來曲唑結合地塞米松對多囊卵巢綜合征患者血清MCP-1、AMH水平及妊娠率的影響

金雁　肖新益

【摘要】 目的：探討來曲唑結合地塞米松對多囊卵巢綜合征（PCOS）患者血清單核細胞趨化蛋白（MCP-1）、抗苗勒管激素（AMH）水平及妊娠率的影響。方法：選擇2015年12月-2018年5月在筆者所在醫院就診的PCOS患者86例，根據盲抽法將其分為兩組，各43例。對照組采用來曲唑治療，在此基礎上，觀察組采用地塞米松片治療，對比兩組雌激素水平、妊娠情況、血清MCP-1、AMH水平。結果：治療后兩組黃體生成激素、睪酮均低于治療前，且觀察組均低于對照組，差異均有統計學意義（P<0.05）;觀察組妊娠率（48.84%）高于對照組（23.26%），差異有統計學意義（P<0.05）;治療后兩組MCP-1、AMH水平均低于治療前，且觀察組均低于對照組，差異均有統計學意義（P<0.05）。結論：來曲唑結合地塞米松可有效降低PCOS患者雌激素水平，調節血清MCP-1、AMH水平，提高妊娠率。

【關鍵詞】 多囊卵巢綜合征 地塞米松 來曲唑 單核細胞趨化蛋白-1 抗苗勒管激素 妊娠率

doi：10.14033/j.cnki.cfmr.2020.15.056 文獻標識碼 B 文章編號 1674-6805（2020）15-0-02

The Effect of Letrozole Combined with Dexamethasone on Serum MCP-1 and AMH in Patients with Polycystic Ovary Syndrome and Pregnancy Rate/JIN Yan， XIAO Xinyi. //Chinese and Foreign Medical Research， 2020， 18（15）： -135

[Abstract] Objective： To investigate the effect of Letrozole combined with Dexamethasone on serum monocyte chemoattractant protein （MCP-1）， anti Mullerian hormone （AMH） and pregnancy rate in patients with polycystic ovary syndrome （PCOS）. Method： A total of 86 patients with PCOS who were treated in our hospital from December 2015 to May 2018 were selected and divided into two groups according to blind sampling method， 43 in each group. The control group was treated with Letrozole， on this basis， the observation group was treated with Dexamethasone Tablets， and the estrogen level， pregnancy situation， serum MCP-1， AMH level of the two groups were compared. Result： After treatment， the luteinizing hormone and testosterone in the two groups were lower than those before treatment， and the observation group was lower than the the control group， the differences were statistically significant （P<0.05）. The pregnancy rate in the observation group （48.84%） was higher than that in the control group （23.26%）， the difference was statistically significant （P<0.05）. The levels of MCP-1 and AMH in the two groups after treatment were lower than those before treatment， and the observation group were lower than the control group， the differences were statistically significant （P<0.05）. Conclusion： Letrozole combined with Dexamethasone can effectively reduce the estrogen level of PCOS patients， regulate the serum MCP-1 and AMH levels， and improve the pregnancy rate.

[Key words] Polycystic ovary syndrome Dexamethasone Letrozole Monocyte chemoattractant protein-1 Against Mullerian hormone Pregnancy rate

First-authors address： Huangshi Aikang Hospital， Huangshi 435000， China

多囊卵巢綜合征（PCOS）是常見的女性內分泌代謝異常疾病之一，以慢性無排卵和高雄激素血癥為特征，主要臨床表現為月經周期不規律、不孕等[1-2]。現在對于多囊卵巢綜合征，手術治療已經不是第一線治療方法，多數通過藥物治療，都順利懷孕，是很多患者治療的目的[3]。來曲唑是一個芳香化酶抑制劑，芳香化酶可催化女性身體內雄激素，從而抑制身體里面雄激素轉化為雌激素。有研究發現，聯合地塞米松使用可更有效地促進排卵，提高妊娠率[4]。鑒于此，本研究主要探討來曲唑結合地塞米松對PCOS患者血清單核細胞趨化蛋白（MCP-1）、抗苗勒管激素（AMH）水平及妊娠率的影響，現報道如下。