人IL-37b在大腸埃希菌中的表達、純化

及活性鑒定

李夢媛，韋榮飛，徐大模，等(20)

利用實時細胞分析技術檢測胰腺癌細胞的藥物敏感性

靳亞西，孫彩顯，高虹，等(25)

E-cad在低位直腸癌淋巴結轉移

裸鼠模型血清及移植瘤中的表達及其意義

艾斯克爾·吐拉洪，陳凱，鄧大偉(31)

自擬葛花解酒滌脂湯對酒精性脂肪肝小鼠

肝臟脂肪沉積及PXR表達的影響

易旭，游紹偉，龍毅，等(36)

試驗相關因素對SD大鼠血液學指標的影響

程潔，環飛，靳蘇香，等(43)

三種雞胚絨膜尿囊膜移植瘤模型對比分析

費東亮，胡影，岳金金，等(47)

黃岑苷對實驗性自身免疫性腦脊髓炎小鼠的影響

任應國，張保朝，賈東佩，等(52)

實驗用小型豬乙型腦炎病毒的分離鑒定

王吉，付瑞，李曉波，等(57)

實驗小鼠血清中酯酶-1的檢測能力驗證結果評價

魏杰，王洪，鞏薇，等(63)

持續糖監測系統在兔低血糖模型中的應用評估

鄭一， 王楠(68)

技術方法

活體長爪沙鼠幽門螺旋桿菌檢測方法的建立

王存龍，李長龍，邢進，等(75)

動物籠具和墊料蒸汽滅菌條件的優化

陳 霆，張麗芳，金迎春，等(81)

一種用于局部紅外線照射的大鼠簡易固定裝置

鄭培鴻，陳維榮，林廣榮(84)

研究進展

α-細辛腦注射劑的研究進展與臨床應用

葉林虎，王宇奇，陶晨，等(87)

教學管理

醫學院校實驗動物學教學改革實踐與探討

張愛華，曾文滔(93)

細胞培養技術教學模式的探索與思考

曹蕊，嚴笠，孫雪健，等(96)

專家問答

小鼠、大鼠灌胃注意事項

(7)

裸鼠移植瘤造模注意事項

(92)

廣告

(封二，封三，封底)

第4期

研究報告

雙熒光標記的膠質瘤原位移植瘤模型的建立

李旺，黃焱，田新華，等(1)

蕨麻豬與巴馬小型豬臟器指數及低氧相關基因的比較

牛廷獻，王紅義，郭曉宇，等(9)

尼莫地平對H2O2誘導的PC12細胞凋亡的保護作用

李輝然 (14)

辛伐他汀對尾懸吊再負重大鼠長骨骨量恢復的影響

周沛飛，胡東，張巖，等(20)

海馬內微量注射K252a對大鼠行為學及

抑郁樣經典指標的影響

孟盼，朱青，張秀麗，等(26)

二脒那秦在肺動脈高壓模型大鼠中的預防和治療作用

周康，殷音，彭毅，等(34)

不同麻醉方法在幼齡貴州小型豬構建

顱骨缺損模型及修復術中麻醉效果的比較

曹春艷，胡正云，陳博(41)

慢病毒介導穩定敲低Smurf1細胞株的構建及

對細胞遷移的影響

韋榮飛，郭靜，李夢媛，等(46)

利用CRISPR-Cas9系統敲除小鼠黑色素瘤細胞系

MATP基因的初步研究

殷慧慧，李丹，李鈺，等(52)

Shkbp1缺失對小鼠 T淋巴細胞系亞群的影響

劉擎，張瀟涵，仰明明，等(56)

ICR小鼠下頜第一磨牙牙胚發育的動態組織學觀察

董寧，劉巖，張田田，等(63)

C57BL/6J小鼠凍融胚胎移植后所得小鼠及其

子代生物學特性數據測定與分析

徐偉超,顧劍潔,葛蓉, 等(69)

小鼠腦脊髓炎病毒自然感染調查以及

人工感染小鼠試驗

袁文，張鈺，黃碧洪，等(75)

單一情緒刺激與復合情緒刺激對

肝郁證動物模型作用的比較

石亮，孫佳惠，孫蓉(82)

母嬰分離應激對rd新生小鼠行為的影響

張傳領，邸桐，王文婧，等(89)

技術方法

基于THP-1細胞的皮膚致敏體外檢測方法

陳彧，喻歡，秦瑤，等(94)

簡訊

小型豬吹管麻醉方法介紹

劉天文，王帆，張杰民，等(68)

專家問答

(102)

廣告

(封二，封三，封底)

第5期

專題研究

SPF巴馬小型豬的培育及應用*

姜騫，韓凌霞，司昌德，等(1)

中國地鼠線粒體基因組與微衛星遺傳標記的研究*

宋國華，陳朝陽，劉田福，等(4)

化學物(藥物)毒性測試替代體系的建立及應用*

施暢，馬華智，王全軍，等(6)

長爪沙鼠NAFLD模型的建立及其遺傳學的研究*

劉月環，吳舊生，應華忠，等(9)

現代化中藥安全性評價和關鍵技術研究體系

的建立與應用*

胡雷,鐘飛,張彩霞，等(12)

小型豬慢性心肌缺血模型的建立與無創

遙測技術的應用*

陳民利，潘永明，陳亮，等(16)

研究報告

中國實驗動物行業發展現狀調查研究

孔琪(19)

血小板通過炎癥反應在鹽敏感性高血壓中

的作用機制研究

毛紅亞，劉云鵬，王子皓，等(23)

Fkbp51基因敲除對小鼠肝臟轉錄組基因

可變剪接的影響

周志強，楊志偉，雍偉東(31)

狨猴B2m基因沉默位點在細胞水平的驗證

鄧怡晨，張晨，向志光，等(37)

Kruppel樣因子6對肝癌HepG2細胞的作用

及其缺失對斑馬魚肝臟發育的影響

陳浩，楊振國，伍水龍，等(42)

宮腔注射無水乙醇對小鼠動情周期的影響

張引紅，王春芳，郭民，等(51)

布地奈德對哮喘小鼠模型IL-22的調控作用

王明磊，王文革，張俊紅，等(55)

松花粉對環磷酰胺增效減毒作用研究

鞏萍，孫銅，戴曉莉，等(60)

EGFR，PDCD4，TGF-β1，Smad3，Smad7在

中國地鼠口腔頰囊黏膜癌變過程中的表達研究

李莉紅,皇甫冰,高繼萍，等(64)

紫杉醇對實驗性自身免疫性腦脊髓炎大鼠

CD28、CTLA-4表達及BAFF的影響

張淑江，李作孝(71)

冠心寧片對大鼠心肌缺血再灌注損傷的

保護作用研究

胡飛，戎亦驪，朱科燕，等(76)

miR-221在H2O2誘導的大鼠心肌細胞損傷

中的作用及機制研究

符麗珍，黃茂芹，勞之勇，等(83)

脫氧紫色桿菌素抑制結腸癌TH29細胞增殖

及誘導凋亡作用與機制

張海燕，孫勇，夏惠，等(89)

技術方法

金黃色葡萄球菌、綠膿桿菌和肺炎克雷伯桿菌多重

PCR方法的建立與初步應用

祝巖波，鄭龍，尤紅煜，等(94)

一種新型大鼠動脈移植模型的建立

孫來龍，杜劍平，劉朝兵，等(99)

海外漫步

美國國家靈長類研究中心的運營管理及啟示

白杰英(103)

專家問答

HET和KO敲除鼠的區別

(3)

如何鑒定谷氨酸能神經元

(22)

*“2016年中國實驗動物學會科學技術獎”專題

第6期

研究報告

食蟹猴自發性高血壓及患病危險性的相關性研究

徐湘婷，韋祝梅，李振明，等(1)

右美托咪定鞘內注射對慢性神經痛模型大鼠

行為能力、疼痛程度和脊髓背角蛋白激酶C

表達的影響

孫虎，張亮，徐志新(6)

五指山小型豬、西藏小型豬和巴馬小型豬對

外源性脂肪的敏感性觀察

陳亮，潘永明，朱科燕，等(12)

阿爾茨海默病樣三重轉基因小鼠血小板的

功能改變及機制探討

劉遠新,劉濤(17)

