年齡對胃部常見良性疾病患者的胃蛋白酶原及胃泌素—17水平的影響

潮子健 汪文生 謝宏偉

摘 要：目的 研究年齡對胃部常見良性疾病患者的胃蛋白酶原（PG）及胃泌素-17（G-17）水平的影響。方法 收集2016年1月～2017年12月在安徽醫(yī)科大學(xué)附屬安慶醫(yī)院消化內(nèi)科住院患者的病歷作為研究材料，根據(jù)疾病將其分為慢性非萎縮性胃炎（CNAG）組、胃息肉組及胃潰瘍組，共收集2638份符合條件的病歷。將上述三組疾病按照年齡進(jìn)一步分為高齡亞組（≥60歲）及低齡亞組（<60歲），每個亞組按男女性別再分為兩個次級亞組。按照隨機(jī)數(shù)字表法，將符合條件的患者資料隨機(jī)分到每個次級亞組中，每組40例，一共收集480例資料作為樣本進(jìn)行分析。使用雙抗體夾心法的酶學(xué)免疫分析技術(shù)檢測各組患者的胃蛋白酶原Ⅰ（PGⅠ）、胃蛋白酶原Ⅱ（PGⅡ）及G-17水平，并計算出PGⅠ/PGⅡ的比值PGR。結(jié)果 在CNAG及胃息肉組中，高齡亞組的PGⅠ、PGⅡ和G-17水平均高于低齡亞組、PGR水平低于低齡亞組，差異有統(tǒng)計學(xué)意義（P<0.05）。在胃潰瘍組中，高齡亞組的PGⅠ、PGⅡ及G-17水平均高于低齡亞組、PGR水平低于低齡亞組，差異無統(tǒng)計學(xué)意義（P>0.05）。結(jié)論 在CNAG及胃息肉組中，年齡對胃蛋白酶原及G-17水平有影響，但在胃潰瘍組中，年齡對胃蛋白酶原及G-17水平的無明顯影響。

關(guān)鍵詞：年齡；非萎縮性胃炎；胃息肉；胃潰瘍；胃蛋白酶原；胃泌素-17

中圖分類號：R573 文獻(xiàn)標(biāo)識碼：A DOI：10.3969/j.issn.1006-1959.2018.23.028

文章編號：1006-1959（2018）23-0105-03

Abstract：Objective The effect of age on pepsinogen （PG） and gastrin-17（G-17） levels in patients with common benign diseases of the stomach was studied. Methods From January 2016 to December 2017， the medical records of inpatients in the Department of Gastroenterology， Anqing Hospital affiliated to Anhui Medical University were collected as research materials. According to the disease， they were divided into chronic non-atrophic gastritis（CNAG） group， gastric polyp group and gastric ulcer. Group， a total of 2638 eligible medical records were collected. The above three groups of diseases were further divided into the older subgroup （≥60 years old） and the younger subgroup（<60 years old） according to age， and each subgroup was subdivided into two subgroups according to gender. According to the random number table method， the eligible patient data were randomly assigned to each sub-subgroup， 40 cases in each group， and a total of 480 samples were collected for analysis. The pepsinogen I（PGI）， pepsinogen II （PGII） and G-17 levels of each group of patients were measured by enzymatic immunoassay using a double antibody sandwich method， and the PGI/PGII ratio PGR was calculated. Results In the CNAG and gastric polyp group， the PGI， PGII and G-17 levels in the older subgroup were higher than those in the younger subgroup and the PGR level was lower than the lower subgroup，the difference was statistically significant（P<0.05）. In the gastric ulcer group， the PGI， PGII and G-17 levels in the older age group were higher than those in the younger subgroup and the PGR level was lower than the younger subgroup， and the difference was not statistically significant（P>0.05）. Conclusion Age has an effect on pepsinogen and G-17 levels in the CNAG and gastric polyp groups， but in the gastric ulcer group， age has no significant effect on pepsinogen and G-17 levels.

Key words：Age；Non-atrophic gastritis；Gastric polyps；Gastric ulcer；Pepsinogen；Gastrin-17

胃蛋白酶原（pepsinogen，PG）在結(jié)構(gòu)上屬于天冬氨酸蛋白酶，本身無活性，在酸性環(huán)境里可轉(zhuǎn)變?yōu)榫哂猩锘钚缘奈傅鞍酌福渲饕姆置趫鏊俏葛つは袤w細(xì)胞。根據(jù)生化及免疫性質(zhì)的不同，它可分為胃蛋白酶原Ⅰ（PGⅠ）和胃蛋白酶原Ⅱ（PGⅡ）[1]。胃泌素（gastrin，G）是一種肽類激素，主要由胃竇及十二指腸近端黏膜的G細(xì)胞分泌，有很多亞型，其中胃泌素-17（G-17）是胃竇中胃泌素的主要形式，為進(jìn)餐后血液中胃泌素的主要形式。通過測定患者的PG及G-17水平，可以反映胃黏膜的功能狀態(tài)[2]，對胃黏膜起到“血清學(xué)活檢[3]”的作用，相較于胃鏡及影像學(xué)檢查，該檢查經(jīng)濟(jì)、簡便、安全性高，因此在臨床應(yīng)用上受到廣泛重視。本研究回顧性分析480例胃部常見良性疾病患者的血清PG、G-17水平和相關(guān)的臨床資料，探討年齡因素對PG及G-17水平的影響。……