丁苯酞治療急性進展性穿支動脈病變型腦梗死患者的臨床效果及對日常生活能力量表評分的影響

劉潤妮

[摘要] 目的 探討對急性進展性穿支動脈病變型腦梗死患者實施丁苯酞治療的效果。 方法 選擇2018年4月～2019年8月我院治療的64例急性進展性穿支動脈病變型腦梗死患者，隨機分為對照組（32例，應用常規治療）和觀察組（32例，應用常規治療+丁苯酞治療）。比較兩組治療總有效率、C反應蛋白（CRP）水平、血清同型半胱氨酸（Hcy）水平、日常生活能力量表評分及神經功能缺損評分。 結果 觀察組治療總有效率（87.50%）高于對照組（65.63%）（P<0.05）;觀察組患者治療后CRP、Hcy水平較對照組更低（P<0.05）;觀察組患者治療第7天、第14天日常生活能力量表評分較對照組更高（P<0.05）;觀察組患者治療第7天、第14天神經功能缺損評分較對照組更低（P<0.05）。 結論 對急性進展性穿支動脈病變型腦梗死患者實施丁苯酞治療有助于增強療效、減輕炎癥反應，對增強患者日常生活能力及恢復神經功能具有良好的促進作用。

[關鍵詞] 急性;進展性;穿支動脈病變型腦梗死;丁苯酞;日常生活能力

[中圖分類號] R743.3 ? ? ? ? ?[文獻標識碼] B ? ? ? ? ?[文章編號] 1673-9701（2020）24-0039-03

[Abstract] Objective To explore the effect of butylphthalide therapy on patients with acute progressive perforating artery lesion with cerebral infarction. Methods A total of 64 patients with acute progressive perforating artery lesion with cerebral infarction who were treated in our hospital from April 2018 to August 2019 were randomly selected and divided into the control group， in which 32 patients were treated with conventional therapy， and the observation group， in which 32 patients were treated with conventional therapy and butylphthalide. Total effective rates， C-reactive protein（CRP） levels， serum homocysteine（Hcy） levels， activities of daily living scale scores and neurological impairment scores were compared between the two groups. Results The total effective rate in the observation group（87.50%） was higher than that in the control group（65.63%）（P<0.05）. The levels of CRP and Hcy in the observation group after treatment were lower than those in the control group（P<0.05）. Activities of daily living scale scores in the observation group on the 7th and 14th day of treatment were higher than those in the control group（P<0.05）. Neurological impairment scores in the observation group on the 7th and 14th day of treatment were lower than those in the control group（P<0.05）. Conclusion Butylphthalide therapy for patients with acute progressive perforating artery lesion with cerebral infarction can enhance the curative effect， reduce inflammation， and promote the abilities of daily living and recoveries of neurological function.

[Key words] Acute; Progressive; Perforating artery lesion with cerebral infarction; Butylphthalide; Activities of daily living

穿支動脈病變型腦梗死主要是指穿支動脈口出現粥樣硬化或因小動脈出現纖維玻璃樣變，從而導致急性穿支動脈區出現孤立性梗死[1]，有數據顯示[2-3]，在腦梗死患病人群中，大約有30%患者為穿支動脈病變型腦梗死，患者早期可出現嚴重運動功能障礙，從而使其日常生活能力嚴重下降。有研究認為[4-6]，出現運動功能障礙主要是由于穿支動脈為終末動脈，側支循環較差，而動脈入口處出現粥樣硬化，更易加重病情，故臨床治療上述疾病以加強抗栓治療、改善血液灌注及改善預后為原則，其中藥物療法是治療上述疾病的常用療法。為探討丁苯酞治療該病的可行性及有效性，我院對急性進展性穿支動脈病變型腦梗死患者實施丁苯酞治療，現報道如下。

1 資料與方法

1.1 一般資料

選擇2018年4月～2019年8月我院治療的64例急性進展性穿支動脈病變型腦梗死患者，隨機分為對照組32例和觀察組32例。……