SGT基因雜合缺失小鼠血液生理生化指標分析

顧取良，黃韌，鄶一賀，等(22)

miR-214通過靶向調控E2F3抑制肝癌細胞的增殖

杜朝陽，楊如玉，李超，等(27)

鼠傷寒沙門氏菌S.Typhimurium感染C57BL/6小鼠

腸道模型的建立及表型分析

韋榮飛，李夢媛，徐大模，等(33)

頸內動脈刺破法制作大鼠蛛網膜下腔出血模型

劉振剛，高建亮，孫林林，等(37)

改良麻醉方法對山羊麻醉效果的觀察

李想，張峰，沈保衛，等(46)

六種固定液對小鼠角膜固定效果的比較

高洪彬，林英，宋向榮，等(49)

技術方法

恒河猴大腦中動脈M1段栓塞建模中麻醉方案的選擇

田肇隆，馬艷輝，李麗，等(53)

實驗樹鼩空腸彎曲菌、沙門氏菌和志賀菌

多重熒光定量PCR方法的建立

馮育芳，王莎莎，邢進，等(56)

經驗交流

探討藥物GLP試驗用Beagle犬檢疫驗收的技術要點

孫昌華，劉毅，肖英，等(63)

流感病毒動物實驗生物安全實踐與探討

劉曉宇，鹿雙雙，池宏偉，等(68)

綜述與專論

乙型病毒性肝炎動物模型的比較分析

張倩，劉江寧，秦川(72)

HIV-1病毒與漿細胞樣樹突狀細胞的相互作用

彭卓穎，薛婧，魏強(77)

CD45分子在HIV-1病毒感染中的作用研究進展

李克雷，薛婧，魏強(82)

斑馬魚模型在常見骨疾病研究中的應用

王小琦，孫巖，張洋，等(86)

右心衰竭動物模型的建立和比較

王宇杰，左祥榮(92)

繼續教育

醫學研究生培養中的實驗室安全教育

王蓉(98)

專家問答

(67)

廣告

(封二，封三，封底)

第7期

研究報告

Fkbp51基因敲除小鼠心臟與肝臟RNA表達譜系的分析比較

武光東，邱彬，王婷婷，等(1)

幽門螺桿菌感染小鼠慢性胃炎模型的建立及評價

連大衛，扶麗君，許藝飛，等(6)

富氫液通過PI3K通路減輕大鼠腦缺血再灌注損傷

陳克研，董婉維 (13)

改良的兩步復合酶消化法制備大鼠胸主動脈

血管平滑肌細胞

周玥華，劉星，張艷軍，等(17)

小鼠間斷性禁食模型的建立及其對葡萄糖內穩態的影響

馬瀾婧，張浩浩，丁美玲，等(24)

猴B病毒抗體不同檢測方法的比對

李晉文，佟巍，蔡鵑，等(29)

昆明地區恒河猴、食蟹猴種群繁殖規律和繁殖性能研究

王宏，付學魏，陳智崗，等(34)

高通量測序法研究不同pH的飲用水

對SPF小鼠腸道微生物的影響

余強，劉月環，王志遠，等(40)

不同胎齡小鼠腦組織中神經干細胞

所占比例的研究

張鳳蘭，楊璐軍，朱紅梅，等(48)

公路運輸對新西蘭兔血液及生化指標的影響

余傳辛，高秀秀，萬梓成，等(53)

DB11/T828.3-2011中12號染色體標記篩選

及適用性評價研究

魏杰，王洪，于鵬麗，等(59)

腸系膜上靜脈血栓形成大鼠模型的建立

王陽，陳建立，陳俊卯，等(64)

低氧增強骨髓間充質干細胞增殖維持分化潛能

康少平，劉淑艷，李永升，等(70)

真菌性鼻竇炎大鼠鼻竇黏膜組織Maspin、IKKα

表達水平及意義

李琴，謝瓊(75)

長鏈非編碼 RNA CCAT1對人乳頭狀甲狀腺癌

侵襲和遷移能力的影響

劉麗云， 龔健，徐晉珩，等(81)

微衛星技術在NIH小鼠群體遺傳結構分析中的應用

郭羽，王洪，魏杰，等(87)

兔胚胎-胎仔發育毒性試驗中環磷酰胺

給藥方式的探討

孔菲菲，張彤，龔夏實，等(93)

研究進展

大鼠心肌缺血模型制備方法的比較及改進淺析

張世田，龐路路，唐漢慶，等(98)

影響體外鼠胚試驗標準化的要素分析

史建峰，韓倩倩，王春仁(102)

兔全身麻醉的研究進展

鄭靜，黃志，沈蓉，等(107)

專家問答

大鼠腦脊液抽取方法

(12)

常見分子影像設備的應用情況簡介

(97)

廣告

(封二，封三，封底)

第8期

專題研究

斑馬魚模型在糖尿病研究中的應用*

王雪，韓利文，何秋霞，等(1)

兩種2型糖尿病小鼠潰瘍創面愈合比較*

韓延忠，王玉芝，劉如華，等(6)

2 型糖尿病db/db小鼠的生物學特性*

邢瑋，王政霖，呂甜甜，等(12)

異常黑膽質證2型糖尿病大鼠模型的

血漿代謝組學研究*

巴哈古力·阿卜都熱合曼，

阿布力克木·毛拉尤甫，買吾拉尼江·依孜布拉，等(16)

運動對糖尿病大鼠胰島的影響及其機制探討*

龔云，張鑫(22)

參芍口服液調控TLR4/MyD88通路改善

糖尿病大鼠心肌炎癥損傷*

張紅利，賈春新，李海鷗，等(28)

研究報告

類風濕關節炎復合高血壓疾病模型的建立及評價

張影，周月，嚴尚學，等(34)

PKH26和Hoechst 33258聯合示蹤Uncv無毛小鼠

iRhom2及其突變體蛋白

游穎，陳丙波，曾林(40)

微衛星DNA分析國內24個近交系小鼠遺傳狀況

李銀銀，吳紹亮，王洪，等(43)

氣囊對腹壁撤退反射實驗結果的影響

趙妍，周思遠，羅丹妮，等(50)

尿酸排泄不良型高尿酸血癥動物模型的建立

沈桂芹，于世家(55)

肝癌人源腫瘤異種移植模型構建及初步應用

黃昊，李寶亮，楊星九，等(60)

C57BL/6J 小鼠凍融IVF原核胚用于Cas9

顯微注射探討

曾文滔，周建麗，趙書琴，等(66)

技術方法

經口氣管插管的定位評估防逆流裝置

的設計與效用評價

鮑禮智，朱玉峰，姜夢妮，等(70)

山羊肺泡巨噬細胞的分離、培養與鑒定

吉小芳，俞慧清，岳亮亮，等(75)

實驗動物四種病原體多重PCR方法的

建立與應用

祝巖波，徐增年，魏世錦，等(80)

研究進展

Hamartin在低氧/缺血耐受中的作用

侯林，許晟迪，張柱霞，等(85)

腹壁撤退反射實驗測量方法概述

陳穎，趙妍，羅丹妮，等(89)

教學管理

高校實驗動物從業人員培訓考核體系建設研究

姜鯤，湯宏斌(94)

江蘇省與浙江省實驗動物許可證發放及管理現狀對比

陳怡，宗衛峰，肖杭(98)

專家問答

小動物活體成像

(27)

活體成像的定量方式

(69)

*“糖尿病相關動物模型”專題

第9期

研究報告

不同方法誘導THP-1細胞分化效果比較

彭卓穎，叢喆，李想，等(1)

DBA/1J小鼠膠原誘導關節炎模型的

建立與鑒定

徐慧雯，郝文婷，陳德生，等(7)

氣滯血瘀證大鼠舌部基因表達譜變化初探

梁耀月，董世芬，程龍，等(11)

猴D型逆轉錄病毒p27基因的原核表達

及流式免疫熒光微球檢測技術的建立

劉助紅，王靜，李秀珍，等(17)

非人靈長類評價學習記憶功能的影響因素探討

李舸，劉曉霖，陳銳，等(24)

轉基因小鼠常見傳染病血清學液相芯片技術

多重檢測方法的建立

陳誠，朱科燕，褚燕青，等(30)

