《中藥成方制劑》中治療胃炎方劑的用藥分析

謝玉玲　劉玉鳳　溫建英 李丹　徐偉

【摘要】 目的：分析《中藥成方制劑》中治療胃炎方劑的用藥規律。方法：提取《中藥成方制劑》中治療胃炎的方劑，利用中醫傳承輔助平臺（V2.5）中的方劑分析模塊研究治療胃炎方劑中的藥物使用頻次、五味、歸經、常用藥對及新方組合。結果：90首治療胃炎的方劑中，用于胃炎的藥物共206味，五味以苦、甘、辛為主，歸經以脾經、肝經、胃經、肺經、心經為主;當支持度為8（8.9%）時，常用藥對有13個;當置信度為0.8時，藥物組合有4個;聚類出新方組合5個。結論：治療胃炎的方劑中以理氣健脾、收斂止血、行氣止痛藥物為主，通過合理配伍以發揮治療作用。

【關鍵詞】 中藥成方制劑 胃炎 數據挖掘 用藥規律

doi：10.14033/j.cnki.cfmr.2020.16.066 文獻標識碼 B 文章編號 1674-6805（2020）16-0-04

Analysis of the Prescriptions for Treating Gastritis in the National Standard for Chinese Patent Drugs/XIE Yuling， LIU Yufeng， WEN Jianying， LI Dan， XU Wei. //Chinese and Foreign Medical Research， 2020， 18（16）： -164

[Abstract] Objective： To analyze the medication law of the prescriptions for treating gastritis in the National Standard for Chinese Patent Drugs. Method： Extracting the prescriptions for treating gastritis in the National Standard for Chinese Patent Drugs， and use the formula analysis module in the traditional Chinese medicine inheritance auxiliary platform （V2.5） to study the frequency， five flavor， meridian tropism， common drug pairs and new formula combinations of the medicines of the prescriptions for treating gastritis. Result： Among the 90 prescriptions for treating gastritis， 206 medicines were used for gastritis. In the distribution of five flavor of traditional Chinese medicine， bitter flavor， sweet flavor and pungent flavor were mainly used， and in the meridian tropism， spleen meridian， liver meridian， lung meridian， stomach meridians and heart meridian were mainly used. When the support degree was 8 （8.9%）， there were 13 pairs of common medicines. When the confidence degree was 0.8， there were 4 combinations， and clustering out 5 combinations of new prescriptions. Conclusion： The prescriptions for treating gastritis are mainly for regulating qi and invigorating spleen， astringency and hemostasis and moving qi to relieve pain drugs， through reasonable compatibility to play a therapeutic role.

[Key words] National Standard for Chinese Patent Drugs Gastritis Data mining Medication law

First-authors address： Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine， Fuzhou 350001， China

胃炎是由多種因素導致的胃黏膜炎癥反應，是常見的消化系統疾病之一[1]。胃炎可引起多種并發癥，病情嚴重者可轉為胃癌，給患者帶來沉重的心理負擔和經濟負擔[2-3]。中醫提倡標本兼治，特別是在慢性萎縮性胃炎治療中。《中華人民共和國衛生部藥品標準-中藥成方制劑》（以下簡稱為《中藥成方制劑》）共有20冊，記載了4 052首方劑，是中醫藥中的寶貴資源。通過挖掘《中藥成方制劑》中治療胃炎方劑的用藥規律，有利于對中醫藥進行傳承、創新，也能為臨床診療提供參考。數據挖掘技術能夠幫助研究者從眾多的數據中提取出潛藏的有用信息，為從龐大的方劑中發現潛在的用藥規律提供技術支持。目前，很多學者將數據挖掘技術應用于中醫藥的用藥規律研究中[4-7]。……