糖尿病男性血清生殖激素與精液質(zhì)量的臨床研究

[摘要] 目的 通過研究糖尿病男性血清生殖激素及其與精液質(zhì)量關(guān)系，為糖尿病男性的診治提供依據(jù)。方法 選取2018年1月—2019年1月在該院就診的男性糖尿病患者50例為對(duì)照組，同時(shí)選取該院就診的男性不育并糖尿病患者50例為觀察組。對(duì)比兩組患者的精子密度、精子總量、精液量、前向運(yùn)動(dòng)精比例（PR%）及兩組患者的血清生殖激素。結(jié)果 兩組患者精液質(zhì)量的檢測(cè)結(jié)果比較：精液量?jī)山M患者差異無統(tǒng)計(jì)學(xué)意義（P>0.05），而精子濃度、精子數(shù)量、PR（%）觀察組明顯低于對(duì)照組（P<0.05），觀察組FSH、LH水平明顯高于對(duì)照組，觀察組T水平明顯低于對(duì)照組（P<0.05），E2、PRL水平兩組差異無統(tǒng)計(jì)學(xué)意義（P>0.05）。結(jié)論 糖尿病患者造成生殖內(nèi)分泌紊亂，導(dǎo)致精液質(zhì)量下降，是不育的主要原因。

[關(guān)鍵詞] 糖尿病;血清生殖激素;精液質(zhì)量

[中圖分類號(hào)] R587.2? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] A? ? ? ? ? [文章編號(hào)] 1672-4062（2020）03（a）-0023-03

Clinical Study on Serum Reproductive Hormones and Semen Quality in Diabetic Men

LI Wen-mei

The Surabaya District of Jining First People's Hospital， Jining， Shandong Province， 273200 China

[Abstract] Objective To study the relationship between serum reproductive hormones and semen quality in diabetic men and to provide evidence for the diagnosis and treatment of diabetic men. Methods A total of 50 male diabetic patients from our hospital from January 2018 to January 2019 were selected as the control group， and 50 male infertile and diabetic patients from our hospital were selected as the observation group. Sperm density， total sperm， semen volume， forward motion sperm ratio （PR%） and serum reproductive hormones were compared between the two groups of patients. Results The semen quality test results of the two groups were compared： there was no significant difference in semen volume between the two groups（P>0.05）， while the sperm concentration， sperm number， and PR （%） in the observation group were significantly lower than those in the control group（P<0.05） The levels of FSH and LH in the observation group were significantly higher than those in the control group， the T levels in the observation group were significantly lower than those in the control group（P<0.05）， and the E2 and PRL levels were not different between the two groups （P>0.05）. Conclusion Diabetic patients cause reproductive and endocrine disorders， leading to a decline in semen quality， which is the main cause of infertility.

[Key words] Diabetes; Serum reproductive hormones; Semen quality

糖尿病為胰島素分泌缺陷或/和作用缺陷引起的血糖增高的一組代謝性疾病[1]。近年來，糖尿病的發(fā)病率越來越高，糖尿病已成為嚴(yán)重危害人類健康的世界公共衛(wèi)生問題，目前我國糖尿病的患者大于3000萬，而且糖尿病的發(fā)病越來越年輕化[2]。隨著二胎政策的放開，男性的生育年齡逐漸增大，因此有生育需求的男性患有糖尿病的比例越來越高。糖尿病嚴(yán)重影響男性的生殖健康，有報(bào)道50%以上的男性糖尿病患者表現(xiàn)出不同程度的不育[3]。該文選取2018年1月—2019年1月在該院就診的男性糖尿病患者100例，通過研究糖尿病男性血清生殖激素及其與精液質(zhì)量的關(guān)系，為糖尿病男性的診治提供依據(jù)。

1? 資料與方法

1.1? 一般資料

選取該院生殖中心就診的男性糖尿病患者50例為對(duì)照組，同時(shí)選取生殖中心就診的男性不育并糖尿病患者50例為觀察組。兩組……