基于D-最優設計的SD大鼠皮膚

化學脫毛參數優化

許雅琦，徐德峰，趙子建，等(36)

土大黃根提取物對實驗性銀屑病小鼠

組織器官形態學的影響

艾西木江·熱甫卡提，

尤力都孜·買買提，阿不都熱衣木·肉孜，等(41)

靜脈注射大腸桿菌制備高動力型感染性

休克犬模型

崔嵩，韓葉葉，劉思伯(48)

中樞神經元中SEL1L基因缺失對小鼠

行為學的影響

王婧怡，劉青青，潘志雄，等(53)

肺癌人源性腫瘤組織異種移植模型的組織學

變化及其p63、napsin A和TTF-1的表達差異

方天，黃海榮，程熙，等(60)

miR-143通過負向調控Bcl-2抑制食管癌細胞的增殖

胡琛琛，張莉(65)

不同頻率音樂對小鼠空間學習記憶能力的影響

袁徐蕾，楊梅，韓文莉，等(71)

經驗交流

負壓屏障設施動物飼養籠具的選擇及其

感染風險的識別

向志光，佟巍，谷有剛，等(76)

大鼠心肌缺血再灌注實驗技巧的經驗總結

黃婷，李紹旦，楊明會，等(80)

教學管理

中南大學實驗動物屏障環境運行初期總結

丁燕霞，李琳，朱莉莉，等(83)

研究進展

實驗動物麻醉劑使用的福利倫理問題研究進展

李丹，郭玉瑩，鄧昊，等(87)

抑郁癥動物模型的研究進展

張磊陽，賀敏，李玥，等(92)

簡析猴B病毒在人類的致死性

李晉文，向志光(98)

大鼠腹膜粘連的模型構建與評價

鄭培鴻, 陳維榮(104)

專家問答

關于活體成像穿透深度的問題，比如做熒光、生物發光等實驗，活體成像穿透力大概的極限值是多少

(35)

通過光聲斷層掃描改良以后穿透力能提升多少

(97)

第10期

骨內單次注射辛伐他汀促進小鼠乳腺癌腫瘤血管

正常化的研究

海寶，劉燦，張穩，等(1)

不同樣本和方法對測定大鼠血液生化指標的影響

李迎，崔曉霞，尚世臣，等(7)

流式細胞術分析PMA誘導THP-1分化為巨噬細胞

的表型特征

彭卓穎，李想，叢喆，等(10)

熒光雙向電泳檢測雌雄小鼠肝組織蛋白組學的差異

戎卓娜，李慧玲，董鵬輝，等(16)

Mac-1基因缺失對黑色素瘤生長的影響

陳堅，段有發，葉志金，等(23)

1α，25(OH)2D3對大鼠關節軟骨細胞潤滑素

表達的影響

牛國棟，李思維，劉忠軍，等(28)

單染與復染在觀察SIRT1基因敲除小鼠骨關節炎

切片中的差異比較

于紅燕，楊占東，楊琪，等(34)

丹酚酸A改善ZDF大鼠視網膜病變及其作用機制

馬全鑫，陳小真，戎亦驪，等(40)

松花粉輔助紫杉醇聯合鉑類化療的增效減毒作用

趙學友，鞏萍，孫銅，等(47)

高熱大鼠不同程度寒顫模型的構建

吳冬梅，鄭翠紅，吳冠虹，等(51)

釩暴露對大鼠小膠質細胞炎癥反應和遷移的影響

余曉巍，胡楚元，熊志軍(55)

小鼠CD4+T細胞外泌體分離及鑒定

張偉鑫，曾仲(60)

廣東省2014～2016年普通級兔和豚鼠病毒抗體

監測與分析

吳瑞可，王靜，潘金春，等(65)

廣東省實驗用小型豬主要病原微生物學

及寄生蟲學調查

黃樹武，閔凡貴，吳瑞可，等(69)

miR-424對非小細胞肺癌細胞株A549遷移

及侵襲的影響

王勝，熊飛，開金丹(74)

siRNA沉默MACC1基因表達對宮頸癌細胞增殖

及侵襲的影響

杜珍，陳志美，周道秋，等(80)

研究進展

T細胞亞群在心室重構中的作用研究進展

顧文超，周曉慧，林芳，等(85)

肌萎縮側索硬化癥相關基因突變與疾病動物模型

張麗， 張連峰(89)

大鼠急性心肌梗死模型制備方法研究進展

曹玨，李貽奎，陳孟倩，等(96)

替代方法在化妝品檢測中的應用分析

程樹軍，秦瑤，柯逸暉，等(101)

嗎啡鎮痛個體差異的遺傳藥理學進展

楊銀，孟愛民(107)

免疫系統人源化小鼠模型的研究進展

連晶瑤，丁苗慧，秦國慧，等(113)

教學管理

醫藥院校實驗動物生物安全危害及防控

韓志剛，張倩，韓文莉，等(120)

基因突變動物模型在《醫學遺傳學》實驗教學

中的應用

唐佐青，霍學云，韓玉英，等(123)

專家問答

光聲斷層掃描系統介紹

(68)

活體成像的最新進展

(100)

簡訊

《中國實驗動物學報》《中國比較醫學雜志》入選《中國學術期刊(網絡版)》網絡首發首批示范期刊

(6)

第11期

研究報告

恒古骨傷愈合劑對骨折樹鼩血液生理和臟器系數

的影響

吳超，唐薇，趙宏斌，等(1)

非洲綠猴血液學和血清生化指標的測定及分析

周小軍，袁菊芳，定明，等(6)

恐傷孕鼠所產80日齡仔鼠認知發育與海馬區多巴胺、

二羥苯乙酸的相關性

李新民，楊麗萍，萬海嬌，等(10)

普通環境長爪沙鼠種群中病原體攜帶情況普查

戴方偉，杜江濤，周莎桑，等(15)

CKLF1-C19對昆明小鼠的急性毒性研究

朱琦，陳濤，劉蓉，等(19)

斑馬魚腫瘤異種移植模型在抗癌藥

敏感性評價中的應用

勞喬聰，徐懿喬，金凡茂，等(24)

豚鼠個體及品系間多態性微衛星位點篩選

衛振，洪勝輝，劉迪文(32)

芍藥苷對增殖性瘢痕成纖維細胞增殖抑制作用

及機制研究

王雷，馬園園，李亞玲，等(38)

IL-37b通過抑制樹突狀細胞相關的免疫應答

緩解感染性休克

李夢媛，燕正強，韋榮飛，等(44)

沙棘油對小鼠變應性接觸性皮炎的治療作用

沈琪，王梅，康金森(50)

卡介苗對膀胱腫瘤細胞及代謝產物的作用影響

吳金生，鄭傳秋，王清明，等(56)

調查報告

2016年北京地區實驗動物廢棄物處理方法的

調查與分析

張闊，田楓，康愛君，等(60)

技術方法

不同亮度環境下犬熒光留置針靜脈穿刺的

應用效果研究

楊莉，相磊，程艷爽，等(64)

牛病毒性腹瀉病毒RT-PCR方法的建立及應用

王吉，付瑞，李曉波，等(68)

經驗交流

一種易操作的小鼠肝細胞的分離及培養方法

范仕郡，劉鑫，楊東，等(75)

小鼠支氣管肺泡灌洗術的改進

姚茹，張銳虎，王璐，等(80)

移液槍在小鼠內眥取血中的應用

張穎，任波，田楓(84)

“3R”

做好醫院實驗動物福利保障工作的初步探討

余飛，錢麗萍，沙莉莉(87)

發表文獻中小鼠安死術方法的

分析研究(2015—2016)

岳東旭，池宏偉，鹿雙雙，等(91)

在精準醫學背景下，完善我國動物實驗質量與

福利倫理評價體系建設

張鈺，梁力均，張純(95)

研究進展

異質性胞核核糖核蛋白K與腫瘤研究的

最新進展

黃昊，楊星九，李夢媛，等(100)

結核病易感性的研究進展

孫萌萌，唐軍，秦川，等(106)

專家問答

常見的小鼠頸部非特異熒光顯影如何消除

(5)

磁共振MR在做脂肪代謝方面，比如關注小鼠脂肪增加或減少等情況，有什么技術上的特色

(79)

