SAA和CRP聯合檢測在小兒感染性疾病鑒別診斷中的應用價值評價

石就家+葉依娜+湯志良

[摘要]目的 分析研究血清淀粉樣蛋白A（SAA）和C-反應蛋白（CPR）在小兒感染性疾病鑒別診斷中的應用價值。方法 選取我院2015年3月～2017年2月間收治的小兒感染性疾病患兒500例作為研究對象，按照其細菌培養或者病毒鑒別的結果將其分為細菌性感染組（293例）和病毒性感染組（207例），分別對其SAA、CRP等指標進行檢測，并取同期接受體檢的健康兒童各200例作為對照，行相同檢測，比較各組受檢兒童兩項指標檢測結果之間的差異。同時計算SAA、CRP單獨或聯合診斷小兒細菌性感染性疾病的靈敏度、特異性以及準確度。結果 對各組兒童的SAA和CRP檢測結果進行比較，均有細菌性感染組患兒顯著高于病毒性感染組患兒和健康兒童的情況，其中病毒性感染組患兒的SAA顯著高于健康兒童，差異有統計學意義（P<0.05）。對SAA、CRP單獨或聯合診斷小兒細菌性感染性疾病的靈敏度、特異性以及準確度進行比較，則有聯合診斷顯著優于SAA或CRP單獨診斷的效果比較有統計學差異（P<0.05）。結論 聯合應用SAA與CRP對感染性疾病患兒進行診斷，不僅能對患兒的患病情況進行診斷，還能對細菌性感染與病毒性感染進有效鑒別，操作簡便易行，特異性俱佳，是一項理想的診斷指標。

[關鍵詞] SAA；CRP；小兒感染性疾病；診斷鑒別

[中圖分類號] R725 [文獻標識碼] A [文章編號] 2095-0616（2017）20-72-03

Evaluation of combined use of SAA and CRP in the differential diagnosis of infectious diseases in children

SHI Jiujia YE Yi'na TANG Zhiliang

Department of Pediatrics， the Third Peoples Hospital of Nanhai District， Foshan 528244， China

[Abstract] Objective To investigate the value of serum amyloid A（SAA） and C- reactive protein（CPR） in the differential diagnosis of infectious diseases in children. Methods 500 cases children admitted to the pediatric infectious disease was selected as the research object in our hospital between March 2015 and February 2017， they were divided into bacterial infection group（293 cases） and viral infection group（207 cases） according to the identification of the virus or bacteria ， were used to detect the SAA， CRP and other indicators. 200 cases healthy children underwent as control， for the same detection， compared the differences between all groups by the two indicators of child detection results， calculated the sensitivity， specificity and accuracy of SAA and CRP alone or in combination for the diagnosis of bacterial disease in children. Resluts Bacterial infection group with SAA and CRP test results were significantly higher than the group of viral infection children and healthy children， the virus infections SAA test results were significantly higher than in healthy children， the difference was statistically significant（P<0.05）. The sensitivity， specificity and accuracy of combined diagnosis of SAA and CRP in children with bacterial susceptibility diseases were significantly better than those of SAA or CRP， and there was a statistically significant difference between them（P<0.05）. Conclusion The combined application of SAA and CRP for diagnosis of infectious diseases in children， can not only diagnose the prevalence of children， but also to bacterial infection and virus infection in effective identification， simple operation， high specificity， is an ideal diagnostic index.endprint