自擬柴苓飲聯合干擾素及利巴韋林治療慢性丙型肝炎的臨床研究

吳藝鋒

[摘要] 目的 探討自擬中藥方柴苓飲聯合干擾素及利巴韋林治療慢性丙型肝炎的臨床療效。 方法 選取2014年1月～2018年5月期間在我院接受慢性丙型肝炎治療的患者26例，將所選患者隨機分為研究組與對照組，對照組患者接受聚乙二醇干擾素α-2a與利巴韋林治療，研究組同時加用自擬中藥方柴苓飲治療，并對兩組患者進行為期6個月的隨訪。對兩組患者改善肝臟硬度的有效率、血清谷丙轉氨酶（ALT）、谷草轉氨酶（AST）、堿性磷酸酶（ALP）以及γ-谷氨酰轉移酶（GGT）的指標以及白蛋白（ALB）、球蛋白（GLB）、白蛋白/球蛋白（A/G）的改善情況進行比較。 結果 研究組改善肝臟硬度的有效率高于對照組，差異有統計學意義（P<0.05）;研究組患者血清中ALT、AST、ALP以及GGT水平低于對照組，差異有統計學意義（P<0.05）;研究組治療后的ALB、GLB、A/G的改善高于對照組，差異有統計學意義（P<0.05）。 結論 在對慢性丙型肝炎患者使用聚乙二醇干擾素α-2a與利巴韋林治療過程中，加用自擬中藥方柴苓飲，能更有效地改善患者的肝臟硬度，減輕肝臟炎癥，改善肝臟功能，值得在臨床上進行推廣。

[關鍵詞] 中藥藥方;聯合治療;干擾素;利巴韋林;慢性丙型肝炎

[中圖分類號] R512.63? ? ? ? ? [文獻標識碼] A? ? ? ? ? [文章編號] 1673-9701（2019）15-0017-03

Clinical study on self-made Chailing decoction combined with interferon and ribavirin in the treatment of chronic hepatitis C

WU Yifeng

Department of Infectious Diseases， Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine， Foshan? ?528200， China

[Abstract] Objective To investigate the clinical efficacy of self-made traditional Chinese medicine Chailing decoction combined with interferon and ribavirin in the treatment of chronic hepatitis C. Methods A total of 26 patients who underwent chronic hepatitis C treatment in our hospital from January 2014 to May 2018 were randomly divided into study group and control group. Patients in the control group received peginterferon α-2a and ribavirin treatment， the study group also used the self-made Chinese medicine Chailing decoction treatment. And the two groups of patients were followed up for 6 months. Effectiveness of improving liver stiffness， and the improvement of serum alanine aminotransferase （ALT）， aspartate aminotransferase （AST）， alkaline phosphatase （ALP）， gamma-glutamyltransferase （GGT） indicators， albumin （ALB）， globulin （GLB） and albumin/globulin （A/G） in two groups of patients were compared. Results The effective rate of improvement of liver stiffness in the study group was higher than that in the control group（P<0.05）. The serum levels of ALT， AST， ALP and GGT in the study group were lower than those in the control group， and the difference was statistically significant（P<0.05）. The improvement of ALB， GLB and A/G in the study group was higher than that in the control group， and the difference was statistically significant（P<0.05）. Conclusion In the treatment of chronic hepatitis C patients with peginterferon α-2a and ribavirin， the use of self-made traditional Chinese medicine Chailing decoction can effectively improve the liver stiffness， reduce liver inflammation and improve liver function， which is worthy of clinical promotion.