簡訊

《中國實驗動物學報》《中國比較醫學雜志》入選《中國學術期刊(網絡版)》網絡首發首批示范期刊

(83)

第12期

研究報告

敲除TRPC6對MPTP誘導小鼠神經炎性損傷的影響

王淑貞，尹紅，鐘耀藝，等(1)

子宮內膜異位癥盆腔粘連大鼠模型的建立與評價

李田田，孫偉偉，趙瑞華(8)

血清放置時間對大鼠血生化檢測的影響

康愛君，李雨薇，王學文，等(16)

下丘腦室旁核NMDAR介導大鼠促炎因子增強高血壓交感活動的作用

逯鵬，潘虹，馬春蕾，等(21)

姜黃素對沙漠干熱環境下大鼠腸黏膜損傷及氧化應激的影響

董翔，劉江偉，王金泉，等(28)

二甲雙胍對小鼠衰老過程中學習記憶能力的影響

張麗君，張麗霞，王郝瑩，等(33)

燕麥β-葡聚糖對膿毒癥小腸損傷相關基因表達的影響

吳昆鵬，陳瑩，黃治家，等(39)

谷甾醇-3-O-葡萄糖苷對瘢痕疙瘩成纖維細胞增殖、凋亡及膠原合成的影響

呂經緯，王佳婧，胡剛(46)

飛龍掌血提取物對高脂血癥心肌缺血小鼠氧化損傷的影響

劉明，鄧穎，劉楊，等(51)

羅格列酮對HT29、HCT116結腸癌細胞凋亡影響及機制探究

張琪，楊光華，葛志鵬，等(56)

低溫低壓環境對小鼠褐色脂肪組織形成的影響

仝永娟，楊朵，李娜，等(61)

中介素與腎上腺髓質素對局灶性腦缺血大鼠腦微循環的影響

郭鑫，王靜，王萌，等(66)

經皮電刺激對大鼠周圍神經端側吻合效果的影響

孫乾，曹群華，祝偉，等(73)

白藜蘆醇對大鼠血液高凝態的抑制作用及其與NF-κB表達的關系

王立文，沈曉潔，吳倩(79)

6-羥基多巴模型大鼠salsolinol氮甲基轉移酶活性檢測

張鎮松，柯酩，鄧玉林(84)

技術方法

小鼠多瘤病毒熒光PCR檢測方法的建立及其在裸鼴鼠感染情況調查中的應用

李曉波，付瑞，王淑菁，等(91)

水貂阿留申病毒、腸炎病毒與犬瘟熱病毒多重PCR檢測方法的建立與應用

馬芹，王元智，閆文卓，等(97)

超抗原葡萄球菌腸毒素B誘導IgA腎病小鼠模型的建立

史麗強，萬強，吳燕升，等(102)

研究進展

唾液酸黏附素Siglec-1在疾病中作用的研究進展

李克雷，李想，叢喆，等(109)

大、小鼠支氣管肺泡灌洗術的研究進展

龍隆，趙顯莉，譚紅，等(115)

糖皮質激素誘導小鼠骨質疏松模型構建方法的研究進展

李嘯群，錢進，蘇佳燦(120)

專家問答

將MR和活體成像整合在一起以后有什么優勢

(20)

影像實驗室的建設或選擇應考慮哪些問題？對建設規范有哪些要求？與動物房如何合理銜接？

(45)

簡訊

《中國實驗動物學報》入編《中文核心期刊要目總覽》2014年版(即第七版)之綜合性醫藥衛生的核心期刊

(1)

深切懷念施新猷教授

(125)

2017年總目次

(126)

《CHINESEJOURNALOFCOMPARATIVEMEDICINE》CUMMULATIVETABLEOFCONTENTSVol.27No.1-12 2017

No.1

Validation Research And Regulation Exploration Of High Fat-introduced Hyperlipidemia Model In Rat

WANGYan-ping，PENGDan-hong，LIUXiao-qi，etal.(5)

Effect of Smad3 on cell migration of A549 and HeLa cells

WEIRong-fei，LIMeng-yuan，YANGXing-jiu，etal.(11)

The establishment of mouse model of Erlotinib-induced skin adverse reactions

SONGYa-zhong，XUYang-bo，DENGBo，etal.(16)

Research of different methods of stress-induced anxiety-like behavior in rats at different time points

ZHAOHong-qing，HANYuan-shan，DUQing，etal.(22)

Treatment and pathological observation ofdemodexcanisin beagle dogs

WENFu-li，XUHong-qi，XiongAi-lan，etal.(27)

Effects of IGFBP2 and IGFBP3 expression in ovarian tumors on migration， invasion of ovarian cancer

LiJun，LiuEn-ling，YangLi(32)

Establishment of an animal model for coxsackievirus A16 infection related immunological evaluation

ZHANGFeng，GAOMeng，GAOLi-mei，etal.(37)

Serological Survey of Mad Infection Among Mice in Guangdong and Distribution and Serological Studies in Artificial Infection

LUOYin-zhu，ZHANGYu，PANJin-chun，etal.(38)

Effect of bushenyangxue prescription on the levels of anti-mullerian hormone in rat with premature ovarian failure

JIXia，FUJin-ying，WANGBing-yu，etal.(49)

Oxysophocarpine ameliorates carrageenan-induced inflammatory pain via inhibiting expressions of prostaglandin E2and cytokines in mice

WUJing，YANGWen，ZHENGJie，etal.(54)

Bibliometric study of the articles on environment enrichment in china

LIUShuai，LIJun-yan(59)

Experimental Study on Anaphylactoid Reactions of Hydroxyethyl Starch 40 Sodium Chloride Injection

ZONGWei-feng，WANGYu-xin，LiuYang，etal.(64)

Regulatory effect of TAK1 inhibitors on MAPK and NF-κB signaling pathway in diabetic rats and its renal protection mechanism

OUYang-chun，ZHANGLi-ke，LUYuan-hang，etal.(67)

Effects of Icariin of experimental IgA nephropathy in rats

ZHANGHong，LIUNian，LIZheng(73)

A modification of adipose tissue preparation

XUYu-huan，XUYan-feng，LIUYing，etal.(79)

Establishment and application of CODEHOP PCR assay for detection ofPasteurellaspp. in laboratory animals

XINGJin，FENGYu-fang，YUEBing-fei，etal.(85)

Research progress of patient-derived xenografts in precision cancer medicine

LIKe-juan，HUANGHao，GAORan(91)

No.2

Cloning of PERV-env in GXBM minipig and analysis of its tissue expression profile

ZHONGHua,PANHan-shi,MALing,etal.(1)

Mechanism of the trace element strontium on alleviating non-alcoholic fatty liver disease in rats

JIANGHui-ling,GUANQiao-wei,GONGLin,etal.(7)

Modulatory effects of mouse spleen-derived mesenchymal stem cells on the proliferation and activation of T lymphocytes

DINGLi,ZHUHeng,ZHANGHai-hong,etal.(15)

Establishment of an orthotopic gastric cancer model in nude mice

TIANShu-hong，WANGRi-chao，XIAOMin，etal.(21)

Monitoring of pathogenic bacteria in zebrafish

FENGLi-ping,YANGChi,LINJin-xing,etal.(25)

Establishment of a rat model of uterine horn fistula

HOUJin-long,YUANChao-wen,HUANGHuan-yu,etal.(29)

Comparison of the establishment of rat model of gouty nephropathy induced by yeast and adenine

LANLun-li,JIANGBin,LIUMeng-chu,etal.(33)

Pharmacokinetic study of granisetron hydrochloride transdermal patch by multiple administrations in beagle dogs

CHENShan-shan,SUNYin-yin,WEIYang,etal.(44)

Changes of blood biochemical indexes in the rats with chronic alcoholic liver injury after transplantation of human amniotic mesenchymal stem cells

HANHai-yan,SONGWen-gGuang,LIUJin,etal.(49)

Sequential observation of acute kidney injury induced by cisplatin in rabbits

QIAOShi，JIAHua-ping，LIANGHui-ze,etal.(55)

Analysis of Rxra expression in 6 tissues from spontaneous diabetic Mongolian gerbils

GONGJing-jing,WANGCun-long,LIYin-yin,etal.(59)

Microbiological and parasitological investigation in laboratory mice and rats in Guangdong Province from 2013 to 2015

