注射用鼠神經(jīng)生長(zhǎng)因子聯(lián)合利培酮治療兒童孤獨(dú)癥的臨床療效分析

周小琳 陳雪貞 李棟方 何展文 羅向陽(yáng)

摘 要：目的 探討注射用鼠神經(jīng)生長(zhǎng)因子聯(lián)合利培酮治療兒童孤獨(dú)癥的臨床療效。方法 選取我院小兒神經(jīng)專(zhuān)科收治的65例兒童孤獨(dú)癥患兒，隨機(jī)分為兩組，對(duì)照組31例患兒?jiǎn)斡美嗤委煟委熃M34例患兒予注射用鼠神經(jīng)生長(zhǎng)因子聯(lián)合利培酮治療。所有患兒均在治療前和治療后3個(gè)月進(jìn)行ABC量表、CARS量表評(píng)定，對(duì)比兩組患兒量表評(píng)分情況及臨床有效率。結(jié)果 治療后，治療組ABC量表中感覺(jué)能力、交往能力、運(yùn)動(dòng)能力、語(yǔ)言能力及自我照顧5項(xiàng)評(píng)分均優(yōu)于對(duì)照組（P<0.05）；對(duì)照組和治療組CARS量表總分均比治療前降低（P<0.05），治療組與對(duì)照組相比，CARS量表總分降低更明顯（P<0.05）。治療組臨床有效率為94.11%，高于對(duì)照組的77.42%，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 注射用鼠神經(jīng)生長(zhǎng)因子聯(lián)合利培酮較利培酮單藥治療兒童孤獨(dú)癥療效更佳，不良反應(yīng)少。

關(guān)鍵詞：注射用鼠神經(jīng)生長(zhǎng)因子；利培酮；兒童孤獨(dú)癥

中圖分類(lèi)號(hào)：R749.94 文獻(xiàn)標(biāo)識(shí)碼：A DOI：10.3969/j.issn.1006-1959.2018.17.019

文章編號(hào)：1006-1959（2018）17-0063-03

Abstract：Objective To investigate the clinical efficacy of injection of mouse nerve growth factor combined with risperidone in the treatment of childhood autism.Methods A total of 65 children with autism admitted to our hospital were randomly divided into two groups.31 patients in the control group were treated with risperidone alone，34 patients in the treatment group were treated with injection of mouse nerve growth factor combined with risperidone.All children were assessed on the ABC scale and CARS scale before treatment and 3 months after treatment，and the scores and clinical effectiveness of the two groups were compared.Results After treatment，the scores of sensory ability，communication ability，exercise ability，language ability and self-care in the ABC scale of the treatment group were better than those of the control group（P<0.05），the total scores of CARS scales in the control group and the treatment group were lower than those before treatment（P<0.05）.Compared with the control group，the total score of the CARS scale was significantly lower in the treatment group（P<0.05）.The clinical effective rate was 94.11% in the treatment group，which was higher than 77.42% in the control group，the difference was statistically significant（P<0.05）.Conclusion The injection of mouse nerve growth factor combined with risperidone is better than risperidone in the treatment of childhood autism with less adverse reactions.

Key words：Mouse nerve growth factor for injection；Risperidone；Childhood autism

兒童孤獨(dú)癥譜系障礙（autism spectrum disorder，ASD）又稱(chēng)自閉癥，是一組以語(yǔ)言發(fā)育落后、社交障礙、興趣或活動(dòng)范圍狹窄及刻板動(dòng)作為特征的神經(jīng)發(fā)育障礙性疾病[1]。孤獨(dú)癥患兒除了以上核心癥狀外，很多還合并精神運(yùn)動(dòng)發(fā)育遲緩，伴有多動(dòng)、沖動(dòng)、攻擊他人等異常行為，預(yù)后較差，給家庭和社會(huì)造成巨大的負(fù)擔(dān)。目前尚無(wú)特效藥物治療孤獨(dú)癥，針對(duì)患兒伴隨的異常精神行為可以采用一些抗精神病藥物、抗抑郁藥物治療等。有報(bào)道，利培酮應(yīng)用于兒童孤獨(dú)癥的治療有一定臨床效果，可以改善患兒的攻擊、自傷、多動(dòng)等異常行為，而腦神經(jīng)營(yíng)養(yǎng)藥物例如鼠神經(jīng)生長(zhǎng)因子對(duì)孤獨(dú)癥患兒有一定的治療作用[2，3]。本研究探討注射用鼠神經(jīng)生長(zhǎng)因子聯(lián)合利培酮治療兒童孤獨(dú)癥的臨床療效，現(xiàn)報(bào)道如下。……