朱培 李艷 張玉英


【摘要】 目的 探討乳腺癌患者運用保乳術聯合前哨淋巴結活檢術的臨床效果及對應激指標的影響。方法 60例乳腺癌患者為研究對象, 根據數字隨機表法將其分為對照組與觀察組, 每組30例。
對照組行改良乳腺癌根治術治療, 觀察組則運用保乳術聯合前哨淋巴結活檢術治療。比較兩組治療效果。結果 觀察組的拔管時間(5.23±0.91)d和手術時間(68.12±7.09)min均短于對照組的(10.46±6.46)d、(90.23±9.11)min, 術中出血量(84.33±9.67)ml和術后引流量(126.23±5.11)ml均少于對照組的(202.78±22.34)、(300.23±3.87)ml, 差異均有統計學意義(P<0.05)。術后, 觀察組的腫瘤壞死因子-α(TNF-α)和降鈣素原(PCT)水平分別為(2.73±0.28)、(4.11±0.38)ng/ml, 均低于對照組的(3.64±0.39)、(6.52±0.67)ng/ml, 差異有統計學意義(P<0.05)。觀察組的術后并發癥發生率為3.33%, 明顯低于對照組的23.33%, 差異有統計學意義(P<0.05)。觀察組的認知功能、社會功能、情緒功能、軀體功能、整體健康評分分別為(85.5±11.7)、(86.4±19.3)、(82.4±19.5)、(83.5±11.3)、(89.2±16.6)分, 均高于對照組的(76.5±12.9)、(75.5±19.2)、(70.9±22.1)、(71.6±17.4)、(76.5±11.7)分, 差異有統計學意義(P<0.05)。結論 臨床上運用保乳術聯合前哨淋巴結活檢術對乳腺癌患者進行治療效果顯著。
【關鍵詞】 乳腺癌;保乳術;前哨淋巴結活檢;改良乳腺癌根治術
DOI:10.14163/j.cnki.11-5547/r.2020.07.008
Effect analysis of clinical efficacy and stress index of breast conserving surgery combined with sentinel lymph node biopsy on breast cancer ? ZHU Pei, LI Yan, ZHANG Yu-ying, et al. Department of Breast and Thyroid Surgery, Heze Municipal Hospital, Heze 274000, China
【Abstract】 Objective ? To discuss the clinical effect of breast cancer patients treated with breast conserving surgery combined with sentinel lymph node biopsy and its influence on stress index. Methods ? A total of 60 breast cancer patients as study subjects were divided into control group and observation group by random number table method, with 30 cases in each group. The control group was treated by modified radical mastectomy for breast cancer, and the observation group was treated by breast conserving surgery combined with sentinel lymph node biopsy. The therapeutic effect in the two groups was compared. Results ? The extubation time (5.23±0.91) d and operation time (68.12±7.09) min in the observation group were shorter than (10.46±6.46) d
and (90.23±9.11) min in the control group, and amount of intraoperative hemorrhage (84.33±9.67) ml and amount of postoperative drainage (126.23±5.11) ml were less than (202.78±22.34) and (300.23±3.87) ml in the control group. Their difference was statistically significant (P<0.05). After operation, the tumor necrosis factor-α (TNF-α) and procalcitonin (PCT) were (2.73±0.28) and (4.11±0.38) ng/ml in the observation group, which were lower than (3.64±0.39) and (6.52±0.67) ng/ml in the control group, and their difference was statistically significant (P<0.05). The incidence of postoperative complications was 3.33% in the observation group, which was obviously lower than 23.33% in the control group, and the difference was statistically significant (P<0.05). The cognitive function, social function, emotional function, physical function and overall health score were (85.5±11.7), (86.4±19.3), (82.4±19.5), (83.5±11.3) and (89.2±16.6) points in the observation group, which were higher than (76.5±12.9), (75.5±19.2), (70.9±22.1), (71.6±17.4) and (76.5±11.7) points in the control group, and their difference was statistically significant (P<0.05). Conclusion ? Breast conserving surgery combined with sentinel lymph node biopsy shows remarkable effect for the treatment of patients with breast cancer.
【Key words】 Breast cancer; Breast conserving surgery; Sentinel lymph node biopsy; Modified radical mastectomy for breast cancer
乳腺癌是比較常見的一種惡性腫瘤, 通常可以分為兩種類型, 包括浸潤癌和非浸潤癌, 在臨床上表現為乳暈、乳頭異常、乳頭溢液以及乳腺腫塊等, 并且一些患者還會出現腋窩淋巴結轉移, 嚴重危害患者
健康[1, 2]。當前在治療乳腺癌時手術是常用方法之一, 但是不同術式的療效也存在著一定的區別。因此, 本文對保乳術聯合前哨淋巴結活檢術治療乳腺癌的臨床療效進行了分析, 詳情報告如下。
1 資料與方法
1. 1 一般資料 選擇本院2017年1月~2019年1月收治的60例乳腺癌患者為研究對象, 根據數字隨機表法將其分為對照組與觀察組, 每組30例。對照組年齡39~55歲, 平均年齡(45.6±9.1)歲;美國癌癥研究聯合會(AJCC)分期:Ⅱ期9例、Ⅰ期21例;其中10例為小葉癌、20例為導管癌。觀察組年齡40~58歲, 平均年齡(45.8±9.3)歲。AJCC分期:Ⅱ期8例、Ⅰ期
22例。其中9例為小葉癌、21例為導管癌。兩組患者年齡、病理類型、分期等一般資料比較差異無統計學意義(P>0.05), 具有可比性。納……