PANJin-chun,ZHAOWei-bo,CHENMei-lin,etal.(64)

Medicated bath for eradication of external parasites in mice

ZHAIQing-xin(70)

Optogenetics and research progress in animal models of brain diseases

ZHOURui,QINChuan(74)

Progress in targeting modification strategy of AAV vector in gene therapy

DENGYi-chen，LIUYun-bo(81)

Research progress of exosomes in tumor diagnosis and treatment

GUOJing,XUEGui-ying,HUANGHao,etal.(86)

Application of neuroelectrical signal recording and neural stimulation system in deep brain stimulation therapy

LIXiao-ran,ZHONGShun-an(93)

No.3

Establishment and evaluation of a rat model of diarrhea-predominant irritable bowel syndrome by restraint-stress combined with capsaicin administration

ZHANGTao,FANGJian-song,HUANGXiao-yan,etal.(1)

Application of targeting near-infrared fluorescence dye in the study of liver cancer models

ZHAONing-ning,ZHANGCai-qin,ZHAOYong,etal.(8)

Aβ25-35protein in different concentrations to create a rat model resembling Alzheimer’s disease and the differences in their learning and memory ability

WANGKai,LIQiang,SUNWei-ming,etal.(14)

Expression, purification and activity assay of human IL-37b inE.coli

LIMeng-yuan,WEIRong-fei,XUDa-mo,etal.(20)

Drug sensitivity assessment of pancreatic cancer cells by real-time cell analysis

JINYa-xi,SUNCai-xian,GAOHong,etal.(25)

Expression and significance of E-cadherin in the serum and transplanted tumor of nude mouse model of low rectal cancer with lymph node metastasis

AISHIKEER·tulahong,CHENKai,DENGDa-wei(31)

Effect of Gehua Jiejue Dizhi decoction on the liver fatty deposition and expression of PXR in themousealcoholic fatty liver

YIXu,YOUShao-wei,LONGYi,etal.(36)

Effects of experiment-related factors on hematological parameters in SD rats

CHENGJie,HUANFei,JINSu-xiang,etal.(43)

Contrastive Analysis of three transplanted tumor models in chick embryo chorioallantoic membrane

FEIDong-liang,HUYing,YUEJin-jin,etal.(47)

Protective effect of Baicalin on experimental autoimmune encephalomyelitis in mice

RENYing-guo,ZHANGBao-chao,JIADong-pei,etal.(52)

Isolation and identification of Japanese encephalitis virus in the experimental minipigs

WANGJi,FURui,LIXiao-bo,etal.(57)

Evaluation report of the proficiency testing of serum esterase-1 in laboratory mice

WEIJie,WANGHong,GONGWei,etal.(63)

Evaluation of the value of application of continuous glucose monitoring system in a rabbit model of hypoglycemia

ZHENGYi,WANGNan(68)

Establishment of a detection method forHelicobacterpyloriin living Mongolian gerbil

WANGCun-long,LIChang-long,XINGJin,etal.(75)

Optimization of steam sterilization conditions for animal cages and beddings

CHENTing,ZHANGLi-fang,JINYing-chun,etal.(81)

A simple fastening device for local infrared irradiation in rats

ZHENGPei-hong,CHENWei-rong,LINGuang-rong(84)

Research progress and clinical application of α-asarone injection

YELin-hu,WANGYu-qi,TAOChen,etal.(87)

Practice and exploration on teaching reform of laboratory animal science in medical universities

ZHANGAi-hua,ZENGWen-tao(93)

Exploration and thinking of teaching model of cell culture technology

CAORui,YANLi,SUNXue-Jian,etal.(96)

No.4

Establishment of a nude mouse model of glioma orthotopic xenograft with double-fluorescent labeling

LIWang,HUANGYan,TIANXin-hua,etal.(1)

Comparison of organ coefficients and expression of hypoxia-related genes in the Bama and Juema minpigs

NIUTing-xian,WANGHong-yi,GUOXiao-yu,etal.(9)

Protective effect of nimodipine on PC12 cell apoptosis induced by H2O2

LiHui-ran(14)

Effect of simvastatin on bone mass recovery in rats with reloading after tail-suspension

ZHOUPei-fei,HUDong,ZHANGYan,etal.(20)

Changes of behavior and depression-like classic indicators after hippocampal microinjection of K252a

MENGPan,ZHUQing,XIANGYun,etal.(26)

Preventive and therapeutic effect of diminazene in the rat model of pulmonary arterial hypertension

ZHOUKang,YINYin,PENGYi,etal.(34)

Comparison of three anesthetic procedures during the establis-hment of and recovery effect on adolescent Guizhou minipig models of skull defect

CAOChun-yan,HUZheng-yun,CHENBo(41)

Establishment of two human tumor cell lines with lentivirus-mediated stably Smurf1 silencing and their effect on cell migration

WEIRong-fei,LIMeng-yuan,GUOJing,etal.(46)

A preliminary study on theMATPgene knockout in a mouse melanoma cell line using CRISPR-Cas9 system

YINHui-hui,LIDan,LiYu,etal.(52)

Effects of Shkbp1 deletion on mouse T lymphocyte subsets

LIUQing,ZHANGXiao-han,YANGMing-ming,etal.(56)

Establishment of first mandibular molar development of the time sequence in ICR mice

DONGNing,LIUYan,ZHANGTian-tian,etal.(63)

Mensurement and analysis of biological characteristics of C57BL/6J mice and their offsprings after frozen-thawed embryo transfer of C57BL/6J mice

XUWei-chao,GUJian-jie,GERong,etal.(69)

Investigation on the natural infection of Theiler’ s murine encephalomyelitis virus and study on experimental infection of the virus in mice

YUANWen，ZHANGYu，HUANGBi-hong，etal.(75)

Comparison of the effects of single emotional stimulus and complex emotional stimuli on the rat model of liver depression syndrome

SHILiang,SUNJia-hui,SUNRong(82)

Effect of maternal separation stress on behavior of neonatal rd mice

ZHANGChuan-ling,DITong,WANGWen-jing,etal.(89)

An in vitro skin sensitization test based on THP-1 cell line

CHENYu，YUHuan，QINYao，etal.(94)

No.5

Breeding and application of SPF Bama miniature pig

JIANGQian，HANLing-xia，SIChang-de，etal.(1)

Study of mitochondrial genomes and molecular genetic marker of microsatellite in chinese hamster

SONGGuo-hua，CHENZhao-yang，LIUTian-fu，etal.(4)

Establishment and application of toxicity testing alternative system for chemicals(new drugs)

SHIChang,MAHua-zhi,WANGQuan-jun，etal.(6)

Preliminarily genetic characterizations of nonalcoholic fatty liver disease mongolian gerbil

LIUYue-huan,WUJiu-sheng,YINGHua-zhong，etal.(9)

The establishment and application of safety evaluation and key technology research system for modem Chinese herbal drug

HULei,ZHONGFei,ZHANGCai-xia，etal.(12)

Establishment of chronic myocardial ischemia model in minipigs and application of noninvasive telemetry technique

CHENMin-li,PANYong-ming,CHENLiang，etal.(16)

Research on the development and present situation of laboratory animal industry in China

KONGQi(19)

The study on the mechanism of platelet in the development of salt-sensitive hypertension via inflammation

MAOHong-ya,LIUYun-peng,WANGZi-hao，etal.(23)

Effects ofFkbp51 gene knockout on the alternative splicing of liver transcriptome in mice

ZHOUZhi-qiang,YangZhi-wei,YONGWei-dong(31)

Validation of the silencing site of marmosetB2mgene at the cellular level

DENGYi-chen，ZHANGChen,XIANGZhi-guang，etal.(37)

Effects of Kruppel-like factor 6 on HepG2 and the development of liver in zebrafish

CHENHao,YANGZhen-guo,WUShui-long，etal.(42)

Effects of intrauterine injection of ethanol on estrous cycle in mice

ZHANGYin-Hong，WANGChun-fang，GUOMin，etal.(51)

Budesonide inhibits murine asthmatic airway inflammation through reduction IL-22 secretion

WANGMing-lei,WANGWen-ge,ZHANGJun-hong,etal.(55)

Synergism and attenuation effects of Pini Pollen on cyclophosphamide

GONGPing,SUNTong,DAIXiao-li，etal.(60)

The expression of EGFR，PDCD4，TGF-β1，Smad3 and Smad7 during oral buccal mucosa carcinogenesis in chinese hamster

LILi-hong,HUANGFu-bing,GaoJi-ping，etal.(64)

The effects of paclitaxel on the levels of CD28 ,CTLA-4 and BAFF in experimental autoimmune encephalomyelitis

ZHANGShu-jiang,LIZuo-xiao(71)

Study on the protective effect of Guanxinning Tablet on myocardial ischemia reperfusion injury in rats

HUFei,RONGYi-li,ZHUKe-yan，etal.(76)

The role of miR-221 in the injury induced by hydrogen peroxide in rat myocardial cells

FULi-zhen，HUANGMao-qin，LAOZhi-yong，etal.(83)

Effect of deoxyviolacein on inhibiting proliferation and inducing apoptosis of colon cancer HT29 cells

ZHANGHai-yan,SUNYong,XIAHui，etal.(89)

Establishment and application of a multiplex PCR method inStaphylococcusaureus、PseudomonasaeruginosaandKlebsiellapneumoniae

ZHUYan-bo，ZHENGLong,YOUHong-yu，etal.(94)

A new model of rat artery transplantation

SUNLai-long,DUJian-ping,LIUChao-bing，etal.(99)

Enlightements from work mechanism of the national primate research center in USA

BAIJie-ying(103)

No.6

Spontaneous hypertension in cynomolgus monkeys and an analysis of its risk factors

XUXiang-ting,WEIZhu-mei,LIZhen-ming,etal.(1)

Effect of intrathecal injection of dexmedetomidine on the behavioral activity, pain degree and expression of protein kinase C in the spinal dorsal horn in rat models of chronic neuropathic pain

SUNHu,ZHANGLiang,XUZhi-xin(6)

Observation on the sensitivity of Wuzhishan, Tibetan and Bama minipigs to exogenous fats

CHENLiang,PANYong-ming,ZHUKe-yan,etal.(12)

Changes of platelet function in Alzheimer-like triple transgenic mice and its mechanism

LIUYuan-xin,LIUTao(17)

Analysis of hematological and biochemical parameters of heterozygousSGT-deficient mice in young and elderly ages

GUQu-liang,HUANGRen,KUAIYi-he,etal.(22)

Inhibition of the proliferation of hepatocellular carcinoma cells by miR-214 via regulation of E2F3 expression

DUZhao-yang,YANGRu-yu,LIChao,etal.(27)

Etablishment and phenotypic analysis of a C57BL/6 mouse model ofS.Typhimuriuminfection

WEIRong-fei,LIMeng-yuan,XUDa-mo,etal.(33)

Preparation of a rat model of subarachnoid hemorrhage by a fiber core inserted in the internal carotid artery

LIUZhen-gang,GAOJian-liang,SUNLin-lin,etal.(37)

Observation of anesthetic effects of an improved anesthetic method on goat

LIXiang,ZHANGFeng,SHENBao-wei,etal.(46)

Comparison of the fixation effect of six types of fixatives on histology of mouse cornea

GAOHong-bin,LINYing,SONGXiang-rong,etal.(49)

Selection of anesthesia suitable for the establishment of a rhesus monkey model of M1 segment of middle cerebral artery occlusion

TIANZhao-long,MAYan-hui,LILi,etal.(53)

Establishment of a multiplex real-time PCR method for quantitative detection ofCampylobacterjejuni,SalmonellaandShigellain tree shrews

FENGYu-fang,WANGSha-sha,XINGJin,etal.(56)

Main technical points of quarantine inspection of Beagle dogs used for drug GLP experiment

SUNChang-hua,LIUYi,XIAOYing,etal.(63)

Practice and exploration of biosafety management in animal experiments on influenza virus

LIUXiao-yu,LUShuang-shuang,CHIHong-wei,etal.(68)

Comparative analysis of animal models of hepatitis B viral hepatitis

ZHANGQian，LIUJiang-ning，QINChuan(72)

Interaction of HIV-1 and plasmacytoid dendritic cells

PENGZhuo-ying，XUEJing，WEIQiang(77)

Research progress on the role of CD45 in HIV-1 infection

LIKe-lei，XUEJing，WEIQiang(82)

Application of zebrafish models in the research on bone diseases

WANGXiao-qi,SUNYan,ZHANGYang,etal.(86)

Establishment and comparison of right ventricular failure animal models

WANGYu-jie,ZUOXiang-rong(92)

No.7

Analysis and comparison of RNA expression profiles in the heart and liver ofFkbp51 knockout mice

WUGuang-dong,QIUBin,WANGTing-ting,etal.(1)

Establishment and evaluation of a mouse model of chronic gastritis induced byHelicobacterpylori

LIANDa-wei,FULi-jun,XUYi-fei,etal.(6)

Hydrogen-rich saline reduces cerebral ischemia-reperfusion injury in rats via PI3K pathway

CHENKe-yan,DONGWan-wei(13)

Preparation of rat thoracic aortic vascular smooth muscle cells by modified enzyme double digestion

ZHOUYue-hua,LIUXing,ZHANGYan-jun,etal.(17)

Establishment of a mouse model of intermittent fasting and characterization of its effect on glucose homeostasis

MALan-jing,ZHANGHao-hao,DINGMei-ling,etal.(24)

Comparison of different detection methods of monkey B virus antibody

LIJin-wen,TONGWei,CAIJuan,etal.(29)

Population reproductive regularity and reproductive performance of rhesus monkeys and cynomolgus monkeys in Kunming area

WANGHong,FUXue-wei,CHENZhi-gang,etal.(34)

Effect of drinking water at different pH on intestinal microbial diversity in SPF mice evaluated by 16S rRNA high throughput sequencing

YUQiang,LIUYue-huan,WANGZhi-yuan,etal.(40)

Proportion of neural stem cells in brain tissues of mice at different embryonic days

ZHANGFeng-lan,YANGLu-jun,ZHUHong-mei,etal.(48)

Effects of road transport on hematological and biochemical parameters in New Zealand rabbits

YUChuan-xin,GAOXiu-xiu,WANZi-cheng,etal.(53)

Screening of the makers of chromosome 12 and evaluate the applicability of Beijing Local Standard DB11/T828.3-2011

WEIJie,WANGHong,YUPeng-li,etal.(59)

Establishment of a rat model of superior mesenteric venous thrombosis

WANGYang,CHENJian-li,CHENJun-mao,etal.(64)

Hypoxia promotes proliferation of bone marrow mesenchymal stem cells and maintains their potential of differentiation

KANGShao-ping,LIUShu-yan,LIYong-sheng,etal.(70)

Expression and significance of Maspin and IKKα in sinusoidal mucosa of rats with fungal rhinosinusitis

LIQin,XIEQiong(75)

Effect of long non-coding RNA CCAT1 on invasion and migration of papillary thyroid cancer cells

LIULi-Yun,GONGJian,XUJin-Heng,etal.(81)

Application of microsatellite technology in the genetic structure analysis of NIH mice

GUOYu,WANGHong,WEIJie,etal.(87)

Administration mode of cyclophosphamide for the embryo-fetal developmental toxicity test in rabbits

KONGFei-fei,ZHANGTong,GONGXia-shi,etal.(93)

Comparison and improvement of the methods for establishment of rat models of myocardial ischemia

ZHANGShi-tian,PANGLu-lu,TANGHan-qing,etal.(98)

Analysis of factors affecting the standardization ofinvitromouse embryo test

SHIJian-feng,HANQian-qian,WANGChun-ren(102)

Progress in research on general anesthesia in rabbits

ZHENGJing,HUANGZhi,SHENRong,etal.(107)

No.8

Application of zebrafish models in research of diabetes

WANGXue,HANLi-wen,HEQiu-xia,etal.(1)

Comparison of wound healing in two mouse models of type 2 diabetes

HANYan-zhong,WANGYu-zhi,LIURu-hua,etal.(6)

Biological characteristics of a db/db mouse model of type 2 diabetes

XINGWei,WANGZheng-lin,LVTian-tian,etal.(12)

Plasma metabonomic study of abnormal Savdarat rat model of type 2 diabetes

ABUDUREHEMANBahagu-li，

MAOLAYOUFUAbulike-mu，HIZBILLAMawlan-jan,etal.(16)

Effect of aerobic exercise on pancreatic islets and exploration of their mechanism in type 2 diabetic rats

GONGYun，ZHANGXin(22)

Shenshao decoction improves myocardial inflammatory injury in diabetic rats by regulation of TLR4/MyD88 pathway

ZHANGHong-li，JIAChun-xin，LIHai-ou,etal.(28)

Establishment and evaluation of a rat model of arthritis-hypertension disease

ZHANGYing，ZHOUYue，YANShang-xue，etal.(34)

PKH26 combined with Hoechst 33258 to trace theiRhom2 gene and its mutant proteins of Uncv mice in Vero cells

YOUYing,CHENBing-bo,ZENGLin(40)

Genetic quality analysis of 24 domestic inbred mouse strains by microsatellite DNA

LIYin-yin，WUShao-liang，WANGHong，etal.(43)

Effect of air bag on the outcome of abdominal withdrawal reflex test

ZHAOYan，ZHOUSi-yuan，LUODan-ni，etal.(50)

Establishment of a rat model of hyperuricemia associated with uric acid excretion disorder

SHENGui-qin，YUShi-jia(55)

Establishment and application of a patient-derived xenograft mouse model of liver cancer

HUANGHao，LIBao-liang，YANGXing-jiu，etal.(60)

Frozen-thawed pronuclear embryos by invitrofertilization of C57BL/6J mice can be used for Cas9 microinjection

ZENGWen-tao，ZHOUJian-li,ZHAOShu-qin,etal.(66)

A simple and effective anti-backflow positioning evaluation device for orotracheal intubation in rats

BAOLi-zhi，ZHUYu-feng，JIANGMeng-ni，etal.(70)

Isolation, culture and identification of goat alveolar macrophages

…JIXiao-fang，YUHui-qing，YUELiang-liang，etal.(75)

Establishment and application of a multiplex PCR assay for four pathogens in laboratory animals

ZHUYan-bo，XUZeng-nian，WEIShi-jin，etal.(80)

The role of hamartin in ischemia/hypoxia tolerance

HOULin,XUSheng-di,ZHANGZhu-xia,etal.(85)

A summary of measurement methods for abdominal withdrawal reflex test

CHENYing，ZHAOYan，LUODan-ni，etal.(89)

Construction of training evaluation system for laboratory animal practitioners

JIANGKun，TANGHong-bin(94)

Comparison of license issuance and status of administration of Laboratory Animals in Jiangsu and Zhejiang provinces

CHENYi，ZONGWei-feng，XIAOHang(98)

No.9

Comparison of the effects of different treatments on THP-1 cell differentiation

PENGZhuo-ying,CONGZhe,LIXiang,etal.(1)

Establishment and characterization of a DBA/1J mouse model of collagen-induced arthritis

XUHui-wen,HAOWen-ting,CHENDe-sheng,etal.(7)

Preliminary study on changes in genome expression profiles of the tongue in rats with Qi-stagnation and blood stasis

LIANGYao-yue,DONGShi-fen,CHENGLong,etal.(11)

Prokaryotic expression ofp27 gene of simian type-D retrovirus and establishment of flow microsphere immunofluorescence assay

LIUZhu-hong,WANGJing,LIXiu-zhen,etal.(17)

Investigation of influencing factors on the evaluation of learning and memory in nonhuman primates

LIGe,LIUXiao-lin,CHENRui,etal.(24)

Establishment of a flexible multi-analyte profiling assay to detect common infectious disease antibodies in the serum of transgenic mice

CHENCheng,ZHUKe-yan,CHUYan-qing,etal.(30)

Optimization of chemical hair removal in SD rats by D-optimal design

XUYa-qi,XUDe-feng,ZhaoZi-jian,etal.(36)

Effects ofRumexL. root extract on the morphology of skin and some organs in mouse model of experimental psoriasis

Haximjan·Rapkat,Yultuz·Mamat,Abdiryim·Rozi,etal.(41)

Establishment of a dog model of hyperdynamic septic shock by intravenous injection ofEscherichiacoli

CUISong,HANYe-ye,LIUSi-bo(48)

Impact ofSEL1Ldeletion in central nervous system on the behavior of mice

WANGJing-yi,LIUQing-qing,PANZhi-xiong,etal.(53)

Histological changes and expression levels of p63, napsin A and TTF-1 in lung cancers and their patient-derived tumor xenograft models in nude mice

FANGTian,HUANGHai-rong,CHENGXi,etal.(60)

Inhibition of proliferation of esophageal cancer cells by miR-143 through negative regulation of Bcl-2 expression

HUChen-chen,ZhangLi(65)

Impact of music of different frequencies on the spatial learning and memory ability of mice

YUANXu-lei,YANGMei,HANWen-li,etal.(71)

Selection of laboratory animal cages and recognition of infection risk in the negative-pressure barrier facility

XIANGZhi-guang,TONGWei,GUYou-gang,etal.(76)

Experience and skills in the establishment of rat model of myocardial ischemia and reperfusion

HUANGTing,LIShao-dan,YANGMing-hui,etal.(80)

A preliminary summary of the management of laboratory animal barrier housing facilities at Central South University

DINGYan-xia,LILin,ZHULi-li,etal.(83)

Research progress on ethical issues of anesthetics application in laboratory animals

LIDan,GUOYu-ying,DENGHao,etal.(87)

Research progress on animal models of depression

ZHANGLei-yang,HEMin,LIYue,etal.(92)

A glance at the lethality of monkey B virus in humans

LiJin-wen,XIANGZhi-guang(98)

A review of the establishment and evaluation of rat model of peritoneal adhesions

ZHENGPei-hong,CHENWei-rong(104)

No.10

Study on the effect of single dose intraosseous injection of simvastatin on tumor vascular normalization in murine breast cancer

HAIBao，LIUCan，ZHANGWen，etal.(1)

Effects of different samples and methods on the determination of blood biochemical indexes in rats

LIYing，CUIXiao-xia，SHANGShi-chen，etal.(7)

Phenotypic characterization of PMA-induced THP-1 macrophages analyzed by flow cytometry

PENGZhuo-ying，LIXiang，CONGZhe，etal.(10)

Differential proteomic analysis of liver tissues between male and female C57BL/6J mice by 2D-DIGE

RONGZhuo-na，LIHui-ling，DONGPeng-hui，etal.(16)

Effect ofMac-1 deficiency on the tumor growth of melanoma in mice

CHENJian，DUANYou-fa，YEZhi-jin，etal.(23)

1α，25(OH)2D3regulates expression of lubricin of chondrocytes in rat articular cartilage

NIUGuo-dong，LISi-wei，LIUZhong-jun，etal.(28)

Observation of the articular cartilage of osteoarthritis inSIRT1 gene knock-out mice through single staining and compound staining

YUHong-yan，YANGZhan-dong，YANGQi，etal.(34)

Effect of salvianolic acid A on retinopathy and its mechanism in ZDF rats

MAQuan-xin，CHENXiao-zhen，RONGYi-li，etal.(40)

Synergism and attenuation effects of Pini Pollen on paclitaxel and cisplatine chemotherapy

ZHAOXue-you，GONGPing，SUNTong，etal.(47)

Establishment of rat models of fever and shivering in different degrees

WUDong-mei，ZHENGCui-hong，WUGuan-hong，etal.(51)

Exposure to vanadium promotes primary cultured rat microglial inflammation and migration

YUXiao-wei，HUChu-yuan，XIONGZhi-jun(55)

Isolation and identification of exosomes of CD4+T cells in mice

ZHANGWei-xin，ZENGZhong(60)

Surveillance and analysis of virus antibodies in conventional rabbits and guinea pigs in Guangdong Province during 2014-2016

WURui-ke，WANGJing，PANJin-chun，etal.(65)

Microbiological and parasitological investigation of experimental minipigs in Guangdong province

HUANGShu-wu，MINFan-gui，WURui-ke，etal.(69)

Effect of miR-424 on migration and invasion of non-small cell lung cancer cells A549

WANGSheng，XIONGFei，KAIJin-dan(74)

Effect of silencing MACC1 gene on proliferation and invasion of cervical cancer cells

DUZhen，CHENZhi-mei，ZHOUDao-qiu，etal.(80)

Advances in research on the role of T cell subsets in ventricular remodeling

GUWen-chao，ZHOUXiao-hui，LINFang，etal.(85)

Amyotrophic lateral sclerosis-associated gene mutations and ALS animal models

ZHANGLi，ZHANGLian-feng(89)

Research progress on preparation of rat models of acute myocardial infarction

CAOJue，LIYi-kui，CHENMeng-qian，etal.(96)

The application analysis of alternative method in cosmetics asssessment

CHENGShu-Jun，QINYao，KEYI-Hui，etal.(101)

Genetic pharmacology of individual differences in morphine analgesia

YANGYin，MENGAi-min(107)

Research progress of humanized mouse models in immune system

LIANJing-yao，DINGMiao-hui，QINGuo-hui，etal.(113)

Biosafety hazard of laboratory animals in medical colleges and its prevention and control

HANZhi-gang，ZHANGQian，HANWen-li，etal.(120)

Application of mutated inbred animal models in the experimental teaching of medical genetics

TANGZuo-qing，HUOXue-yun，HAN-Yu-ying，etal.(123)

No.11

Effect of Osteoking on blood physiological parameters and organ indexes in female tree shrews with osteoporotic fracture

WUChao,TANGWei,ZHAOHong-bin,etal.(1)

Measurement and analysis of hematologic and serum biochemical parameters in African green monkeys

ZHOUXiao-jun,YUANJu-fang,DINGMing,etal.(6)

Correlation between cognitive development and levels of dopamine and 3,4-dihydroxyphenylacetic acid in the hippocampus in 80-day-old neonatal rats born of fear-impaired pregnant rats

LIXin-min,YANGLi-ping,WANHai-jiao,etal.(10)

Investigation of pathogen infections in Mongolian gerbils raised in a conventional facility

DAIFang-wei,DUJiang-tao,ZHOUSha-sang,etal.(15)

Exploration of acute toxicity effect of CKLF1-C19 on KM mice

ZHUQi,CHENTao,LIURong,etal.(19)

Applications of zebrafish xenotransplantation models forinvivoevaluation of anticancer drug sensitivity test

LAOQiao-cong,XUYi-qiao,JINFan-mao,etal.(24)

Screening of microsatellite loci with polymorphism among individuals and strains of guinea pigs

WEIZhen,HONGSheng-hui,LIUDi-wen(32)

Inhibitory effect and mechanism of paeoniflorin on proliferation of hypertrophic scar fibroblasts

WANGLei,MAYuan-yuan,LIYa-ling,etal.(38)

IL-37b alleviates septic shock through inhibition of immune responses related to dendritic cells

LIMeng-yuan,YANZheng-qiang,WEIRong-fei,etal.(44)

Therapeutic effect of sea buckthorn oil on allergic contact dermatitis in mice

SHENQi,WANGMei,KANGJin-sen(50)

Effect of BCG on bladder cancer cells and their metabolites in rats

WUJin-sheng,

ZHENGChuan-qiu,WANGQing-ming,etal.(56)

Investigation and analysis of laboratory animal waste disposal in Beijing area in 2016

ZHANGKuo,TIANFeng,KANGAi-jun,etal.(60)

Application value of fluorescent intravenous indwelling catheter in dogs under different brightness conditions

YANGLi,XIANGLei,CHENGYan-shuang,etal.(64)

Establishment and application of a RT-PCR detection method for bovine viral diarrhea virus

WANGJi,FURui,LIXiao-bo,etal.(68)

A simplified method for isolation and culture of primary mouse hepatocytes

FANShi-jun,LIUXin,YANGDong,etal.(75)

Technical improvement of bronchoalveolar lavage in mice

YAORu,ZHANGRui-hu,WANGLu,etal.(80)

Use of a pipettor for blood collection from the inner canthus of mice

ZHANGYing,RENBo,TIANFeng(84)

A preliminary discussion on how to protect laboratory animal welfare in the hospital

YUFei,QIANLi-ping,SHALi-li(87)

Analysis of current status of mouse euthanasia methods based on the publications in China(2015 - 2016)

YUEDong-xu,CHIHong-wei,LUShuang-shuang,etal.(91)

To improve the construction of evaluation system for qualities and welfare ethics of animal experiments in China based on the background of precision medicine

ZHANGYu,LIANGLi-jun,ZHANGChun(95)

Recent progress in research of heterogeneous nuclear ribonucleoprotein K related with tumor pathogenesis and progression

HUANGHao,YANGXing-jiu,LIMeng-yuan,etal.(100)

Progress in research on the susceptibility of tuberculosis

SUNMeng-meng,TANGJun,QINChuan,etal.(106)

No.12

Effect of TRPC6 knock-out on the mouse neuroinflammation induced by MPTP

WANGShu-zhen，YINHong，ZHONGYao-yi，etal.(1)

Establishment and evaluation of a rat model of endometriosis with pelvic adhesions

LITian-tian，SUNWei-wei，ZHAORui-hua(8)

Effect of storage time on serum biochemical test of rats

KANGAi-jun，LIYu-wei，WANGXue-wen，etal.(16)

NMDAR in paraventricular nucleus mediates enhanced sympathetic activities caused by pro-inflammatory cytokines in spontaneously hypertensive rats

LUPeng，PANHong，MAChun-lei，etal.(21)

Protective effect of curcumin on the intestinal injury and oxidative stress in rats in dry and hot desert environment

DONGXiang，LIUJiang-wei，WANGJin-quan，etal.(28)

Effect of metformin on learning and memory ability in mice during aging and the possible underlying mechanisms

ZHANGLi-jun，ZHANGLi-xia，WANGHao-ying，etal.(33)

Effects of oat β-glucan on the expression of small intestine injury-related genes in septic rats

WUKun-peng，CHENYing，HUANGZhi-jia，etal.(39)

Effect of sitostero-3-O-glucoside on proliferation, apoptosis and collagen synthesis of keloid fibroblasts

LVJing-wei，WANGJia-jing，HuGang(46)

Protective effects ofToddaliaasiaticaextract on oxidative damages in mice with myocardial ischemia and hyperlipidemia

LIUMing，DENGYing，LIUYang，etal.(51)

Rosiglitazone promotes apoptosis in colon cancer HT29 and HCT116 cells through AKT/GSK3β signalling pathway

ZHANGQi，YANGGuang-hua，GEZhi-peng，etal.(56)

Effect of hypobaric hypoxia and cold exposure on formation of brown adipose tissue in mice

TONGYong-juan，YANGDuo，LINa，etal.(61)

Effect of intermedin and adrenomedullin on cerebral microcirculation in rat models of cerebral ischemia

GUOXin，WANGJing，WANGMeng，etal.(66)

Promoting effect of percutaneous electrical stimulation on nerve regeneration after end-to-side neurorrhaphy in rats

SUNQian，CAOQun-hua，ZHUWei，etal.(73)

Inhibitory effect of resveratrol on the hypercoagulable state in rats and its relationship with the expression of NF-κB

WANGLi-wen，SHENXiao-jie，WUQian(79)

Determination of salsolinol N-methyltransferase activity in 6-OHDA-lesioned rats

ZHANGZhen-song，KEMing，DENGYu-lin(84)

Establishment of a fluorescence quantitative PCR assay for murine polyomavirus detection and its use in the detection in naked mole rats

LIXiao-bo，FURui，WANGShu-jing，etal.(91)

Establishment and application of a multiplex PCR assay for detection of Aleutian disease parvovirus, enteritis parvovirus and canine distemper virus in the mink

MAQin，WANGYuan-zhi，YANWen-zhuo，etal.(97)

Establishment of a mouse model of IgA nephropathy induced by superantigen staphyococcal enterotoxin B

SHILi-qiang，WANQiang，WUYan-sheng，etal.(102)

Advances in research on the role of Siglec-1 in diseases

LIKe-lei,LIXiang,CONGZhe，etal.(109)

Research progress of bronchoalveolar lavage in rats and mice

LONGLong，ZHAOXian-li，TANHong，etal.(115)

Current status of research on glucocorticoid-induced mouse models of osteoporosis

LIXiao-qun，QIANJin，SUJia-can(120)